An application of statistics in mixture of exponential distributions

Order statistics in application to exponential distribution

Berardinelli-Seip Syndrome

We have reported two cases of Berardinelli-syndrome in a family which is a rare autosomal recessive disorder of the adipose tissue, originally described by Berardinelli and Seip, has been reported in approximately 120 patients of various ethnic origins. Assuming that only 1 in 4 patients is reported.Patients present with acanthosis nigricans (dark velvety pigmentation of the skin) in the axilla, neck or groin, severe insulin resistance, high levels of serum insulin and serum triglycerides.The other clinical features consist of enlarged hands, feet and prominent mandible (acromegaloid features), increased sweating, umbilical hernia and lytic lesions (bone appear to be eaten-up on X-rays) in long bones of the upper and lower extremities (arms, forearm, hands, thigh, calf, legs and feet) such as humerus, femur, etc. Hepatomegaly from fatty liver is almost universal and may ultimately lead to cirrhosis. Splenomegaly is common. Nearly all patients have a prominent umbilicus or frank umbilical hernia. Females present with enlarged clitoris, increased body hair, absence of or irregular menstrual cycles, and polycystic ovaries (enlarged ovaries). Only a few affected women have had successful pregnancies, whereas affected men have normal fertilit

An application of the multivariate extended Poisson distribution in 2 times 2 contingency tables Final report

Application of multivariate extended Poisson distribution

Exclusive transabdominal trans-amniotic approach for chorionic villus sampling in posterior placenta: a novel approach for prenatal diagnosis of genetic disorders

Background: The objective of the study was to evaluate role and safety of transabdominal trans-amniotic approach for Chorionic villus sampling (CVS) for prenatal diagnosis of genetic disorders.Methods: Retrospective analytical study carried out on data form couples coming for pre-natal diagnosis from January 2010 to February 2021. Patient related parameters like age, gestational age; procedure related parameters like amount of sample, number of attempts required; different genetic disorder diagnosed and complications by both the approaches of CVS were recorded and analyzed.Results: Total 2287 patients undergoing CVS with mean age of 27±3.3 years were included. Majority (1621;70.9%) had CVS procedure at gestational age of 12-14 weeks. On analyzing physician’s perception, 663 (29%) patients having complete posterior placenta could not be accessible with routine trans-abdominal CVS and opted for trans-amniotic approach. Amount of sample yield and number of attempts were not statistically significant (p>0.05) by both methods of CVS. Thalassemia major was found in 948 (41.45%) followed by thalassemia minor in 525 (22.96%) patients. No statistically significant difference was found for developing complications by both the methods (p>0.05). Most common complication was pain and discomfort which was relieved by simple analgesics. Out of total 17 (0.74%) abortions; 13 (0.80%) from routine transabdominal and 4 (0.60%) from trans-amniotic route CVS with no statistically significant difference among them (p>0.05). No case of post procedure infection was observed.Conclusions: In complete posterior placenta CVS procedures usually postponed by most physicians leading to delay in diagnosis of genetic disorders. The novel method transabdominal trans-amniotic approach for CVS is effective and safe in skilled hands and can help in early prenatal diagnosis of genetic disorders.

Profitability of organic and conventional dairy production with different dietary proportions of high-quality grass silage

Profitability in milk production was calculated using diets with three different proportions of high-quality grass silage. The treatments consisted of the same feeds, but differed in the dietary proportion of forage: low (L), medium (M) and high (H), representing one conventional and two organic diets. The calculations were based on results in feed intake and milk production from a large dairy cow experiment. In the calculations, three different districts with different conditions for farming were used as models, and calculations were performed on two different herd sizes. In addition, current financial supports were both included and excluded in the calculations. The results showed only minor differences in profitability between using in average 60% or 70% of dry matter (DM) of silage in diets used in organic production. In conventional production, it was profitable to increase the average dietary proportion of silage from 50% to 60% of DM when the prices of concentrate and grains were as high as at the present. The results showed clear economic benefits of increasing the proportion of high-quality silage in conventional Scandinavian dairy cow diets up to levels similar to the standards of the organic production system

Quantum Backflow States from Eigenstates of the Regularized Current Operator

We present an exhaustive class of states with quantum backflow -- the phenomenon in which a state consisting entirely of positive momenta may have negative current and the probability flows in the opposite direction to the momentum. They are characterized by a general function of momenta subject to very weak conditions. Such a family of states is of interest in the light of a recent experimental proposal to measure backflow. We find one particularly simple state which has surprisingly large backflow -- about 41 percent of the lower bound on flux derived by Bracken and Melloy. We study the eigenstates of a regularized current operator and we show how some of these states, in a certain limit, lead to our class of backflow states. This limit also clarifies the correspondence between the spectrum of the regularized current operator, which has just two non-zero eigenvalues in our chosen regularization, and the usual current operator.Comment: 16 pages, 2 figure

Cardiovascular Benefits of Forgiveness in Women: A Psychophysiological Study

2012 Denman Undergraduate Research Forum Winner: 3rd PlaceThe perseverative cognition hypothesis posits that psychological stress (e.g., sustained mental representations of past events) contributes to somatic disease through prolonged activation of cardiovascular and other biomechanisms. In the current study, we examined the effects of forgiveness compared to unforgiveness states, the latter conceptualized as a form of perseveration, on cardiovascular function. Ruminating about a hurtful event has been associated with higher heart rate, blood pressure, and muscle tension compared to forgiving. Specific aims of the current study are to examine the impact of forgiveness on vagal function—indexed by heart rate variability (HRV)—using an electrocardiogram. Healthy female participants’ (N = 60) HR data was continuously measured during a 5-minute baseline period, a 5-minute negative emotion induction, and 5 minutes of a randomized recovery manipulation. During the negative emotion induction, participants were instructed to think about a transgressor with whom they were feeling frustrated. Participants were then randomized into one of three recovery conditions: forgiveness (imagine forgiving the transgressor), extended frustration (continue thinking about the transgressor), and distraction (read neutral, thorough laundry instructions). After controlling for baseline and task HRV, participants in the forgiveness phase had higher HRV than those in both the extended frustration and distraction phases. Results suggest that: a) forgiveness may influence somatic health through mechanisms of cardiac autonomic control, b) lower HRV during unforgiveness is analogous to perseverative states such as worry and rumination, and c) among women, forgiveness of a transgressor may be a beneficial coping strategy. Overall, the findings support the perseverative cognition hypothesis, and suggest a link between forgiveness and cardiovascular health.College of Arts & Sciences Undergraduate Research ScholarshipNo embarg