The Caregivers’ Voice

to provide the caregivers’ perspective on being involved in design for well-being, Christine De lille spoke to care professionals at De Wever, an institution which specialises in care for elderly with dementia

Development and Internal Validation of a Multivariable Prediction Model for Adrenocortical-Carcinoma-Specific Mortality

Adrenocortical carcinoma (ACC) has an incidence of about 1.0 per million per year. In general, survival of patients with ACC is limited. Predicting survival outcome at time of diagnosis is a clinical challenge. The aim of this study was to develop and internally validate a clinical prediction model for ACC-specific mortality. Data for this retrospective cohort study were obtained from the nine centers of the Dutch Adrenal Network (DAN). Patients who presented with ACC between 1 January 2004 and 31 October 2013 were included. We used multivariable Cox proportional hazards regression to compute the coefficients for the prediction model. Backward stepwise elimination was performed to derive a more parsimonious model. The performance of the initial prediction model was quantified by measures of model fit, discriminative ability, and calibration. We undertook an internal validation step to counteract the possible overfitting of our model. A total of 160 patients were included in the cohort. The median survival time was 35 months, and interquartile range (IQR) 50.7 months. The multivariable modeling yielded a prediction model that included age, modified European Network for the Study of Adrenal Tumors (mENSAT) stage, and radical resection. The c-statistic was 0.77 (95% Confidence Interval: 0.72, 0.81), indicating good predictive performance. We developed a clinical prediction model for ACC-specific mortality. ACC mortality can be estimated using a relatively simple clinical prediction model with good discriminative ability and calibration

Quick-scan on different scenarios relating to the ACFM 2003 advice: biological and economic consequences

In dit rapport worden de resultaten beschreven van een quick-scan die in het najaar van 2003 is uitgevoerd door het Nederlands Instituut voor Visserijonderzoek en het Landbouw Economisch Instituut op verzoek van de Directie Visserij van het ministerie van Landbouw, Natuurbeheer en Voedselveiligheid. Naar aanleiding van de biologische adviezen van ICES in oktober 2003 ten aanzien van het beheer een aantal visbestanden in de Noordzee, heeft het ministerie een lijst van vragen en scenario’s geformuleerd waar zij aanvullende biologische en economische analyses van wilde om de consequenties van verschillende beleidsopties te kunnen wegen

Samenvatting en evaluatie van het onderzoeksprogramma Bestek 6c, Verbetering rekenmodel voor visquota

De doelstellingen van het tweejarig onderzoeksprogramma Bestek Ond/2002-1/6C/01 Verbetering rekenmodel voor visquota (maart 2002 – oktober 2004, verder bestek 6c genoemd) zijn enerzijds een evaluatie van de technische en politieke bruikbaarheid van het rekenmodel voor de bepaling van TAC’s in het Gemeenschappelijk Visserij Beleid, en anderzijds een exploratie naar de mogelijkheid om TAC’s voor meerdere soorten tegelijk vast te stellen

WORKSHOP ON GUIDELINES FOR MANAGEMENT STRATEGY EVALUATIONS (WKGMSE2)

The purpose of the meeting was to bring up to date the methodologies and technical specifications that should be incorporated in Management Strategy Evaluation (MSE) work in ICES. The workshop was tasked with reviewing recent methodological and practical MSE work conducted in ICES and around the world, as well as the guidelines provided by the 2013 ICES Workshop on Guidelines for Management Strategy Evaluations (WKGMSE). The Terms of Reference indicated that the revision should include all aspects involved in MSE, while paying specific attention to several issues that had been identified through ICES practice. The Terms of Reference also requested WKGMSE 2 to consider how best to disseminate the guidelines to experts within the ICES community and the need for training courses. The workshop addressed all its Terms of Reference. The main results of the workshop are the revised MSE guidelines, as well as recommendations in relation to the ICES criterion for defining a management strategy as precautionary and in relation to the evaluation and advice on rebuilding strategies.publishedVersio