Superembeddings, Non-Linear Supersymmetry and 5-branes

We examine general properties of superembeddings, i.e., embeddings of supermanifolds into supermanifolds. The connection between an embedding procedure and the method of non-linearly realised supersymmetry is clarified, and we demonstrate how the latter arises as a special case of the former. As an illustration, the super-5-brane in 7 dimensions, containing a self-dual 3-form world-volume field strength, is formulated in both languages, and provides an example of a model where the embedding condition does not suffice to put the theory on-shell.Comment: plain tex, 28 p

Duality Symmetry in the Schwarz-Sen Model

The continuous extension of the discrete duality symmetry of the Schwarz-Sen model is studied. The corresponding infinitesimal generator $Q$ turns out to be local, gauge invariant and metric independent. Furthermore, $Q$ commutes with all the conformal group generators. We also show that $Q$ is equivalent to the non---local duality transformation generator found in the Hamiltonian formulation of Maxwell theory. We next consider the Batalin--Fradkin-Vilkovisky formalism for the Maxwell theory and demonstrate that requiring a local duality transformation lead us to the Schwarz--Sen formulation. The partition functions are shown to be the same which implies the quantum equivalence of the two approaches.Comment: 10 pages, latex, small changes, final version to appear in Phys. Rev.

Duality in a fermion-like formulation for the electromagnetic field

We employ the Dirac-like equation for the gauge field proposed by Majorana to obtain an action that is symmetric under duality transformation. We also use the equivalence between duality and chiral symmetry in this fermion-like formulation to show how the Maxwell action can be seen as a mass term.Comment: 4 pages. Revtex. Final version to be published in Phys. Rev.

Human lactate dehydrogenase A undergoes allosteric transitions under pH conditions inducing the dissociation of the tetrameric enzyme

The aerobic energetic metabolism of eukaryotic cells relies on the glycolytic generation of pyruvate, which is subsequently channelled to the oxidative phosphorylation taking place in mitochondria. However, under conditions limiting oxidative phosphorylation, pyruvate is coupled to alternative energetic pathways, e.g. its reduction to lactate catalyzed by lactate dehydrogenases (LDHs). This biochemical process is known to induce a significant decrease in cytosolic pH, and is accordingly denoted lactic acidosis. Nevertheless, the mutual dependence of LDHs action and lactic acidosis is far from being fully understood. Using human LDH-A, here we show that when exposed to acidic pH this enzyme is subjected to homotropic allosteric transitions triggered by pyruvate. Conversely, human LDH-A features Michaelis–Menten kinetics at pH values equal to 7.0 or higher. Further, citrate, isocitrate, and malate were observed to activate human LDH-A, both at pH 5.0 and 6.5, with citrate and isocitrate being responsible for major effects. Dynamic light scattering (DLS) experiments revealed that the occurrence of allosteric kinetics in human LDH-A is mirrored by a consistent dissociation of the enzyme tetramer, suggesting that pyruvate promotes tetramer association under acidic conditions. Finally, using the human liver cancer cell line HepG2 we isolated cells featuring cytosolic pH equal to 7.3 or 6.5, and we observed a concomitant decrease in cytosolic pH and lactate secretion. Overall, our observations indicate the occurrence of a negative feedback between lactic acidosis and human LDH-A activity, and a complex regulation of this feedback by pyruvate and by some intermediates of the Krebs cycle

Poincare Invariance of a Quantized Duality Symmetric Theory

The noncovariant duality symmetric action put forward by Schwarz-Sen is quantized by means of the Dirac bracket quantization procedure. The resulting quantum theory is shown to be, nevertheless, relativistically invariant

The anomaly line bundle of the self-dual field theory

In this work, we determine explicitly the anomaly line bundle of the abelian self-dual field theory over the space of metrics modulo diffeomorphisms, including its torsion part. Inspired by the work of Belov and Moore, we propose a non-covariant action principle for a pair of Euclidean self-dual fields on a generic oriented Riemannian manifold. The corresponding path integral allows to study the global properties of the partition function over the space of metrics modulo diffeomorphisms. We show that the anomaly bundle for a pair of self-dual fields differs from the determinant bundle of the Dirac operator coupled to chiral spinors by a flat bundle that is not trivial if the underlying manifold has middle-degree cohomology, and whose holonomies are determined explicitly. We briefly sketch the relevance of this result for the computation of the global gravitational anomaly of the self-dual field theory, that will appear in another paper.Comment: 41 pages. v2: A few typos corrected. Version accepted for publication in CM

Superbrane Actions and Geometrical Approach

We review a generic structure of conventional (Nambu-Goto and Dirac-Born-Infeld-like) worldvolume actions for the superbranes and show how it is connected through a generalized action construction with a doubly supersymmetric geometrical approach to the description of super-p-brane dynamics as embedding world supersurfaces into target superspaces.Comment: Based on talks given by the authors at the Volkov Memorial Seminar "Supersymmetry and Quantum field Theory" (Kharkov, January 5-7, 1997), LaTeX file, 11 pages Misprints corrected, references adde

On possible generalization of the superstring action to eleven dimensions

We suggest a D=11 super Poincar\'e invariant action for the superstring which has free dynamics in the physical variables sector. Instead of the standard approach based on the searching for an action with local $\kappa$-symmetry (or, equivalently, with corresponding first class constraints), we propose a theory with fermionic constraints of second class only. Then the $\kappa$-symmetry and the well known $\Gamma$-matrix identities are not necessary for the construction. Thus, at the classical level, the superstring action of the type described can exist in any spacetime dimensions and the known brane-scan can be revisited.Comment: 23 pages, RevTex file, to be published in Phys. Rev.

Six-dimensional (1,0) effective action of F-theory via M-theory on Calabi-Yau threefolds

The six-dimensional effective action of F-theory compactified on a singular elliptically fibred Calabi-Yau threefold is determined by using an M-theory lift. The low-energy data are derived by comparing a circle reduction of a general six-dimensional (1,0) gauged supergravity theory with the effective action of M-theory on the resolved Calabi-Yau threefold. The derivation includes six-dimensional tensor multiplets for which the (anti-) self-duality constraints are imposed on the level of the five-dimensional action. The vector sector of the reduced theory is encoded by a non-standard potential due to the Green-Schwarz term in six dimensions. This Green-Schwarz term also contains higher curvature couplings which are considered to establish the full map between anomaly coefficients and geometry. F-/M-theory duality is exploited by moving to the five-dimensional Coulomb branch after circle reduction and integrating out massive vector multiplets and matter hypermultiplets. The associated fermions then generate additional Chern-Simons couplings at one-loop. Further couplings involving the graviphoton are induced by quantum corrections due to excited Kaluza-Klein modes. On the M-theory side integrating out massive fields corresponds to resolving the singularities of the Calabi-Yau threefold, and yields intriguing relations between six-dimensional anomalies and classical topology.Comment: 55 pages, v2: typos corrected, discussion of loop corrections improve

Symmetry transform in the Faddeev-Jackiw quantization of dual models

We study the presence of symmetry transformations in the Faddeev-Jackiw approach for constrained systems. Our analysis is based in the case of a particle submitted to a particular potential which depends on an arbitrary function. The method is implemented in a natural way and symmetry generators are identified. These symmetries permit us to obtain the absent elements of the sympletic matrix which complement the set of Dirac brackets of such a theory. The study developed here is applied in two different dual models. First, we discuss the case of a two-dimensional oscillator interacting with an electromagnetic potential described by a Chern-Simons term and second the Schwarz-Sen gauge theory, in order to obtain the complete set of non-null Dirac brackets and the correspondent Maxwell electromagnetic theory limit.Comment: 22 pages, RevTex file, no figur