Response to Wirostko et al. Re: "Cross-Linked Hyaluronic Acid as Tear Film Substitute" by Posarelli et al. (J Ocul Pharmacol Ther 2019;35(7):381-387)

Response to Wirostko et al. Re: “Cross-Linked Hyaluronic Acid as Tear Film Substitute” by Posarelli et al. (J Ocul Pharmacol Ther 2019;35(7):381–387)." Journal of Ocular Pharmacology and Therapeutics, 36(4), pp. 206–20

What is the impact of intraoperative microscope-integrated oct in ophthalmic surgery? Relevant applications and outcomes. a systematic review

Background: Optical coherence tomography (OCT) has recently been introduced in the operating theatre. The aim of this review is to present the actual role of microscope-integrated optical coherence tomography (MI-OCT) in ophthalmology. Method: A total of 314 studies were identified, following a literature search adhering to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. After full-text evaluation, 81 studies discussing MI-OCT applications in ophthalmology were included. Results: At present, three microscope-integrated optical coherence tomography systems are commercially available. MI-OCT can help anterior and posterior segment surgeons in the decision-making process, providing direct visualization of anatomic planes before and after surgical manoeuvres, assisting in complex cases, and detecting or confirming intraoperative complications. Applications range from corneal transplant to macular surgery, including cataract surgery, glaucoma surgery, paediatric examination, proliferative diabetic retinopathy surgery, and retinal detachment surgery. Conclusion: The use of MI-OCT in ophthalmic surgery is becoming increasingly prevalent and has been applied in almost all procedures. However, there are still limitations to be overcome and the technology involved remains difficult to access and use

BOLD Vision 2020:Designing a vision for the future of Big Open Legal Data

The vision of openlaws.eu is to make access to justice easier for citizens, business- es and legal experts. For this purpose, an innovative legal information platform has been designed by the openlaws.eu project, considering the needs of various stakeholder groups as well as the latest developments in technology and our information society. Access to justice is a fundamental problem in the European Union. There are over 500 million citizens and over 21 million businesses who live, work and operate in 28 jurisdictions, written in 24 official languages. A common market cannot work without a legal system as a basis. Legal information is a public good and it is the duty of governments and the EU to inform citizens and business about the law. In a democracy and under the rule of law everybody should know legislation and case law – or at least have access to it. Legal tech is a new terms for new technology that can be applied to legal information in order to create better access and better understanding of the law. However, just because things can be done, does not mean automatically that they are done. Financial and organisational restrictions and the lack of competency can be a deal-breaker for innovation. Open data, open innovation and open source software can be a potential solution to this problem, especially when combined to one coherent ecosystem. openlaws.eu has developed a prototype platform upon these new open concepts. The application and implementation of some of the features of this innovative legal cloud service indicate where the road of “Big Open Legal Data” can lead us in the upcoming years. The project team envisages an environment, where a “social layer” is put on top of the existing “institutional layer”. Citizens, businesses and legal experts can actively collaborate on the basis of primary legislation and case law. Linked and aggregated legal data provide a solid basis. Such information can then be represented in traditional and more innovative ways. Text and data mining as well as legal intelligence help to process large amounts of legal information automatically, so that experts can focus on the more complicated questions. In the next five years more and more legal data will be opened up, not only because of the PSI Directive, but also because it is in the best interest of governments. As a result, we anticipate that more legal tech start-ups will emerge, as already happened during the past two years. They will apply innovative concepts and new technology on existing legal information and create better access to justice in the EU, in Member States and in the world

Diet Prevents Social Stress-Induced Maladaptive Neurobehavioural and Gut Microbiota Changes in a Histamine-Dependent Manner

Exposure to repeated social stress may cause maladaptive emotional reactions that can be reduced by healthy nutritional supplementation. Histaminergic neurotransmission has a central role in orchestrating specific behavioural responses depending on the homeostatic state of a subject, but it remains to be established if it participates in the protective effects against the insults of chronic stress afforded by a healthy diet. By using C57BL/6J male mice that do not synthesize histamine (Hdc(−/−)) and their wild type (Hdc(+/+)) congeners we evaluated if the histaminergic system participates in the protective action of a diet enriched with polyunsaturated fatty acids and vitamin A on the deleterious effect of chronic stress. Behavioural tests across domains relevant to cognition and anxiety were performed. Hippocampal synaptic plasticity, cytokine expression, hippocampal fatty acids, oxylipins and microbiota composition were also assessed. Chronic stress induced social avoidance, poor recognition memory, affected hippocampal long-term potentiation, changed the microbiota profile, brain cytokines, fatty acid and oxylipins composition of both Hdc(−/−) and Hdc(+/+) mice. Dietary enrichment counteracted stress-induced deficits only in Hdc(+/+) mice as histamine deficiency prevented almost all the diet-related beneficial effects. Interpretation: Our results reveal a previously unexplored and novel role for brain histamine as a mediator of many favorable effects of the enriched diet. These data present long-reaching perspectives in the field of nutritional neuropsychopharmacology

Geographic information retrieval in a mobile environment: evaluating the needs of mobile individuals

This paper describes research that aims to define the information needs of mobile individuals, to implement a mobile information system that can satisfy those needs, and finally to evaluate the performance of that system with end-users. First a review of the emerging discipline of geographic information retrieval (GIR) is presented as background to the more specific issue of mobile information retrieval. Following this, a user needs study is described evaluating the requirements of potential users of a mobile information system; the study finds that there is a strong geographic component to users' information needs. Next, four geographic post-query filters are described which attempt to represent the region of space associated with an individual's query made at some specific spatial location. These filters are spatial proximity (distance in space), temporal proximity (travel time), speed-heading prediction surfaces (likelihood of visiting locations) and visibility (locations that can be seen). Two of these filters — spatial proximity and speed-heading prediction surfaces — are implemented in a mobile information system and subsequently evaluated with users in an outdoor setting. The results of evaluation suggest that retrieved information to which post-query geographic filters have been applied is considered more relevant than unfiltered information, and that users find information sorted by spatial proximity to be more relevant than that sorted by a prediction surface of likely future locations. The paper closes with a discussion of the wider implications of these results for developers of mobile information systems and location-based services