Gamma Knife radiosurgery in skull base meningiomas: a possible relationship between somatostatin receptor decrease and early neurological improvement without tumor shrinkage at short-term imaging follow-up

BACKGROUND: This study investigates a possible relationship between the effects of gamma knife (GK) on meningioma somatostatin receptors (SRs) and the high rate of early neurological improvement without tumour reduction at short-term imaging follow-up. METHODS: From December 1997 to December 2002, somatostatin receptor scintigraphy (SRS) using an 111Indium-labelled somatostatin analogue, Octreotide, was performed both before and 7-12 months after radiosurgery in 20 patients with intracranial meningiomas. Semiquantitative data were calculated as an SRS index. FINDINGS: The pre-GK SRS index was always > 1, averaging 4.44 +/- 3.20. There were no statistically significant differences between the pre-GK average values of primary (4.80 +/- 3.65) and residual (3.75 +/- 1.93) meningiomas. At the first clinical/MRI follow-up, the neurological examination had improved in 15/20 (75%) and had not changed in 5/20 patients. A corresponding slight tumour shrinkage on high-resolution MRI was documented in 3/20 cases only. The post-GK average SRS index was lower than pre-GK values both in primary (3.87 +/- 3.19) and in adjuvant (2.52 +/- 1.14) treatments, but the differences were not significant. However, the subgroup of patients with early neurological improvement showed a higher pre-GK average SRS index (5.21 +/- 3.33) and a more substantial post-GK average SRS index decrease (3.86 +/- 3.00) than the patients whose clinical condition remained stable (2.10 +/- 0.59 and 1.99 +/- 0.55, respectively). The difference between the two subgroups of patients proved to be statistically significant (P < 0.05). CONCLUSIONS: Our preliminary findings suggest a possible relationship between a decrease in the concentration of SRs on meningioma cells at short-term functional imaging follow-up after radiosurgery and early neurological improvement

The dichotomous role of inflammation in the CNS: A mitochondrial point of view

Innate immune response is one of our primary defenses against pathogens infection, although, if dysregulated, it represents the leading cause of chronic tissue inflammation. This dualism is even more present in the central nervous system, where neuroinflammation is both important for the activation of reparatory mechanisms and, at the same time, leads to the release of detrimental factors that induce neurons loss. Key players in modulating the neuroinflammatory response are mitochondria. Indeed, they are responsible for a variety of cell mechanisms that control tissue homeostasis, such as autophagy, apoptosis, energy production, and also inflammation. Accordingly, it is widely recognized that mitochondria exert a pivotal role in the development of neurodegenerative diseases, such as multiple sclerosis, Parkinson’s and Alzheimer’s diseases, as well as in acute brain damage, such in ischemic stroke and epileptic seizures. In this review, we will describe the role of mitochondria molecular signaling in regulating neuroinflammation in central nervous system (CNS) diseases, by focusing on pattern recognition receptors (PRRs) signaling, reactive oxygen species (ROS) production, and mitophagy, giving a hint on the possible therapeutic approaches targeting mitochondrial pathways involved in inflammation

[123I]FP-CIT SPET imaging in drug-induced Parkinsonism

We assessed the status of dopamine nerve terminals in patients treated with dopamine receptor blocking agents (DRBAs) who had developed drug-induced parkinsonism (DIP). We performed [(123)I]FP-CIT SPET in 32 consecutive patients who were on DRBAs for at least 6 months and developed extrapyramidal signs. The UPDRS-III was used to assess clinical severity. Twenty-six age- and sex-matched healthy subjects served as control group. Putamen [(123)I]FP-CIT SPET binding was reduced in 14 and normal in the remaining 18 patients. There was no difference between the two groups for age, duration of DRBAs treatment, UPDRS III, tremor, rigidity, and bradykinesia subscores for upper and lower limbs. Conversely, symmetry of parkinsonian signs and presence bucco-linguo-masticatory dyskinesias were more frequent in individuals with normal tracer binding. Imaging of the dopamine transporter may help to identify subjects with DIP secondary to a loss of dopamine nerve terminals. (c) 2008 Movement Disorder Society

Ibiza Absolute Calibration Experiment : Survey and Preliminary Results

International audienceWithin the framework of a project comprising part of the Spanish Space Program related to the JASON-1 CNES (Centre National d'Etudes Spatiales)/NASA (National Aeronautics and Space Administration) mission, a campaign was conducted from June 9-17, 2003, on the Absolute Calibration Site of the island of Ibiza. The objective was to determine the local marine geoid slope under the ascending (187) and descending (248) Jason-1 ground tracks, in order to allow a better extrapolation of the open-ocean altimetric data with on-shore tide gauge locations, and thereby improve the overall precision of the calibration process. For this we have used a catamaran with two GPS antennas onboard, following the Corsica/Senetosa design (Bonnefond et al. 2003a). Five GPS reference stations were deployed in order to reduce the distance between the areas covered by the catamaran and the fixed GPS receiver used in the kinematic process. The geodetic activities (e.g., GPS, leveling) have enabled the building of a very accurate (few mm) network in a reference frame compatible with the satellite altimetry missions (ITRF 2000). The GPS kinematic data were processed using two different software programmes, allowing checking of the consistency of the solutions. If the standard deviation of the differences (3.3 cm) is close to the kinematic process precision, they exhibit some large values (up to 14 cm). These large discrepancies have been reduced using a weighting based on the crossover differences. Inasmuch as the distances between the tide gauges and the areas covered by the GPS catamaran were becoming large, we have used the MOG2D ocean model (Carregravere and Lyard 2003) to correct the sea surface from tides. In the farthest areas, the crossover differences show an improvement by a factor of two. Finally, we also present preliminary results on Jason-1 altimeter calibration using the derived marine geoid. From this analysis, the altimeter bias is estimated to be 120 ± 5 mm. The quality of this first result validates the whole GPS-based marine geoid processing, for which the accuracy is estimated to be better than 3 cm rms at crossovers