933 research outputs found

    Assessing the adoption and impact of organic and fair trade certification of pepper in India

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    The role of the corticomotorneurons in pathogenesis of amyotrophic lateral sclerosis

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    Amyotrophic lateral sclerosis (ALS) is a progressive, degenerative disease of the motor system clinically defined by the presence of upper and lower motor neuron (LMN) signs. The site of onset of pathophysiology within the motor system in ALS remains unresolved and this thesis examines the role of the corticomotor neuron in the pathogenesis of ALS. The diagnostic utility of the split-hand sign in ALS involving preferential wasting of the ‘thenar’ group of intrinsic hand muscles namely the abductor pollicis brevis (APB) and first dorsal interosseous (FDI) was established by recording the split-hand index (SI) which was noted to reliably differentiate ALS from mimic neuromuscular disorders. The cortical and axonal excitability characteristics of the ‘thenar’ muscles namely the APB and FDI was compared with the hypothenar abductor digiti minimi (ADM) with threshold tracking transcranial magnetic stimulation (TMS) studies revealing cortical hyperexcitability to be a feature of ALS pronounced over the ‘thenar’ muscles while axonal hyperexcitability while a feature of ALS, did not selectively affect the prominently wasted ‘thenar’ muscles. Cortical hyperexcitability was also noted to precede the development of lower motor neuron dysfunction in a clinically and neurophysiologically normal APB muscle. The selective vulnerability of muscles in ALS was further defined by the split hand plus sign with a greater degree of cortical hyperexcitability over the preferentially wasted APB muscle in ALS patients when compared with a similarly innervated and relatively preserved flexor pollicis longus (FPL) muscle. In summary, corticomotorneuronal hyperexcitability as a marker of corticomotorneuronal dysfunction predominates over the muscles which are preferentially wasted in ALS and precedes evidence of lower motor neuron loss. The findings presented in this thesis support the primacy of the corticomotor neuron in the pathogenesis of the split hand phenomenon and suggest a mechanism for the pathogenesis of ALS

    Rage for Order : The British Empire and the Origins of International Law, 1800–1850, written by Lauren Benton and Lisa Ford

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    Reviewed book: Lauren Benton and Lisa Ford, Rage for Order. The British Empire and the Origins of International Law, 1800–1850. Cambridge, MA: Harvard University Press, 2016, 288 pp.; ISBN: 9780674737464, $39.95.Peer reviewe

    Negotiating Subjection : The Political Economy of Protection in the Iraqi Mandate (1914-1932)

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    The Mandate System provided a viable means for protecting European interests (without annexation), embedding the principle of foreign property protection as the basis for future relations between capital exporting and importing states. At the same time, the Mandates also protected the non-European Mandate inhabitants in preparation for their emancipation by introducing welfare measures, development, and ‘order’ that could support the protection of (foreign) property. The Iraqi example best explicates how the Mandate System uniquely combined vestiges of older imperial protection models and a future model for newly emancipated states, demonstrating the fluidity between the imperial and the international. I argue that such a fluidity helped facilitate a reciprocal causality between protecting people and protecting property, where protecting Iraqis facilitated British propertied interests. Equally, by separating the protection of people and property, I show how political self-determination of Mandate inhabitants remained distinct from their economic emancipation. Through these arguments, I demonstrate how protection of people and property was divergent and mutually constitutive.Peer reviewe
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