CLINICAL EVALUATION OF STEM BARK POWDER OF SHIGRU (MORINGA OLEIFERA LAM.) IN DYSLIPIDEMIA

In recent times drastic changes have taken place in dietary habits and mode of life style which has resulted in precipitation of various metabolic diseases. One such alarming condition, which is on a high rise in the society, is Dyslipidemia. Since the pathology has a clear link with a person’s life style, the body demands a more holistic approach in treatment, hence indigenous system of medicine especially herbal preparations can play major role in finding a safe, simple and cost effective solution for the management of Dyslipidemia. Shigru botanically identified as Moringa oleifera Lam. is one of such commonly available plant which is greatly praised for its Medoghna property in various Nighantus.A clinical study of Shigru twak (stem bark) was conducted on 30 patients at OPD level of Government Ayurveda College Hospital, Tripunithura, Kerala. Shigru stem bark powder (Choornam) was given in the form of capsule, in a dose of 3gm per day along with lukewarm water before food for a period of 45 days. Assessment based on blood lipid levels and clinical features was done before and after treatment. The results were statistically analyzed. After the intervention Total Cholesterol, Serum LDL, Serum VLDL, Serum Triglyceride and Body weight were significantly reduced. On symptomatic evaluation the drug was significantly effective in reducing heaviness of body, chest pain, excessive sleep, excessive sweating, and breathlessness on exertion, palpitation and lethargy. The study revealed that Shigru twak is safe and effective in Dyslipidemia

CORRELATIVE STUDY OF PRAKRITI WITH SANDHIVATA

Prakriti is the health profile or unique psychosomatic temperament of an individual encompassing his or her physical, functional and behavioural characteristics. Prakriti is not only an instrument to examine the patient but also influences the onset, occurrence, pathogenesis, diagnosis, prognosis and management of a patient. Among the various specific characteristics of Ayurveda, the knowledge of ‘Prakriti’ is at the top. Charaka, while directing tenfold examination of a patient (Dasvidh Pariksha), has counted ‘Prakriti’ on the top. Prakriti is most important in achieving the goal of Ayurveda, i.e. the maintenance of health of a healthy individual and cure of a diseased person. Keeping the knowledge of Prakriti in mind, a physician can suggest the person to follow up the day, night and seasonal regimens for the maintenance of health. Not only this, a diseased person can be easily managed by the knowledge of the Prakriti in the diagnosis as well as treatment. The knowledge of Prakriti eases the process of management of a disease because according to Ayurvedic concept, no disease in the body is possible without involvement of Dosha and the management is the reestablishment of Doshas in their normal state.For the purpose of present study, 30 patients of Sandhivata were selected from OPD and IPD of Ayurvedic and Unani Tibbia College Hospital and from Multi-Speciality Hindustani Dawakhana, Delhi having complaints related to ‘Sandhivata as per the “criteria for the selection of the patients” given below. On the basis of clinical examination (signs & symptoms) and necessary investigation (X-ray of the involved joints), the diagnosis of Sandhivata was established, then the patients were included in the study. The Prakriti of each patient was identified with the help of standard proforma, based on various signs & symptoms presented by various Ayurvedic authors for this purpose. The study revealed that Sandhivata has predominance in Vata pradhan prakriti due to Samanaya siddhanta

Effect of melatonin addition in ovulation induction protocols with clomiphene citrate in management of infertility

Background: About 10-12% of couples are unable to conceive by natural means despite concerted efforts and these figures have risen in past few decades. In recent years, effect of oxidative stress on the fertility has been widely recognised. Oxidative stress has been known to affect both male and female fertility reducing sperm count and motility in men, and affecting ovum reserve and quality in women. Melatonin is the secretion of the pineal gland responsible for circadian sleep rhythm has also shown to be good antioxidant. Aim and objective of current study was to study effect of melatonin addition to clomiphene citrate for induction of ovulation with a view to improve conception rates.Methods: This was a retrospective analysis of 52 women with infertility who were given clomiphene citrate with melatonin. Ovulation, conception rates and pregnancy outcomes were noted.Results: We observed 77.8%ovulation rates, and a significantly better conception and live birth rates.Conclusions: Melatonin, as an anti-oxidant may improve, conception and live birth rates when added to clomiphene citrate induction protocols

Unusual metastasis of medullary thyroid carcinoma to the breast: A cytological and histopathological correlation

Breast metastases are a relatively rare condition and account for approximately 0.5–2% of all breast tumors. Recognition of metastatic tumors in the breast is important because it would prevent unnecessary mutilating surgery and would lead to appropriate treatment of the primary tumor. Breast metastases from medullary thyroid cancer (MTC) are very rare with only 21 reported cases in the literature. Some MTCs mimic primary invasive lobular carcinoma of the breast histopathologically and radiologically, making the distinction between the two diagnostically challenging. We present the case of a 45-year-old female presenting with a lump breast, which was later found out to be metastasis from medullary carcinoma thyroid