Optimizing epilepsy treatment in children, adults and elderly: clinical perspectives

Epilepsy is a common neurological condition among all age groups. Its diagnosis depends on clinical history and is supported by investigations like electroencephalograph and magnetic resonance imaging. In children, febrile seizures and juvenile myoclonic seizures are common. In adults and elderly, epilepsy could be new onset or present since childhood. Several antiseizure medications (ASMs) are available for treatment of epilepsy. Each of these drugs has different advantages as well as limitations. Several factors including patient related factors (e. g. age, comorbidities, and gender), seizure characteristics and epilepsy type, and drug related factors (namely, pharmacokinetics, pharmacodynamics, efficacy, side effects, and risk of drug-drug interactions) are considered while selecting drug therapy. There are concerns related to teratogenicity due to pharmacotherapy in females of child-bearing potential. Elderly patients also need special considerations while selecting an appropriate treatment option for epilepsy. Advisory board meetings with a group of expert neurologists were conducted at eight cities across India to gain clinical insights on management of epilepsy in different age groups. Consensus was supported by relevant literature obtained from PubMed and Google scholar using the keywords ‘epilepsy’, ‘diagnosis’, ‘children’, ‘adults’, ‘elderly’, and ‘management’. According to the experts, choice of appropriate ASM is driven by patient- and drug-related factors and seizure characteristics. In India, valproate remains a commonly prescribed agent except in females of childbearing age. Levetiracetam is preferred because of its safety profile whereas clobazam is an effective initial add-on therapy. Newer drugs are largely useful as adjuvants

Sugarcane Bagasse-Derived Activated Carbon- (AC-) Epoxy Vitrimer Biocomposite: Thermomechanical and Self-Healing Performance

Vitrimeric materials have emerged as fascinating and sustainable materials owing to their malleability, reprocessability, and recyclability. Sustainable vitrimeric materials can be prepared by reinforcing polymeric matrix with bioderived fillers. In the current work, a sustainable vitrimer is prepared by incorporating biomass-derived activated carbon (AC) filler into the epoxy matrix to achieve enhanced thermal and mechanical properties. Thus, prepared biocomposite vitrimers demonstrate a lower-temperature self-healing (70°C for 5 min) via disulfide exchanges, compared to the pristine epoxy vitrimers (80°C for 5 min). Significantly, the self-healing performances have been studied extensively with the flexural studies; and changes in material healing efficiency have been demonstrated based on the observed changes in modulus

<b>Site Suitability for turmeric production in India </b><b></b><b>—</b><b> A GIS interpretation</b>

142-147India has 1,49,410 hectares area under turmeric cultivation with a total annual production of 527,960 tonnes. The compound growth rate of turmeric area is 6.30 and production is 3.37 when comparing 2000 levels over those of 1970. It shows that the increase in area is not having significant effect over the production rate. In the present paper the suitability maps and area productivity graphs are given to show, the position of turmeric in the important turmeric growing states. It was found that site suitability is an important factor to determine the productivity of the crop. A highly suitable location may not result in larger yields than suitable or marginally suitable areas. Suitability maps are useful to determine areas which will have the greatest success for growing a particular crop in a region

Sugarcane Bagasse-Derived Activated Carbon- (AC-) Epoxy Vitrimer Biocomposite: Thermomechanical and Self-Healing Performance

Vitrimeric materials have emerged as fascinating and sustainable materials owing to their malleability, reprocessability, and recyclability. Sustainable vitrimeric materials can be prepared by reinforcing polymeric matrix with bioderived fillers. In the current work, a sustainable vitrimer is prepared by incorporating biomass-derived activated carbon (AC) filler into the epoxy matrix to achieve enhanced thermal and mechanical properties. Thus, prepared biocomposite vitrimers demonstrate a lower-temperature self-healing (70°C for 5 min) via disulfide exchanges, compared to the pristine epoxy vitrimers (80°C for 5 min). Significantly, the self-healing performances have been studied extensively with the flexural studies; and changes in material healing efficiency have been demonstrated based on the observed changes in modulus

Evolutionary Patterns of Flexible Automation and Performance: A Longitudinal Study

This study presents a longitudinal analysis of patterns of investment in advanced manufacturing technologies (AMT) and financial performance. Investments in AMT from 112 manufacturing plants in the metal-working industries are examined. Data were collected via a mail survey administered to 202 plants in 1994, and readministered to 112 of the same plants in 1996. This study seeks to fill a void in the area of technology management, which is comprised primarily of cross-sectional studies that do not address the dynamic nature of investments in technology. Four major conclusions are drawn from the data. First, several individual technologies have higher investments in 1996 than in 1994. In particular, electronic mail has the largest increase in investment, a finding that suggests that manufacturing firms are finding ways to take advantage of the exploding potential of electronic communication. Our second conclusion is that plants invest in technology in an incremental fashion over time rather than using an all-or-nothing approach. Plants with low investments follow one of three technology strategies as their investments in AMTs evolve: (1) continued low investment, (2) investment primarily in design-based technologies, or (3) equalized investment in design, manufacturing, and administrative AMTs. Third, analysis of the degree of manufacturing involvement in developing business strategy indicates that plants that have a more proactive role for manufacturing invest greater resources in AMTs. Finally, while AMT investment was not positively associated with performance in a cross-sectional analysis, longitudinal analysis of data collected two years later does reveal a relationship. In short, the analysis supports the proposition that there is a lag between initial investment and resulting performance improvements.advanced manufacturing technology, technology management, operations strategy, longitudinal research, empirical research