DON AGUSTÍN NIETO CABALLERO ANDANTE DE LA EDUCACIÓN

Entre los pocos maestros inolvidables del autor figura don Agustin Nieto Caballero, un ilustre educador bogotano que, a partir de las teorias psicologicas, pedagogicas y filosoficas de Jhon Dewey, Ovide Decroly, Maria Montesori y Henri Bergson, instituyo en Colombia la Escuela Nueva, y fundo con otros colombianos no menos notables, en 1914, el Gimnasio Moderno que tanta influencia ha tenido en el desarrollo edeucativo del pais y de America Latina. El presente articulom, a la vez que destaca el aporte de Nieto Caballero a la luz de las ideas fundamentales de sus mentores, rinde homenaje al Maestro que hizo posible una audaz renovacion de la educacion colombiana

Recovery of dialysis patients with COVID-19 : health outcomes 3 months after diagnosis in ERACODA

Background. Coronavirus disease 2019 (COVID-19)-related short-term mortality is high in dialysis patients, but longer-term outcomes are largely unknown. We therefore assessed patient recovery in a large cohort of dialysis patients 3 months after their COVID-19 diagnosis. Methods. We analyzed data on dialysis patients diagnosed with COVID-19 from 1 February 2020 to 31 March 2021 from the European Renal Association COVID-19 Database (ERACODA). The outcomes studied were patient survival, residence and functional and mental health status (estimated by their treating physician) 3 months after COVID-19 diagnosis. Complete follow-up data were available for 854 surviving patients. Patient characteristics associated with recovery were analyzed using logistic regression. Results. In 2449 hemodialysis patients (mean ± SD age 67.5 ± 14.4 years, 62% male), survival probabilities at 3 months after COVID-19 diagnosis were 90% for nonhospitalized patients (n = 1087), 73% for patients admitted to the hospital but not to an intensive care unit (ICU) (n = 1165) and 40% for those admitted to an ICU (n = 197). Patient survival hardly decreased between 28 days and 3 months after COVID-19 diagnosis. At 3 months, 87% functioned at their pre-existent functional and 94% at their pre-existent mental level. Only few of the surviving patients were still admitted to the hospital (0.8-6.3%) or a nursing home (∼5%). A higher age and frailty score at presentation and ICU admission were associated with worse functional outcome. Conclusions. Mortality between 28 days and 3 months after COVID-19 diagnosis was low and the majority of patients who survived COVID-19 recovered to their pre-existent functional and mental health level at 3 months after diagnosis

Clinical control of packed RBC transfusion in acute surgical pathology such as gastric dilation and volvulus in dogs

The main goal of the present work was the analysis of peripheral blood in case of surgical pathology in dogs with gastric dilation and volvulus as well as correction of post-operative state by RBC transfusion. Scientific supplies of domestic and foreign authors that influenced the use of blood transfusion and control of various types of correction in life-threatening conditions served as methodological basis of the scientific study. The studies used methods of clinical examination characterizing the pathogenetic aspects of the problem being studied. During the period of post-op observation of the animals anemia was detected on Day 1-7, thrombocytopenia on Day 1-3, as well as severe immunosuppression caused by the development of anesthesia and splenectomy, which was confirmed by lymphopenia and thrombocytopenia on Day 1-3. The study has shown that the use of packed red blood cells in the early post-op period reduces the severity of anemia, and the severity of the inflammatory process. Administration of donor red blood cells reduces immunosuppressive effect of splenectomy and effects of general anesthesia, triggers the production of platelets, reticulocytes, thereby stimulating cell proliferation to the reparative processes. The use of packed red blood cells in case of severe abdominal pathology in dogs in the post-op period is a promising direction for the development of hemotransfusion in the veterinary surgery

Analysis of dental implants' biointegration in animals

This article presents characterization study of new coatings for dental implants, defines their basic requirements, and discusses the prospects of thermal oxide coatings application in animals' dental implantology. Thermally oxidized implants, modified with nanoaggregates of flavonoids, possess a greater degree of osteointegration as compared with the implants without coating. It was revealed in vitro that during the research control period, fibroblasts were adherenced around the implants' blanks on samples with a nontoxic coating of polyazolidine ammonium modified by the hydrate flavonoids' halogen ions. It is revealed that the experimental implants do not exert inhibitory action on erythropoiesis and leukopoiesis. The lack of sharp fluctuations in the levels of calcium and phosphorus, the dynamics of bilirubin, creatinine and urea within the reference values, as well as the recovery of the initial level of aspartate transaminase, alanine aminotransferase and C-reactive protein in animals of the experimental group at the early stages indicate the absence of toxic influence of implants with thermally oxidized surface coated through induction heat treatment and modified by nanoaggregates of flavonoids. © 2016 Krasnikov et al

The morphological aspects of bone marrow of Guinea fowl of the Volga white breed in postembryonic ontogenesis.

The paper presents materials on age-related morphology of the bone marrow of Guinea fowl of the Volga white breed. The bone marrow is placed in the cancellous cells, and in the postembryonic period its absolute mass increases, and the relative weight, on the contrary, decreases. The highest content of the bone marrow in the skeleton of a Guinea fowl is observed in the period from the 1-st till the 60-th days of life. The volume of the bone marrow in the male Guinea fowl is higher than in the female Guinea fowl on 1,7+0,15%. The main mass of the bone marrow in a newborn Guinea fowl is placed in the peripheral skeleton, and more than 45% in the humeral, femoral and tibial bones. As for the axial skeleton, most of it is concentrated in the iliac bone and the lower jaw. Further the number of a bone marrow sharply increases and reaches a maximum to the 60-th day of life, consisting of 37.10+of 1.51% from the total content of the skeleton of a Guinea fowl. Then this figure stabilizes and to the 90-th day of life it consists of 34,90+1,89%. From the 180-th day of life the amount of a bone marrow in the skeleton begins to decrease and to the 365-th day it consists of only 23,10+of 1.11%. Microscopy of smears of a bone marrow finds an individual fat cells in it from the 60-th day of life. By the time of a puberty is observed a gradual replacement of a red marrow to the yellow and to 180-th day it is only 15,75+1,28%. By the 365-th of life a bone marrow is mostly yellow with a single foci of hematopoiesis in its structure, up to 8,31+1,56%

The Morphological Aspects of Bone Marrow of Guinea Fowl of the Volga White Breed in Postembryonic Ontogenesis

The paper presents materials on age-related morphology of the bone marrow of Guinea fowl of the Volga white breed. The bone marrow is placed in the cancellous cells, and in the postembryonic period its absolute mass increases, and the relative weight, on the contrary, decreases. The highest content of the bone marrow in the skeleton of a Guinea fowl is observed in the period from the 1-st till the 60-th days of life. The volume of the bone marrow in the male Guinea fowl is higher than in the female Guinea fowl on 1,7+0,15%. The main mass of the bone marrow in a newborn Guinea fowl is placed in the peripheral skeleton, and more than 45% in the humeral, femoral and tibial bones. As for the axial skeleton, most of it is concentrated in the iliac bone and the lower jaw. Further the number of a bone marrow sharply increases and reaches a maximum to the 60-th day of life, consisting of37.10+of 1.51% from the total content of the skeleton of a Guinea fowl. Then this figure stabilizes and to the 90-th day of life it consists of 34,90+1,89%. From the 180-th day of life the amount of a bone marrow in the skeleton begins to decrease and to the 365-th day it consists of only 23,10+of 1.11%. Microscopy of smears of a bone marrow finds an individual fat cells in it from the 60-th day of life. By the time of a puberty is observed a gradual replacement of a red marrow to the yellow and to 180-th day it is only 15,75+1,28%. By the 365-th of life a bone marrow is mostly yellow with a single foci of hematopoiesis in its structure, up to 8,31+1,56%

Анализ биоинтеграции дентальных имплантатов у животных.

This article presents characterization study of new coatings for dental implants, defines their basic requirements, and discusses the prospects of thermal oxide coatings application in animals' dental implantology. Thermally oxidized implants, modified with nanoaggregates of flavonoids, possess a greater degree of osteointegration as compared with the implants without coating. It was revealed in vitro that during the research control period, fibroblasts were adherenced around the implants' blanks on samples with a nontoxic coating of polyazolidine ammonium modified by the hydrate flavonoids' halogen ions. It is revealed that the experimental implants do not exert inhibitory action on erythropoiesis and leukopoiesis. The lack of sharp fluctuations in the levels of calcium and phosphorus, the dynamics of bilirubin, creatinine and urea within the reference values, as well as the recovery of the initial level of aspartate transaminase, alanine aminotransferase and C-reactive protein in animals of the experimental group at the early stages indicate the absence of toxic influence of implants with thermally oxidized surface coated through induction heat treatment and modified by nanoaggregates of flavonoids. © 2016 Krasnikov et al.В данной статье дается характеристика исследования новых покрытий для дентальных имплантатов, определяются их основные требования и обсуждаются перспективы применения термооксидных покрытий в дентальной имплантологии животных. Термически окисленные имплантаты, модифицированные наноагрегатами флавоноидов, обладают большей степенью остеоинтеграции по сравнению с имплантатами без покрытия. In vitro было обнаружено, что в течение контрольного периода исследования фибробласты были прикреплены вокруг заготовок имплантатов на образцах с нетоксичным покрытием из полиазолидинаммония, модифицированного ионами галогена гидрата флавоноидов. Выявлено, что экспериментальные имплантаты не оказывают ингибирующего действия на эритропоэз и лейкопоэз. Отсутствие резких колебаний уровней кальция и фосфора, динамики билирубина, креатинина и мочевины в пределах контрольных значений, а также восстановление исходного уровня аспартат-трансаминазы, аланинаминотрансферазы и С-реактивного белка у животных Опытные группы на ранних стадиях указывают на отсутствие токсического влияния имплантатов с термически окисленной поверхностью, покрытой за счет индукционной термообработки и модифицированной наноагрегатами флавоноидов

Клинический контроль трансфузионного переливания эритроцитарной массы при острой хирургической патологии, такой как дилатация желудка и вольвулус у собак.

The main goal of the present work was the analysis of peripheral blood in case of surgical pathology in dogs with gastric dilation and volvulus as well as correction of post-operative state by RBC transfusion. Scientific supplies of domestic and foreign authors that influenced the use of blood transfusion and control of various types of correction in life-threatening conditions served as methodological basis of the scientific study. The studies used methods of clinical examination characterizing the pathogenetic aspects of the problem being studied. During the period of post-op observation of the animals anemia was detected on Day 1-7, thrombocytopenia on Day 1-3, as well as severe immunosuppression caused by the development of anesthesia and splenectomy, which was confirmed by lymphopenia and thrombocytopenia on Day 1-3. The study has shown that the use of packed red blood cells in the early post-op period reduces the severity of anemia, and the severity of the inflammatory process. Administration of donor red blood cells reduces immunosuppressive effect of splenectomy and effects of general anesthesia, triggers the production of platelets, reticulocytes, thereby stimulating cell proliferation to the reparative processes. The use of packed red blood cells in case of severe abdominal pathology in dogs in the post-op period is a promising direction for the development of hemotransfusion in the veterinary surgery.Основной целью настоящей работы являлся анализ периферической крови при хирургической патологии у собак с расширением желудка и вольвулусом, а также коррекция послеоперационного состояния при переливании эритроцитов. В качестве методологической основы научного исследования послужили научные материалы отечественных и зарубежных авторов, оказавшие влияние на применение переливания крови и контроль различных видов коррекции при угрожающих жизни состояниях. В исследованиях использовались методы клинического обследования, характеризующие патогенетические аспекты изучаемой проблемы. В течение периода послеоперационного наблюдения у животных была выявлена анемия на 1-7 день, тромбоцитопения на 1-3 день, а также выраженная иммуносупрессия, вызванная развитием анестезии и спленэктомии, что было подтверждено лимфопенией и тромбоцитопенией на день 1-3. Исследование показало, что использование эритроцитарной массы в раннем послеоперационном периоде снижает степень анемии и степень воспалительного процесса. Введение донорских эритроцитов снижает иммуносупрессивный эффект спленэктомии и эффекты общей анестезии, запускает производство тромбоцитов, ретикулоцитов, тем самым стимулируя пролиферацию клеток к репаративным процессам. Использование упакованных эритроцитов при тяжелой патологии брюшной полости у собак в послеоперационном периоде является перспективным направлением развития гемотрансфузии в ветеринарной хирургии

Special aspects of the pathohistological diagnostics of familial shar-pei amyloidosis

Introduction: Familial Shar-Pei amyloidosis is an autoinflammatory systemic disease characterized by pathological synthesis of the fibrillary protein in the cells of the reticuloendothelial system, followed by amyloid formation. The purpose of our research is mainly focused on the investigation of specific structural histological changes in kidneys, liver, and spleen of the Shar-Pei dogs suffering from familial amyloidosis. Materials and Methods: The studies included autopsy and post-mortem examination of the Shar-Pei dogs with the presumptive diagnosis of familial amyloidosis or other diagnoses. Samples of kidney, liver, and spleen tissues of all cadavers were collected for histological examination. Results: Our studies showed that amyloid was formed within the ground substance of the connective tissue. Early amyloid deposits were observed in the spleen samples, providing the pathomorphological marker of the initial stage of the process generalization, whereas during the later stages, amyloid was found in kidneys, liver, and myocardium. Gradually increasing amyloid deposits lead to compression and atrophy of the parenchymal cells, sclerosis, and multiple organ dysfunction syndrome, manifesting as a wide range of clinical signs. Discussion: As a result of the conducted post-mortem examination, we have revealed systemic amyloidosis in the cadavers of the animals, initially admitted with various pathologies, which proves the importance and relevance of timely diagnostics, detection of clinical manifestations, and latent forms of the condition. Histological examination is one of the most accurate diagnostic methods for this pathology