165 research outputs found

    Translation Technique and Versional Evidence: The Syriac Peshitta Version of Colossians as a Witness to Its Greek Text

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    The Syriac Peshitta version of the New Testament holds great potential for NT textual criticism, but its value to this field is partially dependent upon the ability to deduce the particularities of the Greek text from which it was translated. To assess this ability, a thorough understanding of translation technique in each NT book is required. Toward such an end, this thesis provides a detailed study of the translation technique of Peshitta Colossians (PCol) and an evaluation thereof as a witness to its Greek Vorlage. I argue that the translation technique of PCol does not consistently allow confident conclusions to be reached about the specifics of its underlying Greek text, but rather that the Syriac of PCol sometimes may have been made from a range of possible Greek readings. This is not always recognized when editors of Greek NT editions cite PCol in the critical apparatus as a witness to certain readings. I demonstrate this by a systematic study of the citations of PCol in the 28th revised edition of the Nestle-Aland Novum Testamentum Graece (NA28), in which I conclude that no fewer than eleven citations in the NA28 are illegitimate on translational grounds, with several more requiring further clarification. Chapter I contains a review of the pertinent literature and an overview of the project. In Chapter II, I lay out the three methodologies implemented in this study. Chapter III is a detailed presentation of the translation technique in PCol. In Chapter IV, I apply the conclusions about translation technique to an evaluation of PCol as a witness to its Greek source text and I analyze each citation of PCol in the NA28 critical apparatus. Finally, Chapter V contains conclusions about suggested changes to citations of PCol in critical apparatuses as well as how this study should affect the implementation of versional evidence in NT textual criticism. The arguments I advance in this Thesis stand to improve upon the approach to employing versions as witnesses to their Greek texts and to clarify the place of the Peshitta in the critical apparatus of future editions of the Greek text of Colossians

    Millimeter-wave ozone measurements for the network for the detection of stratospheric change

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    The primary research objective is to initiate long-term monitoring of stratospheric ozone with a ground-based millimeter-wave spectrometer, the first of several such instruments projected to be part of the Network for the Detection of Stratospheric Change. The ultimate goal of this monitoring is twofold. First, to detect any secular trend in stratospheric ozone abundance, whether of natural or anthropogenic origin and, second, to provide ground-truth validation for existing and future satellite measurements of ozone. With this goal in mind, a more immediate objective is to validate the millimeter-wave measurements by tests of the instrument, internal consistency tests on the data, and most importantly, by intercomparison with all other available ozone measurements. The validation process is expected to lead to refinements in the instrument and its operating procedures and in the data analysis. The final objective is to perform short-term scientific studies with the data, including studies of the ozone diurnal and seasonal variations, and comparison of ozone variations with changes in other geophysical parameters, notably temperature and water vapor. Routine observations are now ongoing; these will allow continuing intercomparisons with the Stratospheric Aerosol and Gas Experiment (SAGE II) and one of the lidars, which is permanently on site. The experience gained during the Stratospheric Ozone Intercomparison (STOIC) caused us to refine our calibration procedures and identify the need for internal shielding of the millimeter receiver from radio frequency interference. Installation of this shielding is planned for the near future and should allow improvements in the instrument calibration and a higher signal-to-noise ratio, both of which will result in improved measurement precision

    The Aging Kidney: Increased Susceptibility to Nephrotoxicity

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    Three decades have passed since a series of studies indicated that the aging kidney was characterized by increased susceptibility to nephrotoxic injury. Data from these experimental models is strengthened by clinical data demonstrating that the aging population has an increased incidence and severity of acute kidney injury (AKI). Since then a number of studies have focused on age-dependent alterations in pathways that predispose the kidney to acute insult. This review will focus on the mechanisms that are altered by aging in the kidney that may increase susceptibility to injury, including hemodynamics, oxidative stress, apoptosis, autophagy, inflammation and decreased repair

    Error analysis for the ground-based microwave ozone measurements during STOIC

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    We present a formal error analysis and characterization of the microwave measurements made during the Stratospheric Ozone Intercomparison Campaign (STOIC). The most important error sources are found to be determination of the tropospheric opacity, the pressure-broadening coefficient of the observed line, and systematic variations in instrument response as a function of frequency ('baseline'). Net precision is 4-6% between 55 and 0.2 mbar, while accuracy is 6-10%. Resolution is 8-10 km below 3 mbar and increases to 17km at 0.2 mbar. We show the 'blind' microwave measurements from STOIC and make limited comparisons to other measurements. We use the averaging kernels of the microwave measurement to eliminate resolution and a priori effects from a comparison to SAGE 2. The STOIC results and comparisons are broadly consistent with the formal analysis

    Phenotypic profiles of cultured glomerular cells following repeated cycles of hydrocarbon injury

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    Phenotypic profiles of cultured glomerular cells following repeated cycles of hydrocarbon injury.BackgroundThe glomerulus has been implicated as a target of hydrocarbon injury in vitro and in vivo. In the present studies, the phenotypic profiles of cultured rat glomerular cells (GCs) following repeated cycles of hydrocarbon injury were evaluated. Cultured GCs were incubated for 24 hours with benzo[a]pyrene (BaP; 3 μmol/L), a prototypical polycyclic aromatic hydrocarbon, and were allowed to recover overnight before two additional cycles of chemical challenge during serial propagation in vitro. At the end of this regimen, control cultures were characterized by predominance of fusiform cells that grew in “hills and valleys,” while GCs subjected to hydrocarbon injury displayed an epithelial morphology characterized by a rounded, polygonal shape clearly distinct from that normally exhibited by glomerular mesangial cells (GMCs) in culture.MethodsIndirect immunofluorescent detection of cell markers was conducted to identify cells of mesenchymal or epithelial origin. Measurements of DNA synthesis and cell number were performed to determine proliferative capacities of the different cell types in response to hydrocarbon challenge.ResultsImmunofluorescence studies revealed that control GC cultures contained mostly α-smooth muscle (SM) actin-positive cells, with a few (5.1%± 2.6) E-cadherin–positive cells occasionally identified. In contrast, BaP-treated cultures exhibited a mixed cell population in which E-cadherin–positive cells were predominant (66.6%± 4.1). Single-cell cloning of naive cultures of GCs yielded four clones, three of which exhibited a fusiform morphology and were α-SM actin positive (SCC 1 through SCC 3) and one (SCC 4E) that exhibited epithelial characteristics similar to those found in hydrocarbon-treated cultures. Immunofluorescence studies showed that epithelial cells in hydrocarbon-treated cultures, as well as SCC 4E-derived clones, were vimentin positive and cytokeratin negative, characteristics similar to glomerular visceral epithelial cells (GVECs). DNA synthesis and cell proliferation in clone SCC 1 were decreased following acute BaP challenge, while growth rates in SCC 4E-derived clones were unaffected by hydrocarbon injury. Repeated cycles of hydrocarbon challenge in clonal populations yielded different profiles of DNA synthesis, with significant decreases in SCC 1 and no changes in SCC 4E.ConclusionsThese observations suggest that hydrocarbon injury induces differential responses in cells of the glomerulus, resulting in inhibition of GMCs and selective growth advantage of GVECs. These alterations are reminiscent of critical events described in the pathogenesis of focal segmental glomerulosclerosis and raise important questions about the pathogenesis of hydrocarbon-induced nephropathies

    Very Shallow Water Bathymetry Retrieval from Hyperspectral Imagery at the Virginia Coast Reserve (VCR\u2707) Multi-Sensor Campaign

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    A number of institutions, including the Naval Research Laboratory (NRL), have developed look up tables for remote retrieval of bathymetry and in-water optical properties from hyperspectral imagery (HSI) [6]. For bathymetry retrieval, the lower limit is the very shallow water case (here defined as \u3c 2m), a depth zone which is not well resolved by many existing bathymetric LIDAR sensors, such as SHOALS [4]. The ability to rapidly model these shallow water depths from HSI directly has potential benefits for combined HSI/LIDAR systems such as the Compact Hydrographic Airborne Rapid Total Survey (CHARTS) [10]. In this study, we focused on the validation of a near infra-red feature, corresponding to a local minimum in absorption (and therefore a local peak in reflectance), which can be correlated directly to bathymetry with a high degree of confidence. Compared to other VNIR wavelengths, this particular near-IR feature corresponds to a peak in the correlation with depth in this very shallow water regime, and this is a spectral range where reflectance depends primarily on water depth (water absorption) and bottom type, with suspended constituents playing a secondary role

    Microwave and Millimeter Wave Techniques

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    Contains reports on two research project.Joint Services Electronics Program (Contract DAABO7-76-C-1400

    Model/data comparisons of ozone in the upper stratosphere and mesosphere

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    We compare ground-based microwave observations of ozone in the upper stratosphere and mesosphere with daytime observations made from the SME (Solar Mesosphere Explorer) satellite, with nighttime data from the LIMS instrument, and with a diurnal photochemical model. The results suggest that the data are all in reasonable agreement and that the model-data discrepancy is much less than previously thought, particularly in the mesosphere. This appears to be due to the fact that the latest data are lower than earlier reports and the updated model predicts more ozone than older versions. The model and the data agree to within a factor of 1.5 at all altitudes and typically are within 20 percent
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