Self-Trapping, Quantum Tunneling and Decay Rates for a Bose Gas with Attractive Nonlocal Interaction

We study the Bose-Einstein condensation for a cloud of $^7$Li atoms with attractive nonlocal (finite-range) interaction in a harmonic trap. In addition to the low-density metastable branch, that is present also in the case of local interaction, a new stable branch appears at higher densities. For a large number of atoms, the size of the cloud in the stable high-density branch is independent of the trap size and the atoms are in a macroscopic quantum self-trapped configuration. We analyze the macroscopic quantum tunneling between the low-density metastable branch and the high-density one by using the istanton technique. Moreover we consider the decay rate of the Bose condensate due to inelastic two- and three-body collisions.Comment: 5 pages, 4 figures, submitted to Phys. Rev.

Beyond Gross-Pitaevskii:local density vs. correlated basis approach for trapped bosons

We study the ground state of a system of Bose hard-spheres trapped in an isotropic harmonic potential to investigate the effect of the interatomic correlations and the accuracy of the Gross-Pitaevskii equation. We compare a local density approximation, based on the energy functional derived from the low density expansion of the energy of the uniform hard sphere gas, and a correlated wave function approach which explicitly introduces the correlations induced by the potential. Both higher order terms in the low density expansion, beyond Gross-Pitaevskii, and explicit dynamical correlations have effects of the order of percent when the number of trapped particles becomes similar to that attained in recent experiments.Comment: Revtex, 2 figure

Beyond Gross-Pitaevskii:local density vs. correlated basis approach for trapped bosons

We study the ground state of a system of Bose hard-spheres trapped in an isotropic harmonic potential to investigate the effect of the interatomic correlations and the accuracy of the Gross-Pitaevskii equation. We compare a local density approximation, based on the energy functional derived from the low density expansion of the energy of the uniform hard sphere gas, and a correlated wave function approach which explicitly introduces the correlations induced by the potential. Both higher order terms in the low density expansion, beyond Gross-Pitaevskii, and explicit dynamical correlations have effects of the order of percent when the number of trapped particles becomes similar to that attained in recent experiments.Comment: Revtex, 2 figure

Low energy and dynamical properties of a single hole in the t-Jz model

We review in details a recently proposed technique to extract information about dynamical correlation functions of many-body hamiltonians with a few Lanczos iterations and without the limitation of finite size. We apply this technique to understand the low energy properties and the dynamical spectral weight of a simple model describing the motion of a single hole in a quantum antiferromagnet: the $t-J_z$ model in two spatial dimension and for a double chain lattice. The simplicity of the model allows us a well controlled numerical solution, especially for the two chain case. Contrary to previous approximations we have found that the single hole ground state in the infinite system is continuously connected with the Nagaoka fully polarized state for $J_z \to 0$. Analogously we have obtained an accurate determination of the dynamical spectral weight relevant for photoemission experiments. For $J_z=0$ an argument is given that the spectral weight vanishes at the Nagaoka energy faster than any power law, as supported also by a clear numerical evidence. It is also shown that spin charge decoupling is an exact property for a single hole in the Bethe lattice but does not apply to the more realistic lattices where the hole can describe closed loop paths.Comment: RevTex 3.0, 40 pages + 16 Figures in one file self-extracting, to appear in Phys. Rev

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. © 2022, The Author(s)