5,145 research outputs found
Deriving preference-based single indices from non-preference based condition-specific instruments: Converting AQLQ into EQ5D indices
Suppose that one has a clinical dataset with only non-preference-based QOL data, and that one nevertheless would like to perform a cost/QALY analysis. This study reports on some efforts to establish a "mapping" relationship between AQLQ (a non-preference-based QOL instrument for asthma) and EQ5D (a preference-based generic instrument). Various methods are described in terms of associated assumptions regarding the measurement properties of the instruments. This is followed by empirical mapping, based on regressing EQ5D on AQLQ. Six main regression models and two supplementary models are identified, and the regressions carried out. Performance of each model is explored in terms of goodness of fit between observed and predicted values, and of robustness of predictions on external data. The results show that it is possible to predict mean EQ5D indices given AQLQ data. The general implications for methods of mapping non-preference-based instruments onto preference-based measures are discussed
Deriving preference-based single indices from non-preference based condition-specific instruments: converting AQLQ into EQ5D indices
Suppose that one has a clinical dataset with only non-preference-based QOL data, and that one nevertheless would like to perform a cost/QALY analysis. This study reports on some efforts to establish a “mapping” relationship between AQLQ (a non-preference-based QOL instrument for asthma) and EQ5D (a preference-based generic instrument). Various methods are described in terms of associated assumptions regarding the measurement properties of the instruments. This is followed by empirical mapping, based on regressing EQ5D on AQLQ. Six main regression models and two supplementary models are identified, and the regressions carried out. Performance of each model is explored in terms of goodness of fit between observed and predicted values, and of robustness of predictions on external data. The results show that it is possible to predict mean EQ5D indices given AQLQ data. The general implications for methods of mapping non-preference-based instruments onto preference-based measures are discussed.EQ5D; AQLQ; mapping
On the origin of \gamma-ray emission in \eta\ Carina
\eta\ Car is the only colliding-wind binary for which high-energy \gamma\
rays are detected. Although the physical conditions in the shock region change
on timescales of hours to days, the variability seen at GeV energies is weak
and on significantly longer timescales. The \gamma-ray spectrum exhibits two
features that can be interpreted as emission from the shocks on either side of
the contact discontinuity. Here we report on the first time-dependent modelling
of the non-thermal emission in \eta\ Car. We find that emission from primary
electrons is likely not responsible for the \gamma-ray emission, but
accelerated protons interacting with the dense wind material can explain the
observations. In our model, efficient acceleration is required at both shocks,
with the primary side acting as a hadron calorimeter, whilst on the companion
side acceleration is limited by the flow time out of the system, resulting in
changing acceleration conditions. The system therefore represents a unique
laboratory for the exploration of hadronic particle acceleration in
non-relativistic shocks.Comment: 5 pages, 4 figures, 1 table, accepted for publication in MNRAS
Letter
Fluorides, orthodontics and demineralization: a systematic review
Objectives: To evaluate the effectiveness of fluoride in preventing white spot lesion (WSL) demineralization during orthodontic treatment and compare all modes of fluoride delivery.
Data sources: The search strategy for the review was carried out according to the standard Cochrane systematic review methodology. The following databases were searched for RCTs or CCTs: Cochrane Clinical Trials Register, Cochrane Oral Health Group Specialized Trials Register, MEDLINE and EMBASE. Inclusion and exclusion criteria were applied when considering studies to be included. Authors of trials were contacted for further data.
Data selection: The primary outcome of the review was the presence or absence of WSL by patient at the end of treatment. Secondary outcomes included any quantitative assessment of enamel mineral loss or lesion depth.
Data extraction: Six reviewers independently, in duplicate, extracted data, including an assessment of the methodological quality of each trial.
Data synthesis: Fifteen trials provided data for this review, although none fulfilled all the methodological quality assessment criteria. One study found that a daily NaF mouthrinse reduced the severity of demineralization surrounding an orthodontic appliance (lesion depth difference –70.0 µm; 95% CI –118.2 to –21.8 µm). One study found that use of a glass ionomer cement (GIC) for bracket bonding reduced the prevalence of WSL (Peto OR 0.35; 95% CI 0.15–0.84) compared with a composite resin. None of the studies fulfilled all of the methodological quality assessment criteria.
Conclusions: There is some evidence that the use of a daily NaF mouthrinse or a GIC for bonding brackets might reduce the occurrence and severity of WSL during orthodontic treatment. More high quality, clinical research is required into the different modes of delivering fluoride to the orthodontic patient
The bactericidal activity of glutaraldehyde-impregnated polyurethane
Although glutaraldehyde is known to be bactericidal in solution, its potential use to create novel antibacterial polymers suitable for use in healthcare environments has not been evaluated. Here, novel materials were prepared in which glutaraldehyde was either incorporated into polyurethane using a simple “swell-encapsulation-shrink” method (hereafter referred to as “glutaraldehyde-impregnated polyurethane”), or simply applied to the polymer surface (hereafter referred to as “glutaraldehyde-coated polyurethane”). The antibacterial activity of glutaraldehyde-impregnated and glutaraldehyde-coated polyurethane samples was tested against Escherichia coli and Staphylococcus aureus. Glutaraldehyde-impregnated polyurethane resulted in a 99.9% reduction in the numbers of E. coli within 2 h and a similar reduction of S. aureus within 1 h, whereas only a minimal reduction in bacterial numbers was observed when the biocide was bound to the polymer surface. After 15 days, however, the bactericidal activity of the impregnated material was substantially reduced presumably due to polymerization of glutaraldehyde. Thus, although glutaraldehyde retains antibacterial activity when impregnated into polyurethane, activity is not maintained for extended periods of time. Future work should examine the potential of chemical modification of glutaraldehyde and/or polyurethane to improve the useful lifespan of this novel antibacterial polymer
Optical measurement of torque exerted on an elongated object by a non-circular laser beam
We have developed a scheme to measure the optical torque, exerted by a laser
beam on a phase object, by measuring the orbital angular momentum of the
transmitted beam. The experiment is a macroscopic simulation of a situation in
optical tweezers, as orbital angular momentum has been widely used to apply
torque to microscopic objects. A hologram designed to generate LG02 modes and a
CCD camera are used to detect the orbital component of the beam. Experimental
results agree with theoretical numerical calculations, and the strength of the
orbital component suggest its usefulness in optical tweezers for
micromanipulation.Comment: 6 pages, 7 figures, v2: minor typographical correction
Mesoscopic mechanism of exchange interaction in magnetic multilayers
We discuss a mesoscopic mechanism of exchange interaction in
ferromagnet-normal metal-ferromagnet multilayers. We show that in the case when
the metal's thickness is larger than the electron mean free path, the relative
orientation of magnetizations in the ferromagnets is perpendicular. The
exchange energy between ferromagnets decays with the metal thickness as a power
law
Pressure-Induced Insulating State in Ba1-xRExIrO3 (RE = Gd, Eu) Single Crystals
BaIrO3 is a novel insulator with coexistent weak ferromagnetism, charge and
spin density wave. Dilute RE doping for Ba induces a metallic state, whereas
application of modest pressure readily restores an insulating state
characterized by a three-order-of-magnitude increase of resistivity. Since
pressure generally increases orbital overlap and broadens energy bands, a
pressure-induced insulating state is not commonplace. The profoundly dissimilar
responses of the ground state to light doping and low hydrostatic pressures
signal an unusual, delicate interplay between structural and electronic degrees
of freedom in BaIrO3
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