7,887 research outputs found
Immune- and nonimmune-compartment-specific interferon responses are critical determinants of herpes simplex virus-induced generalized infections and acute liver failure
The interferon (IFN) response to viral pathogens is critical for host survival. In humans and mouse models, defects in IFN responses can result in lethal herpes simplex virus 1 (HSV-1) infections, usually from encephalitis. Although rare, HSV-1 can also cause fulminant hepatic failure, which is often fatal. Although herpes simplex encephalitis has been extensively studied, HSV-1 generalized infections and subsequent acute liver failure are less well understood. We previously demonstrated that IFN-αβγR-/- mice are exquisitely susceptible to liver infection following corneal infection with HSV-1. In this study, we used bone marrow chimeras of IFN-αβγR-/- (AG129) and wild-type (WT; 129SvEv) mice to probe the underlying IFN-dependent mechanisms that control HSV-1 pathogenesis. After infection, WT mice with either IFN-αβγR-/- or WT marrow exhibited comparable survival, while IFN-αβγR-/- mice with WT marrow had a significant survival advantage over their counterparts with IFN-αβγR-/- marrow. Furthermore, using bioluminescent imaging to maximize data acquisition, we showed that the transfer of IFN-competent hematopoietic cells controlled HSV-1 replication and damage in the livers of IFN-αβγR-/- mice. Consistent with this, the inability of IFN-αβγR-/- immune cells to control liver infection in IFN-αβγR-/- mice manifested as profoundly elevated aspartate transaminase (AST) and alanine transaminase (ALT) levels, indicative of severe liver damage. In contrast, IFN-αβγR-/-mice receiving WT marrow exhibited only modest elevations of AST and ALT levels. These studies indicate that IFN responsiveness of the immune system is a major determinant of viral tropism and damage during visceral HSV infections
Aromatic cyclotriphosphazenes
Four-Aminophenoxy cyclotriphosphazenes are reacted with maleic anhydride to produce maleamic acids which are converted to the maleimides. The maleimides are polymerized. By selection of starting materials (e.g., hexakis amino or trisaminophenoxy trisphenoxy cyclotrisphosphazenes), selection of molar porportions of reactants, use of mixtures of anhydrides and use of dianhydrides as bridging groups a variety of maleimides and polymers are produced. The polymers have high limiting oxygen indices, high char yields and other useful heat and fire resistant properties making them useful as, for example, impregnants of fabrics
Fire and heat resistant laminating resins based on maleimido substituted aromatic cyclotriphosphazene polymer
4-Aminophenoxy cyclotriphosphazenes are reacted with maleic anhydride to produce maleamic acids which are converted to the maleimides. The maleimides are polymerized. By selection of starting materials (e.g., hexakis amino or trisaminophenoxy trisphenoxy cyclotriphosphazenes), selection of molar proportions of reactants, use of mixtures of anhydrides and use of dianhydrides as bridging groups a variety of maleimides and polymers are produced. The polymers have high limiting oxygen indices, high char yields and other useful heat and fire resistant properties making them useful as, for example, impregnants of fabrics
Aminophenoxycyclotriphosphazene cured epoxy resins and the composites, laminates, adhesives and structures thereof
Aminophenoxy cyclotriphosphazenes such as hexakis (4-aminophenoxy) cyclotriphosphazene and tris (4-aminophenoxy)-tris phenoxy cyclotriphosphazene are used as curing agents for epoxy resins. These 1,2-epoxy resins are selected from di- or polyepoxide containing organic moieties of the formula (CH2-CHO-CH2) m-W-R-W- (CH2CH-CH2O)m where R is diphenyl dimethylmethane, diphenylmethane; W is a nitrogen or oxygen atom; and m is 1 when W is oxygen and 2 when W is nitrogen. The resins are cured thermally in stages at between about 110 to 135 C for between about 1 and 10 min, then at between about 175 to 185 C for between 0.5 to 10 hr and post cured at between about 215 and 235 C for between 0.1 and 2 hr. These resins are useful for making fire resistant elevated temperature stable composites, laminates, molded parts, and adhesives and structures, usually for aircraft secondary structures and for spacecraft construction
Process for preparing phthalocyanine polymer from imide containing bisphthalonitrile
Imide-linked bisphthalonitrile compounds are prepared by combining a dicyano aromatic diamine and an organic dianhydride to produce an amic acid linked bisphthalonitrile compound. The amic acid linked bisphthalonitrile compound is dehydrocyclized to produce the imide-linked bisphthalonitrile compounds. The imide-linked bisphthalonitrile compounds may be polymerized to produce a phythalocyanine polymer by heating the imide-linked bisphthalonitrile compound, either alone or in the presence of a metal powder or a metal salt. These compounds are useful in the coating, laminating and molding arts. The polymers are useful in composite matrix resins where increased fire resistance, toughness and resistance to moisture are required, particularly as secondary structures in aircraft and spacecraft
Kathryns Wheel: A spectacular galaxy collision discovered in the Galactic neighbourhood
We report the discovery of the closest collisional ring galaxy to the Milky
Way. Such rare systems occur due to "bulls-eye" encounters between two
reasonably matched galaxies. The recessional velocity of about 840 km/s is low
enough that it was detected in the AAO/UKST Survey for Galactic H
emission. The distance is only 10.0 Mpc and the main galaxy shows a full ring
of star forming knots, 6.1 kpc in diameter surrounding a quiescent disk. The
smaller assumed "bullet" galaxy also shows vigorous star formation. The
spectacular nature of the object had been overlooked because of its location in
the Galactic plane and proximity to a bright star and even though it is the
60 brightest galaxy in the HI Parkes All Sky Survey (HIPASS) HI
survey.
The overall system has a physical size of 15 kpc, a total mass of
M (stars + HI), a metallicity of
[O/H], and a star formation rate of 0.2-0.5 M\,yr,
making it a Magellanic-type system. Collisional ring galaxies therefore extend
to much lower galaxy masses than commonly assumed. We derive a space density
for such systems of , an order of magnitude
higher than previously estimated. This suggests Kathryn's Wheel is the nearest
such system. We present discovery images, CTIO 4-m telescope narrow-band
follow-up images and spectroscopy for selected emission components. Given its
proximity and modest extinction along the line of sight, this spectacular
system provides an ideal target for future high spatial resolution studies of
such systems and for direct detection of its stellar populations.Comment: 18 pages, 12 figures, accepted for publication in MNRA
The dynamical evolution of star-forming regions measured with INDICATE
Observations of star-forming regions provide snapshots in time of the star
formation process, and can be compared with simulation data to constrain the
initial conditions of star formation. In order to make robust inferences,
different metrics must be used to quantify the spatial and kinematic
distributions of stars. In this paper, we assess the suitability of the
INDICATE (INdex to Define Inherent Clustering And TEndencies) method as a
diagnostic to infer the initial conditions of star-forming regions that
subsequently undergo dynamical evolution. We use INDICATE to measure the degree
of clustering in N-body simulations of the evolution of star-forming regions
with different initial conditions. We find that the clustering of individual
stars, as measured by INDICATE, becomes significantly higher in simulations
with higher initial stellar densities, and is higher in subvirial star-forming
regions where significant amounts of dynamical mixing has occurred. We then
combine INDICATE with other methods that measure the mass segregation, relative
stellar surface density ratio and the morphology (Q-parameter) of star-forming
regions, and show that the diagnostic capability of INDICATE increases when
combined with these other metrics.Comment: 17 pages (including figures), 12 Figures. Accepted for publication in
MNRA
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Health Researchers' Use of Social Media: Scoping Review.
BackgroundHealth researchers are increasingly using social media in a professional capacity, and the applications of social media for health researchers are vast. However, there is currently no published evidence synthesis of the ways in which health researchers use social media professionally, and uncertainty remains as to how best to harness its potential.ObjectiveThis scoping review aimed to explore how social media is used by health researchers professionally, as reported in the literature.MethodsThe scoping review methodology guided by Arksey and O'Malley and Levac et al was used. Comprehensive searches based on the concepts of health research and social media were conducted in MEDLINE, EMBASE, CINAHL, PsycINFO, ERIC, and Web of Science databases, with no limitations applied. Articles were screened at the title and abstract level and at full text by two reviewers. One reviewer extracted data that were analyzed descriptively to map the available evidence.ResultsA total of 8359 articles were screened at the title and abstract level, of which 719 were also assessed at full text for eligibility. The 414 articles identified for inclusion were published in 278 different journals. Studies originated from 31 different countries, with the most prevalent being the United States (52.7% [218/414]). The health discipline of the first authors varied, with medicine (33.3% [138/414]) being the most common. A third of the articles covered health generally, with 61 health-specific topics. Papers used a range of social media platforms (mean 1.33 [SD 0.7]). A quarter of the articles screened reported on social media use for participant recruitment (25.1% [104/414]), followed by practical ways to use social media (15.5% [64/414]), and use of social media for content analysis research (13.3% [55/414]). Articles were categorized as celebratory (ie, opportunities for engagement, 72.2% [299/414]), contingent (ie, opportunities and possible limitations, 22.7% [94/414]) and concerned (ie, potentially harmful, 5.1% [21/414]).ConclusionsHealth researchers are increasingly publishing on their use of social media for a range of professional purposes. Although most of the sentiment around the use of social media in health research was celebratory, the uses of social media varied widely. Future research is needed to support health researchers to optimize their social media use
Awaking the vacuum in relativistic stars
Void of any inherent structure in classical physics, the vacuum has revealed
to be incredibly crowded with all sorts of processes in relativistic quantum
physics. Yet, its direct effects are usually so subtle that its structure
remains almost as evasive as in classical physics. Here, in contrast, we report
on the discovery of a novel effect according to which the vacuum is compelled
to play an unexpected central role in an astrophysical context. We show that
the formation of relativistic stars may lead the vacuum energy density of a
quantum field to an exponential growth. The vacuum-driven evolution which would
then follow may lead to unexpected implications for astrophysics, while the
observation of stable neutron-star configurations may teach us much on the
field content of our Universe.Comment: To appear in Phys. Rev. Let
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Wnt5a induces ROR1 to recruit cortactin to promote breast-cancer migration and metastasis.
ROR1 is a conserved oncoembryonic surface protein expressed in breast cancer. Here we report that ROR1 associates with cortactin in primary breast-cancer cells or in MCF7 transfected to express ROR1. Wnt5a also induced ROR1-dependent tyrosine phosphorylation of cortactin (Y421), which recruited ARHGEF1 to activate RhoA and promote breast-cancer-cell migration; such effects could be inhibited by cirmtuzumab, a humanized mAb specific for ROR1. Furthermore, treatment of mice bearing breast-cancer xenograft with cirmtuzumab inhibited cortactin phosphorylation in vivo and impaired metastatic development. We established that the proline at 841 of ROR1 was required for it to recruit cortactin and ARHGEF1, activate RhoA, and enhance breast-cancer-cell migration in vitro or development of metastases in vivo. Collectively, these studies demonstrate that the interaction of ROR1 with cortactin plays an important role in breast-cancer-cell migration and metastasis
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