1,555 research outputs found
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Efficacy of Multi-Modal Migraine Prophylaxis Therapy on Hyperacusis Patients.
ObjectivesTo evaluate the efficacy of a multi-modal migraine prophylaxis therapy for patients with hyperacusis.MethodsIn a prospective cohort, patients with hyperacusis were treated with a multi-modal step-wise migraine prophylactic regimen (nortriptyline, verapamil, topiramate, or a combination thereof) as well as lifestyle and dietary modifications. Pre- and post-treatment average loudness discomfort level (LDL), hyperacusis discomfort level measured by a visual analogue scale (VAS), and scores on the modified Khalfa questionnaire for severity of hyperacusis were compared.ResultsTwenty-two of the 25 patients (88%) reported subjective resolution of their symptoms following treatment. Post-treatment audiograms showed significant improvement in average LDL from 81.3 ± 3.2 dB to 86.4 ± 2.6 dB (P < .001), indicating increased sound tolerability. The VAS discomfort level also showed significant improvement from a pre-treatment average of 7.7 ± 1.1 to 3.7 ± 1.6 post-treatment (P < .001). There was also significant improvement in the average total score on modified Khalfa questionnaire (32.2 ± 3.6 vs 22.0 ± 5.7, P < .001).ConclusionsThe majority of patients with hyperacusis demonstrated symptomatic improvement from migraine prophylaxis therapy, as indicated by self-reported and audiometric measures. Our findings indicate that, for some patients, hyperacusis may share a pathophysiologic basis with migraine disorder and may be successfully managed with multimodal migraine prophylaxis therapy
Doctor of Education Newsletter 2020
WSU Doctor of Education Cohort 2020
This newsletter was created by the second Education Doctorate graduate student cohort 2020.https://openriver.winona.edu/educationeddnewsletters/1001/thumbnail.jp
The powers in PowerPoint: Embedded authorities, documentary tastes, and institutional (second) orders in corporate Korea
Microsoft PowerPoint is both the bane and banality of contemporary South Korean office work. Corporate workers spend countless hours refining and crafting plans, proposals, and reports in PowerPoint that often lead to conflicts with coworkers and overtime work. This article theorizes the excessive attention to documents in modern office contexts. Where scholars have been under the impression that institutional documents align with institutional purposes, I describe a context in which making documents for individual purposes and making them for work exist under a basic tension. Based on fieldwork in corporate Korea between 2013 and 2015, I describe how Korean office workers calibrate documents to the tastes of superiors who populate the managerial chain. These practices leave little trace of real "work" on paper, but they are productive for navigating complex internal labor markets and demonstrating a higher order value of attention toward others. These findings suggest that institutional and individual authorities are not competing projects inside organizations but become entangled in increasingly complex participatory encounters, even as they are channeled through a seemingly simple software like PowerPoint. [documents, expertise, authority, technology, South Korea
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A high-resolution map of human evolutionary constraint using 29 mammals.
The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5% of the human genome has undergone purifying selection, and locate constrained elements covering âŒ4.2% of the genome. We use evolutionary signatures and comparisons with experimental data sets to suggest candidate functions for âŒ60% of constrained bases. These elements reveal a small number of new coding exons, candidate stop codon readthrough events and over 10,000 regions of overlapping synonymous constraint within protein-coding exons. We find 220 candidate RNA structural families, and nearly a million elements overlapping potential promoter, enhancer and insulator regions. We report specific amino acid residues that have undergone positive selection, 280,000 non-coding elements exapted from mobile elements and more than 1,000 primate- and human-accelerated elements. Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease
Comparison against 186 canid whole genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor.
Canine transmissible venereal tumor (CTVT) is a parasitic cancer clone that has propagated for thousands of years via sexual transfer of malignant cells. Little is understood about the mechanisms that converted an ancient tumor into the world's oldest known continuously propagating somatic cell lineage. We created the largest existing catalog of canine genome-wide variation and compared it against two CTVT genome sequences, thereby separating alleles derived from the founder's genome from somatic drivers of clonal transmissibility. We show that CTVT has undergone continuous adaptation to its transmissible allograft niche, with overlapping mutations at every step of immunosurveillance, particularly self-antigen presentation and apoptosis. We also identified chronologically early somatic mutations in oncogenesis- and immune-related genes that may represent key initiators of clonal transmissibility. Thus, we provide the first insights into the specific genomic aberrations that underlie CTVT's dogged perseverance in canids around the world
Tumor Bed Delineation for Partial Breast and Breast Boost Radiotherapy Planned in the Prone Position: What Does MRI Add to X-ray CT Localization of Titanium Clips Placed in the Excision Cavity Wall?
PaLM: Scaling Language Modeling with Pathways
Large language models have been shown to achieve remarkable performance
across a variety of natural language tasks using few-shot learning, which
drastically reduces the number of task-specific training examples needed to
adapt the model to a particular application. To further our understanding of
the impact of scale on few-shot learning, we trained a 540-billion parameter,
densely activated, Transformer language model, which we call Pathways Language
Model PaLM. We trained PaLM on 6144 TPU v4 chips using Pathways, a new ML
system which enables highly efficient training across multiple TPU Pods. We
demonstrate continued benefits of scaling by achieving state-of-the-art
few-shot learning results on hundreds of language understanding and generation
benchmarks. On a number of these tasks, PaLM 540B achieves breakthrough
performance, outperforming the finetuned state-of-the-art on a suite of
multi-step reasoning tasks, and outperforming average human performance on the
recently released BIG-bench benchmark. A significant number of BIG-bench tasks
showed discontinuous improvements from model scale, meaning that performance
steeply increased as we scaled to our largest model. PaLM also has strong
capabilities in multilingual tasks and source code generation, which we
demonstrate on a wide array of benchmarks. We additionally provide a
comprehensive analysis on bias and toxicity, and study the extent of training
data memorization with respect to model scale. Finally, we discuss the ethical
considerations related to large language models and discuss potential
mitigation strategies
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