Ten Economic Facts About Crime and Incarceration in the United States

Crime and high rates of incarceration impose tremendous costs on society, with lasting negative effects on individuals, families, and communities. Rates of crime in the United States have been falling steadily, but still constitute a serious economic and social challenge. At the same time, the incarceration rate in the United States is so high -- more than 700 out of every 100,000 people are incarcerated -- that both crime scholars and policymakers alike question whether, for nonviolent criminals in particular, the social costs of incarceration exceed the social benefits

Altitude dependence of atmospheric temperature trends: Climate models versus observation

As a consequence of greenhouse forcing, all state of the art general circulation models predict a positive temperature trend that is greater for the troposphere than the surface. This predicted positive trend increases in value with altitude until it reaches a maximum ratio with respect to the surface of as much as 1.5 to 2.0 at about 200 to 400 hPa. However, the temperature trends from several independent observational data sets show decreasing as well as mostly negative values. This disparity indicates that the three models examined here fail to account for the effects of greenhouse forcings.Comment: 9 pages, 3 figure

Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression

The proximal tubule is a key regulator of kidney function and glucose metabolism. Diabetic kidney disease leads to proximal tubule injury and changes in chromatin accessibility that modify the activity of transcription factors involved in glucose metabolism and inflammation. Here we use single nucleus RNA and ATAC sequencing to show that diabetic kidney disease leads to reduced accessibility of glucocorticoid receptor binding sites and an injury-associated expression signature in the proximal tubule. We hypothesize that chromatin accessibility is regulated by genetic background and closely-intertwined with metabolic memory, which pre-programs the proximal tubule to respond differently to external stimuli. Glucocorticoid excess has long been known to increase risk for type 2 diabetes, which raises the possibility that glucocorticoid receptor inhibition may mitigate the adverse metabolic effects of diabetic kidney disease

Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types

Background: Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear

The discomforting rise of ' public geographies': a 'public' conversation.

In this innovative and provocative intervention, the authors explore the burgeoning ‘public turn’ visible across the social sciences to espouse the need to radically challenge and reshape dominant and orthodox visions of ‘the academy’, academic life, and the role and purpose of the academic

Verification of a Fully Implicit Particle-in-Cell Method for the v∥v_\parallel Formalism of Electromagnetic Gyrokinetics in the XGC Code

A fully implicit particle-in-cell method for handling the $v_\parallel$-formalism of electromagnetic gyrokinetics has been implemented in XGC. By choosing the $v_\parallel$-formalism, we avoid introducing the non-physical skin terms in Amp\`{e}re's law, which are responsible for the well-known ``cancellation problem" in the $p_\parallel$-formalism. The $v_\parallel$-formalism, however, is known to suffer from a numerical instability when explicit time integration schemes are used due to the appearance of a time derivative in the particle equations of motion from the inductive component of the electric field. Here, using the conventional $\delta f$ scheme, we demonstrate that our implicitly discretized algorithm can provide numerically stable simulation results with accurate dispersive properties. We verify the algorithm using a test case for shear Alfv\'{e}n wave propagation in addition to a case demonstrating the ITG-KBM transition. The ITG-KBM transition case is compared to results obtained from other $\delta f$ gyrokinetic codes/schemes, whose verification has already been archived in the literature

The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury

Background & Aims: In vertebrates, canonical Hedgehog (Hh) pathway activation requires Smoothened (SMO) translocation to the primary cilium (Pc), followed by a GLI-mediated transcriptional response. In addition, a similar gene regulation occurs in response to growth factors/cytokines, although independently of SMO signalling. The Hh pathway plays a critical role in liver fibrosis/regeneration; however, the mechanism of activation in chronic liver injury is poorly understood. This study aimed to characterise Hh pathway activation upon thioacetamide (TAA)- induced chronic liver injury in vivo by defining Hh-responsive cells, namely cells harbouring Pc and Pc-localised SMO. Methods: C57BL/6 mice (wild-type or Ptc1+/_) were TAA-treated. Liver injury and Hh ligand/pathway mRNA and protein expression were assessed in vivo. SMO/GLI manipulation and SMO dependent/ independent activation of GLI-mediated transcriptional response in Pc-positive (Pc+) cells were studied in vitro. Results: In vivo, Hh activation was progressively induced following TAA. At the epithelial-mesenchymal interface, injured hepatocytes produced Hh ligands. Progenitors, myofibroblasts, leukocytes and hepatocytes were GLI2+. Pc+ cells increased following TAA, but only EpCAM+/GLI2+ progenitors were Pc+/SMO+. In vitro, SMO knockdown/hGli3-R overexpression reduced proliferation/viability in Pc+ progenitors, whilst increased proliferation occurred with hGli1 overexpression. HGF induced GLI transcriptional activity independently of Pc/SMO. Ptc1+/_ mice exhibited increased progenitor, myofibroblast and fibrosis responses. Conclusions: In chronic liver injury, Pc+ progenitors receive Hh ligand signals and process it through Pc/SMO-dependent activation of GLI-mediated transcriptional response. Pc/SMO-independent GLI activation likely occurs in Pc_/GLI2+ cells. Increased fibrosis in Hh gain-of-function mice likely occurs by primary progenitor expansion/proliferation and secondary fibrotic myofibroblast expansion, in close contact with progenitors

Space User Visibility Benefits of the Multi-GNSS Space Service Volume: An Internationally-Coordinated, Global and Mission-Specific Analysis

The number and scope of Global Navigation Satellite System (GNSS)-based space applications has grown significantly since the first GNSS space receiver was flown in the early 1980's. The vast majority of GNSS space users operate in Low-Earth Orbit (LEO), where the use of GNSS receivers has become routine. However, the use of GNSS has expanded to other orbit regimes like Geostationary Orbits (GEO) and High Eccentric Orbits (HEO) but has been very limited due to the challenges involved. The major challenges for such types of orbits including much weaker signals, reduced geometric diversity, and limited signal availability. In any case, considering the recent development of multiple GNSS constellations and ongoing upgrades to existing constellations, GNSS signal availability will improve significantly. As a result, this expanded multi-GNSS signal capability will enable improved on-orbit navigation performance and will also allow the development of new mission concepts. High altitude space users will especially benefit from this evolution, which will provide GNSS signals to challenging regimes well beyond Low Earth Orbit. These benefits will only be realised, however, if additional signals are designed to be interoperable, are clearly documented and supported. In order to enhance the overall GNSS performance for spacecraft's in regimes from LEO, GEO to HEO and beyond, all Satellite Navigation constellation providers and regional augmentation system providers are working together through the United Nations International Committee on GNSS (ICG) forum to establish an interoperable GNSS Space Service Volume (SSV) for the benefit of all GNSS space users. This paper provides an overview of the technical work and in particular the simulations, performance analysis and discussions of the outcomes and results obtained by the UN ICG Working Group-B in the context of the GNSS Space Service Volume activities, which were supported by all GNSS service providers