Supersymmetric Higgs-portal and X-ray lines

We consider a Dirac singlet fermion as thermal dark matter for explaining the X-ray line in the context of a supersymmetric Higgs-portal model or a generalized Dirac NMSSM. The Dirac singlet fermion gets a mass splitting due to their Yukawa couplings to two Higgs doublets and their superpartners, Higgsinos, after electroweak symmetry breaking. We show that a correct relic density can be obtained from thermal freeze-out, due to the co-annihilation with Higgsinos for the same Yukawa couplings. We discuss the phenomenology of the Higgsinos in this model such as displaced vertices at the LHC.Comment: 15 pages, 4 figures, references adde

Cluster X-ray line at 3.5 keV3.5\,{\rm keV} from axion-like dark matter

The recently reported X-ray line signal at $E_\gamma \simeq 3.5\, {\rm keV}$ from a stacked spectrum of various galaxy clusters and the Andromeda galaxy may be originating from a decaying dark matter particle of the mass $2 E_\gamma$. A light axion-like scalar is suggested as a natural candidate for dark matter and its production mechanisms are closely examined. We show that the right amount of axion relic density with the preferred parameters, $m_a \simeq 7 \,{\rm keV}$ and $f_a \simeq 4\times 10^{14}\, {\rm GeV}$, can be naturally obtainable from the decay of inflaton. If the axions were produced from the saxion decay, it could not have constituted the total relic density due to the bound from structure formation. Nonetheless, the saxion decay is an interesting possibility, because the $3.5\, {\rm keV}$ line and dark radiation can be addressed simultaneously, being consistent with the Planck data. Small misalignment angles of the axion, ranging between $\theta_a\sim 10^{-4} -10^{-1}$ depending on the reheating temperature, can also be the source of axion production. The model with axion misalignment can satisfy the constraints for structure formation and iso-curvature perturbation.Comment: 14 pages, significant changes in the form, matched to the journal versio

BB-meson anomalies and Higgs physics in flavored U(1)′U(1)' model

We consider a simple extension of the Standard Model with flavor-dependent $U(1)'$, that has been proposed to explain some of $B$-meson anomalies recently reported at LHCb. The $U(1)'$ charge is chosen as a linear combination of anomaly-free $B_3-L_3$ and $L_\mu-L_\tau$. In this model, the flavor structure in the SM is restricted due to flavor-dependent $U(1)'$ charges, in particular, quark mixings are induced by a small vacuum expectation value of the extra Higgs doublet. As a result, it is natural to get sizable flavor-violating Yukawa couplings of heavy Higgs bosons involving the bottom quark. In this article, we focus on the phenomenology of the Higgs sector of the model including extra Higgs doublet and singlet scalars. We impose various bounds on the extended Higgs sector from Higgs and electroweak precision data, $B$-meson mixings and decays as well as unitarity and stability bounds, then discuss the productions and decays of heavy Higgs bosons at the LHC.Comment: 40 pages, 11 figures, 1 table; v2: references added; v3: accepted version for publication in EPJ

Diboson Excesses Demystified in Effective Field Theory Approach

We study the collider implication of a neutral resonance which decays to several diboson final states such as $W^+W^-$, $ZZ$, and $Z\gamma$ via a minimal set of effective operators. We consider both CP-even and CP-odd bosonic states with spin 0, 1, or 2. The production cross sections for the bosonic resonance states are obtained with the effective operators involving gluons (and quarks), and the branching fractions are obtained with the operators responsible for the interactions with electroweak gauge bosons. We demonstrate that each scenario allows for a broad parameter space which could accommodate the recently-reported intriguing excesses in the ATLAS diboson final states, and discuss how the CP states and spin information of the resonance can be extracted at the LHC run II.Comment: 22 pages, 6 figures, main text slightly modified with results unchange

Orai1 inhibitor STIM2?? regulates myogenesis by controlling SOCE dependent transcriptional factors

Store-operated Ca2+ entry (SOCE), the fundamental Ca2+ signaling mechanism in myogenesis, is mediated by stromal interaction molecule (STIM), which senses the depletion of endoplasmic reticulum Ca2+ stores and induces Ca2+ influx by activating Orai channels in the plasma membrane. Recently, STIM2??, an eight-residue-inserted splice variant of STIM2, was found to act as an inhibitor of SOCE. Although a previous study demonstrated an increase in STIM2?? splicing during in vitro differentiation of skeletal muscle, the underlying mechanism and detailed function of STIM2?? in myogenesis remain unclear. In this study, we investigated the function of STIM2?? in myogenesis using the C2C12 cell line with RNA interference-mediated knockdown and CRISPR-Cas-mediated knockout approaches. Deletion of STIM2?? delayed myogenic differentiation through the MEF2C and NFAT4 pathway in C2C12 cells. Further, loss of STIM2?? increased cell proliferation by altering Ca2+ homeostasis and inhibited cell cycle arrest mediated by the cyclin D1-CDK4 degradation pathway. Thus, this study identified a previously unknown function of STIM2?? in myogenesis and improves the understanding of how cells effectively regulate the development process via alternative splicing

Flavor and CP-violating Higgs sector in two Higgs doublet models with U(1)′U(1)'

We investigate the role of a local $U(1)'$ symmetry for the problem of CP violation in the effective theory for two Higgs doublet models and its microscopic counterparts. First, in two Higgs doublet models with $U(1)'$, we show that the higher-dimensional operators in the scalar potential violate the CP symmetry with an interplay with the mixing mass parameter, giving rise to small mixings between CP-even and CP-odd scalars. Motivated by the $B$-meson anomalies in recent years, we take the flavored $U(1)'$ to be a benchmark model for specifying the flavor structure. Then, we calculate the electric dipole moment of electron (eEDM) at two loops due to the CP-violating higher-dimensional operators and identify the correlation between the masses of heavy Higgs bosons and the cutoff scale from the bound on eEDM. We also comment on the possibility of making an independent test of the CP violation in the collider searches for heavy Higgs bosons. Finally, we show how the obtained eEDM results in the effective theory can be used to constrain microscopic models with an explicit CP violation in the partially decoupled or dark sectors.Comment: 37 pages, 5 figures, Journal versio

Malignancies in Korean Patients with Inflammatory Myopathy

The aim of this study was to assess the prevalence and the common type of malignancies in Korean patients with polymyositis (PM) and dermatomyositis (DM) and to evaluate the differences of clinical and laboratory findings between patients with malignancy and those without malignancy. Forty-one Korean patients, who were diagnosed as PM or DM, were enrolled in this study. They fulfilled the Bohan and Peter's criteria for a definite diagnosis of PM and DM. Patients with PM were 25 and those with DM were 16. Eleven out of 41 patients (26.8%) had malignancies. The malignancy was diagnosed simultaneously or later in 81.8% of patients with inflammatory myopathy (IM). The breast cancer was the most common malignancy. In this study, forty three years old as a screening age for malignancy had 88.9% sensitivity and 50.2% specificity. The serum levels of creatine kinase (CK) were significantly lower in patients with malignancy than those without malignancy