Suppressed Andreev Reflection at the Normal-Metal / Heavy-Fermion Superconductor CeCoIn5_5 Interface

Dynamic conductance spectra are taken from Au/CeCoIn$_5$ point contacts in the Sharvin limit along the (001) and (110) directions. Our conductance spectra, reproducibly obtained over wide ranges of temperature, constitute the cleanest data sets ever reported for HFSs. A signature for the emerging heavy-fermion liquid is evidenced by the development of the asymmetry in the background in the normal state. Below $T_c$, an enhancement of the sub-gap conductance arising from Andreev reflection is observed, with the magnitude of $\sim$ 13.3 % and $\sim$ 11.8 % for the (001) and the (110) point contacts, respectively, an order of magnitude smaller than those observed in conventional superconductors but consistent with those in other HFSs. Our zero-bias conductance data for the (001) point contacts are best fit with the extended BTK model using the d-wave order parameter. The fit to the full conductance curve of the (001) point contact indicates the strong coupling nature ($2\Delta/k_{B}T_c = 4.64$). However, our observed suppression of both the Andreev reflection signal and the energy gap indicates the failure of existing models. We provide possible directions for theoretical formulations of the electronic transport across an N/HFS interface. Several qualitative features observed in the (110) point contacts provide the first clear spectroscopic evidence for the $d_{x^2-y^2}$ symmetry.Comment: 13 pages, 7 figures, LaTeX, paper invited and submitted to SPIE Conference on Strongly Correlated Electron Materials: Physics and Nanoengineering, in San Diego, California, July 31 - August 4, 200

Andreev reflection spectroscopy of the heavy-fermion superconductor CeCoIn5_5 along three different crystallographic orientations

Andreev reflection spectroscopy has been performed on the heavy-fermion superconductor (HFS) CeCoIn$_5$ single crystals along three different crystallographic orientations, (001), (110), and (100), using Au tips as counter-electrodes. Dynamic conductance spectra are reproducible over wide temperature ranges and consistent with each other, ensuring the spectroscopic nature. Features common to all directions are: i) asymmetric behaviors of the background conductance, which we attribute to the emerging coherent heavy-fermion liquid; ii) energy scales (~1 meV) for conductance enhancement due to Andreev reflection; iii) magnitudes of enhanced zero-bias conductance (10 - 13 %). These values are an order of magnitude smaller than the predicted value by the Blonder-Tinkham-Klapwijk (BTK) theory, but comparable to those for other HFSs. Using the d-wave BTK model, we obtain an energy gap of ~ 460 ueV. However, it is found that extended BTK models considering the mismatch in Fermi surface parameters do not account for our data completely, which we attribute to the shift of spectral weight to low energy as well as to the suppressed Andreev reflection. A qualitative comparison of the conductance spectra with calculated curves shows a consistency with d$_{x^2-y^2}$-symmetry, providing the first spectroscopic evidence for the order parameter symmetry and resolving the controversy over the location of the line nodes.Comment: invited talk submitted to the 8th M2S conference to be held in Dresden Germany, July 9-14, 2006, 4 pages, 3 figure

Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes.

Glaucoma is characterized by a progressive loss of retinal ganglion cells and their axons, but the underlying biological basis for the accompanying neurodegeneration is not known. Accumulating evidence indicates that structural and functional abnormalities of astrocytes within the optic nerve head (ONH) have a role. However, whether the activation of cyclic adenosine 3',5'-monophosphate (cAMP) signaling pathway is associated with astrocyte dysfunction in the ONH remains unknown. We report here that the cAMP/protein kinase A (PKA) pathway is critical to ONH astrocyte dysfunction, leading to caspase-3 activation and cell death via the AKT/Bim/Bax signaling pathway. Furthermore, elevated intracellular cAMP exacerbates vulnerability to oxidative stress in ONH astrocytes, and this may contribute to axonal damage in glaucomatous neurodegeneration. Inhibition of intracellular cAMP/PKA signaling activation protects ONH astrocytes by increasing AKT phosphorylation against oxidative stress. These results strongly indicate that activation of cAMP/PKA pathway has an important role in astrocyte dysfunction, and suggest that modulating cAMP/PKA pathway has therapeutic potential for glaucomatous ONH degeneration

Limits of Binaries That Can Be Characterized by Gravitational Microlensing

Due to the high efficiency of planet detections, current microlensing planet searches focus on high-magnification events. High-magnification events are sensitive to remote binary companions as well and thus a sample of wide-separation binaries are expected to be collected as a byproduct. In this paper, we show that characterizing binaries for a portion of this sample will be difficult due to the degeneracy of the binary-lensing parameters. This degeneracy arises because the perturbation induced by the binary companion is well approximated by the Chang-Refsdal lensing for binaries with separations greater than a certain limit. For binaries composed of equal mass lenses, we find that the lens binarity can be noticed up to the separations of $\sim 60$ times of the Einstein radius corresponding to the mass of each lens. Among these binaries, however, we find that the lensing parameters can be determined only for a portion of binaries with separations less than $\sim 20$ times of the Einstein radius.Comment: 5 pages, 3 figures, 1 tabl

Efficacy and safety of primary posterior capsulotomy during phaco-vitrectomy for epiretinal membrane

Abstract Purpose To evaluate the necessity and safety of primary posterior capsulotomy during phaco-vitrectomy for idiopathic epiretinal membrane (ERM). Setting Seoul National University Bundang Hospital, Seongnam, Korea. Design Retrospective consecutive cohort analysis. Methods This study enrolled 219 patients (228 eyes) who underwent combined 25-gauge phaco-vitrectomy for idiopathic ERM and cataract, divided into capsulotomy (−) group (152 eyes, 144 patients) and capsulotomy (+) group (76 eyes, 75 patients). The main outcomes were rate of posterior capsular opacity (PCO) occurrence and postoperative complications. Ophthalmic examinations were performed at baseline, 1, 3, 6, and 12 months postoperatively. Results PCO only occurred in capsulotomy (−) group (20 eyes, 13.2%), with mean onset of 10.59 months. Visually-significant PCO that needed Nd:YAG posterior capsulotomy was present in 9 eyes (45.0% of PCO eyes). The rate of cystoid macular edema (CME) was higher in capsulotomy (+) group (6.6% vs. 15.8%, p= 0.026) with longer duration (1.50 vs. 3.36 months, p= 0.019). Female sex and posterior capsulotomy were significant risk factors for CME occurrence (p< 0.05). Conclusion Primary posterior capsulotomy during phaco-vitrectomy for idiopathic ERM obviated the need for Nd:YAG posterior capsulotomy, but visually-significant PCO that needed Nd:YAG laser was not common. Considering the low rate of visually-significant PCO and high rate of postoperative CME, routine posterior capsulotomy during phaco-vitrectomy may not be necessary for preventing PCO in ERM

Divided disk cache and SSD FTL for improving performance in storage

Although there are many efficient techniques to minimize the speed gap between processor and the memory, it remains a bottleneck for various commercial implementations. Since secondary memory technologies are much slower than main memory, it is challenging to match memory speed to the processor. Usually, hard disk drives include semiconductor caches to improve their performance. A hit in the disk cache eliminates the mechanical seek time and rotational latency. To further improve performance a divided disk cache, subdivided between metadata and data, has been proposed previously. We propose a new algorithm to apply the SSD that is flash memory-based solid state drive by applying FTL. First, this paper evaluates the performance of such a disk cache via simulations using DiskSim. Then, we perform an experiment to evaluate the performance of the proposed algorithm.clos