Spectral Decomposition of Missing Transverse Energy at Hadron Colliders

We propose a spectral decomposition to systematically extract information of dark matter at hadron colliders. The differential cross section of events with missing transverse energy (MET) can be expressed by a linear combination of basis functions. In the case of $s$-channel mediator models for dark matter particle production, basis functions are identified with the differential cross sections of sub-processes of virtual mediator and visible particle production while the coefficients of basis functions correspond to dark matter invariant mass distribution in the manner of the K\"all\'en-Lehmann spectral decomposition. For a given MET data set and mediator model, we show that one can differentiate a certain dark matter-mediator interaction from another through spectral decomposition.Comment: 6+4 pages, 6 figures, PRL versio

Conditions for Generic Initial Ideals to be Almost Reverse Lexicographic

Let $I$ be a homogeneous Artinian ideal in a polynomial ring $R=k[x_1,...,x_n]$ over a field $k$ of characteristic 0. We study an equivalent condition for the generic initial ideal \gin(I) with respect to reverse lexicographic order to be almost reverse lexicographic. As a result, we show that Moreno-Socias conjecture implies Fr\"{o}berg conjecture. And for the case \Codim I \le 3, we show that $R/I$ has the strong Lefschetz property if and only if \gin(I) is almost reverse lexicographic. Finally for a monomial complete intersection Artinian ideal $I=(x_1^{d_1},...,x_n^{d_n})$, we prove that \gin(I) is almost reverse lexicographic if $d_i > \sum_{j=1}^{i-1} d_j - i + 1$ for each $i \ge 4$. Using this, we give a positive partial answer to Moreno-Socias conjecture, and to Fr\"{o}berg conjecture.Comment: 10 page

STUDIES ON AZA-CYCLOADDITION:PART 1. INTRAMOLECULAR KETENE-IMINE CYCLOADDITIONPART 2. IMINIUM ION-MEDIATED [4+2] CYCLOADDITION

Part 1. Intramolecular Ketene-Imine CycloadditionThe ketene-imine cycloaddition reactions, developed previously by the Nelson group, have beenextended to the intramolecular cycloaddition of the ketene-imine cycloaddition. Initial resultsshowed that the intramolecular cycloaddition exhibited excellent enantioselectivity, but it wassuffered from poor diastereoselectivity. Later, it was shown that proper functionality on thetether of the substrate could improve diastereoselectivity.Part 2. Iminium Ion-Mediated [4+2] CycloadditionThe N-alkenyl iminium ion cycloaddition reaction (AIC reaction), developed previously by theNelson group, was further investigated for the more detailed understaniding. As a result, tworeaction pathways (Diels-Alder pathway and oxo-Diels-Alder pathway) of the AIC reaction werefound when carbamate-protected N-alkenyl iminium ion was employed as a 4Ĉ-electroncomponent. Based on this observation, efficient methods to turn off either one of the tworeaction pathways were proposed

Decreased Interleukin-4 Release from the Neurons of the Locus Coeruleus in Response to Immobilization Stress

It has been demonstrated that immobilization (IMO) stress affects neuroimmune systems followed by alterations of physiology and behavior. Interleukin-4 (IL-4), an anti-inflammatory cytokine, is known to regulate inflammation caused by immune challenge but the effect of IMO on modulation of IL-4 expression in the brain has not been assessed yet. Here, it was demonstrated that IL-4 was produced by noradrenergic neurons in the locus coeruleus (LC) of the brain and release of IL-4 was reduced in response to IMO. It was observed that IMO groups were more anxious than nontreated groups. Acute IMO (2 h/day, once) stimulated secretion of plasma corticosterone and tyrosine hydroxylase (TH) in the LC whereas these increments were diminished in exposure to chronic stress (2 h/day, 21 consecutive days). Glucocorticoid receptor (GR), TH, and IL-4-expressing cells were localized in identical neurons of the LC, indicating that hypothalamic-pituitary-adrenal- (HPA-) axis and sympathetic-adrenal-medullary- (SAM-) axis might be involved in IL-4 secretion in the stress response. Accordingly, it was concluded that stress-induced decline of IL-4 concentration from LC neurons may be related to anxiety-like behavior and an inverse relationship exists between IL-4 secretion and HPA/SAM-axes activation

Plug-in, Trainable Gate for Streamlining Arbitrary Neural Networks

Architecture optimization, which is a technique for finding an efficient neural network that meets certain requirements, generally reduces to a set of multiple-choice selection problems among alternative sub-structures or parameters. The discrete nature of the selection problem, however, makes this optimization difficult. To tackle this problem we introduce a novel concept of a trainable gate function. The trainable gate function, which confers a differentiable property to discretevalued variables, allows us to directly optimize loss functions that include non-differentiable discrete values such as 0-1 selection. The proposed trainable gate can be applied to pruning. Pruning can be carried out simply by appending the proposed trainable gate functions to each intermediate output tensor followed by fine-tuning the overall model, using any gradient-based training methods. So the proposed method can jointly optimize the selection of the pruned channels while fine-tuning the weights of the pruned model at the same time. Our experimental results demonstrate that the proposed method efficiently optimizes arbitrary neural networks in various tasks such as image classification, style transfer, optical flow estimation, and neural machine translation.Comment: Accepted to AAAI 2020 (Poster

Macroeconomic and Bank-Specific Determinants of the U.S. Non-Performing Loans: Before and During the Recent Crisis

Both macroeconomic and bank-specific factors are correlated to the occurrence of Non-Performing Loans (NPL). We use a sample of U.S. banks over two distinct time periods to provide empirical evidence of various key macroeconomic and bankspecific determinants’ effects on NPLs

IL-4 Inhibits IL-1β-Induced Depressive-Like Behavior and Central Neurotransmitter Alterations

It has been known that activation of the central innate immune system or exposure to stress can disrupt balance of anti-/proinflammatory cytokines. The aim of the present study was to investigate the role of pro- and anti-inflammatory cytokines in the modulation of depressive-like behaviors, the hormonal and neurotransmitter systems in rats. We investigated whether centrally administered IL-1β is associated with activation of CNS inflammatory pathways and behavioral changes and whether treatment with IL-4 could modulate IL-1β-induced depressive-like behaviors and central neurotransmitter systems. Infusion of IL-4 significantly decreased IL-1β-induced anhedonic responses and increased social exploration and total activity. Treatment with IL-4 markedly blocked IL-1β-induced increase in PGE2 and CORT levels. Also, IL-4 reduced IL-1β-induced 5-HT levels by inhibiting tryptophan hydroxylase (TPH) mRNA and activating serotonin transporter (SERT) in the hippocampus, and levels of NE were increased by activating tyrosine hydroxylase (TH) mRNA expression. These results demonstrate that IL-4 may locally contribute to the regulation of noradrenergic and serotonergic neurotransmission and may inhibit IL-1β-induced behavioral and immunological changes. The present results suggest that IL-4 modulates IL-1β-induced depressive behavior by inhibiting IL-1β-induced central glial activation and neurotransmitter alterations. IL-4 reduced central and systemic mediatory inflammatory activation, as well as reversing the IL-1β-induced alterations in neurotransmitter levels. The present findings contribute a biochemical pathway regulated by IL-4 that may have therapeutic utility for treatment of IL-1β-induced depressive behavior and neuroinflammation which warrants further study

Pain Management of Herpes Zoster

Herpes zoster (HZ) is a disease triggered by the reactivation of latent varicella zoster virus (VZV) in spinal or cranial sensory ganglia, and is characterized by a painful vesicular eruption in the affected dermatome. Postherpetic neuralgia (PHN) is a chronic, neuropathic pain that can persist long beyond resolution of visible cutaneous manifestations which is often resistant to current analgesic treatments. The lifetime prevalence of herpes zoster is approximately 20–30% and about 9–34% of these patients develop PHN depending on its definition. Clinical experience has shown that PHN often develops in cases of inadequate initial pain management resulting in increased pain intensity. This review provides an overview of the treatment options for HZ and PHN, focusing on the therapeutic modalities of pain management. The primary objectives of management of HZ are to inhibit viral replication, relieve pain, and prevent associated complications, such as PHN. General treatments for acute HZ are combination of antiviral therapy with a short course of corticosteroids at the onset of the disease in conjunction with an effective control of acute pain, including nonsteroidal anti-inflammatory drugs, acetaminophen, opioids, and anticonvulsants such as gabapentin or pregabalin. Treatment of PHN is often resistant to the current pharmacologic methods. Therefore, a multimodal analgesic treatment regimen including topical lidocaine and capsaicin, systemic therapies, and the interventional treatments is necessary to alleviate pain and its effect on quality of life. As the incidence of HZ increases with age, the number of patients with HZ and PHN may increase in the future considering the gradual aging of the general population. Appropriate management of HZ can reduce the duration and intensity of pain from HZ, and prevent the development of PHN. In addition, prophylactic zoster vaccination can prevent or reduce the incidence of HZ and PHN. Further efforts are needed to minimize pain of the patients suffering from HZ and PHN as it affects the quality of life in the aspect of both physical and psychological impairments