Numerical Analysis of Saturated Sand Under Dynamic Loads

In this study, the behavior of reclaimed soils including the effects of excess pore water pressure and the loss of strength under dynamic loads or earthquakes are investigated and simulated. The constitutive model based on the disturbed state concept (DSC) is introduced and DSC-DYN2D program is utilized in a numerical analysis. In the laboratory test, quasi-static and cyclic triaxial tests were carried out to determine parameters for the numerical analysis. Field tests were executed in Inchon International Airport with a 10 tons hydraulic hammer. In the field test, the data of dynamic loads and excess pore water pressure were measured using a 3-D geophone and a pressure transducer respectively, The data of field tests showed the accumulation of excess pore water pressure when rapid dynamic loads were applied. Especially, a back-prediction program based on DSC model is developed and verified its accuracy using various parameters from the cyclic triaxial test. As the results of numerical simulation, the predicted trends for excess pore water pressure compare well with the observed data. Based on the result of this research, it is found that the numerical analysis based on the DSC model is compatible to predict the softening behavior of saturated reclaimed soils under dynamic loads

Specific Intracellular Uptake of Herceptin-Conjugated CdSe/ZnS Quantum Dots into Breast Cancer Cells

Herceptin, a typical monoclonal antibody, was immobilized on the surface of CdSe/ZnS core-shell quantum dots (QDs) to enhance their specific interactions with breast cancer cells (SK-BR3). the mean size of the core-shell quantum dots (28 nm), as determined by dynamic light scattering, increased to 86 nm after herceptin immobilization. the in vitro cell culture experiment showed that the keratin forming cancer cells (KB) proliferated well in the presence of herceptin-conjugated QDs (QD-Her, 5 nmol/mL), whereas most of the breast cancer cells (SK-BR3) had died. to clarify the mechanism of cell death, the interaction of SK-BR3 cells with QD-Her was examined by confocal laser scanning microscopy. as a result, the QD-Her bound specifically to the membrane of SK-BR3, which became almost saturated after 6 hours incubation. This suggests that the growth signal of breast cancer cells is inhibited completely by the specific binding of herceptin to the Her-2 receptor of SK-BR3 membrane, resulting in cell death

Disturbed state modeling for dynamic and liquefaction analysis

Although a number of models have been proposed to characterize behavior of geological materials including elastic, plastic, and cyclic loading responses, few constitutive models have been developed for the behavior of fully saturated sands and interfaces including liquefaction under dynamic loading. Such realistic constitutive models play an important role in analyzing and predicting the response and design of soil-structure interaction systems. Also, in the engineering view of the complexity of the material behavior, it becomes necessary to develop and use computer procedure (finite element method) for the analysis and prediction of behavior of geotechnical problems. A general concept, called the disturbed state concept (DSC), that can characterize behavior of geological material is developed in this dissertation for the behavior of saturated sands and sand-steel interfaces. The DSC model is an unified approach and allows hierarchical use of the model for factors such as elastic and plastic strains, damage, and softening and stiffening. The model parameters for a saturated sand and a sand-steel interface are evaluated using data from comprehensive laboratory tests; truly triaxial test device for the saturated sand and cyclic multi-degree-of-freedom device (CYMDOF-P) for the interface. The laboratory test results are also used for the verification of DSC model. In general, the model predictions were found to provide satisfactory correlation with the test results. The DSC model with the foregoing parameters is implemented in a nonlinear dynamic finite element program(DSC-DYN2D). It is used to solve two boundary value problems-an axially loaded pile and a shaking table test-involving the interface behavior for pile and the liquefaction for shake table. A new and highly efficient method is used to determine the liquefaction in saturated materials. This method is based on the changing microstructure of the material and allows identification of liquefaction based on the critical disturbance, Dc which is the point where the curvature of the disturbance function is the minimum. Based on the results of this research, it can be stated that the DSC model is capable of characterizing the cyclic behavior of saturated sands and interfaces and the liquefaction instability under dynamic and earthquake loading

Seismic Response of Container Crane under Near-Field and Far-Field Ground Motions

In this study, the seismic response of a container crane under near-field and far-field ground motions was investigated using a shaking table test on a 1/20 scale crane. The 1/20 scale crane was designed and fabricated based on the similitude laws, in which three independent quantities: geometric length, acceleration, and elastic modulus, were used to design the 1/20 scale crane. A series of shaking table tests were conducted at the Seismic Research and Test Center, Pusan National University, Yangsan Campus to evaluate the seismic response of the scale crane under near-field and far-field ground motions. The results show that the near-field ground motions can cause larger internal forces (that is, axial force and two bending moments) in the landside and seaside legs and larger portal drift than the far-field ground motions. The portal drift of the container crane subjected to the near-field ground motions was 43% higher than that of the container crane subjected to the far-field ground motions. Furthermore, when subjected to the near-field ground motion, the bending moment in the crane’s portal leg was 37% higher than the bending moment when the crane was subjected to the far-field ground motions

Sensitivity Analysis for Ship-to-Shore Container Crane Design

Ship-to-shore (STS) container cranes are important pieces of equipment in container terminals for container handling, so they need to be properly designed to avoid damage or collapse due to natural hazards (i.e., storms or earthquakes). However, the dynamic analyses necessary for this can be cost- and time-consuming because of the need to consider the time history of ground motions and several sources of uncertainty. Thus, sensitivity analysis on the input parameters to the responses of the structures is needed to categorize which sources of uncertainty are significant enough to be considered as random variables. In this study, an investigation is carried out into the sensitivity of some sources of uncertainty to the seismic response of a Korean container crane structure. The input random variables studied include ground motion intensity, ground motion profiles, mass, damping, and elastic modulus of steel. Nonlinear dynamic analyses are conducted using a set of 20 natural ground motions scaled to three ground motion intensity levels, in compliance with the Korean Design Standard. The method of deterministic sensitivity analysis using the so-called tornado diagram is applied for the evaluation of structural systems. For the studied type of Korean container crane, it can be stated that the intensity of ground motions (i.e., spectral acceleration) is the most significant input parameter on the response of the structure, as measured in terms of portal drift, vertical reaction of the crane’s legs, and total base shear. The next most significant influencing factors are the mass of the structure and the characteristics of every ground motion. Damping plays a relatively important role on the total base shear, while it shows almost no impact on the axial reaction of the crane’s legs. Of the three engineering design parameters (portal drift, vertical reaction, and total base shear), the elastic modulus exhibits a low effect, but it should be considered a source of uncertainty in seismic analysis

Association of Estimated Glomerular Filtration Rate with Risk of Head and Neck Cancer: A Nationwide Population-Based Study

In this study, through a cohort study of 10 million people, we investigated the association between estimated glomerular filtration rate (eGFR) and head and neck cancer (HNC) incidence. This is an observational cohort study using data from the national health claims database established by the Korean National Health Insurance Service (NHIS). We selected 9,598,085 participants older than 20 years who had undergone health checkups in 2009. A health checkup involves the history of any diseases, current health status, and results of several physical and blood exams including eGFR. We investigated the presence of HNC diagnosis in their national health insurance data from 2010 to 2018. Of the 9,598,085 participants, 10,732 had been newly diagnosed with HNC in the 9-year follow-up. In the multivariate Cox proportional hazard model, participants with elevated eGFR were associated with a risk of HNC incidence (HR = 1.129; 95% CI = 1.075–1.186 for eGFR = 90–104 mL/min/1.73 m2 and HR = 1.129; 95% CI = 1.076–1.194 for eGFR ≥ 105 mL/min/1.73 m2) compared with those with eGFR 60–89 mL/min/1.73 m2. Among HNC, the incidences of oral cavity, oropharyngeal, hypopharyngeal, and laryngeal cancers were significantly increased in the elevated eGFR group. According to the subgroup analysis, participants with eGFR ≥ 60 mL/min/1.73 m2 were correlated with risk of HNC incidence in middle age, non/mild drinker, low BMI, no diabetes, and no hypertension patients compared with those with eGFR 2. Elevated eGFR was associated with the risk of some type of HNC, even in individuals with adjusted hypertension and diabetes without chronic diseases. The results of this study have implications for etiological investigations and preventive strategies

Associations of Body Mass Index and Waist Circumference with the Risk of Head and Neck Cancer: A National Population-Based Study

Background: We investigated the association between BMI and HNC subtype incidence in a cohort study of ten million people, adjusting for the effect of smoking and drinking. We also investigated the relationship between waist circumference (WC) and HNC subtype. Methods: All data used in this study originated from the Korean National Health Insurance Service database. We analysed subjects who had undergone health check-ups in 2009 and monitored subjects until 2018 (n = 10,585,852). Finally, 9,598,085 subjects were included after exclusions. We collected variables that could affect the risk of HNC. Cox proportional hazards regression analysis was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: The overall incidence of HNC was higher in the low BMI category (BMI < 18.5 according to WHO recommendations for Asian people) (HR: 1.322; 95% CI: 1.195–1.464) compared with the normal BMI category. Among the HNC cases, the incidence rates of laryngeal (HR: 1.3; 95% CI: 1.085–1.558), oral cavity (HR: 1.277; 95% CI: 1.011–1.611), and oropharyngeal (HR: 1.584; 95% CI: 1.25–2.008) cancers were higher in the low BMI category compared with the normal BMI category. No significant association was detected between low BMI and sinus cancer, salivary gland cancer, or nasopharyngeal cancer. The low WC category (<80 cm in men and <75 cm in women) was related to a risk of hypopharyngeal (HR: 1.268; 95% CI: 1.061–1.514) and laryngeal (HR: 1.118; 95% CI: 1.007–1.241) cancers. The HR for occurrence of HNC was high in underweight participants according to smoking status (1.219 for never smoker vs. 1.448 for ever smoker, p for interaction = 0.0015) and drinking status (1.193 for never drinker vs. 1.448 for ever drinker, p for interaction = 0.0044). Conclusions: Low BMI was associated with the risk of some types of HNC. The results of this study could assist etiological investigations and prevention strategies

Sex Differences in the Prevalence of Head and Neck Cancers: A 10-Year Follow-Up Study of 10 Million Healthy People

Background: Descriptive epidemiologists have repeatedly reported that males are more susceptible to head and neck cancers. However, most published data are those of cross-sectional studies, and no population-based cohort study has yet been published. The aim of this study was to compare the prevalence of head and neck cancers in healthy males with females. Methods: A retrospective cohort study using the Korean National Health Insurance Service database on 9,598,085 individuals who underwent regular health checkups from 1 January to 31 December 2009. We sought head and neck cancers developed during the 10-year follow-up. Results: A total of 10,732 (incidence rate (IR) per 1000 person-years 0.25) individuals were newly diagnosed with head and neck cancer among the 9,598,085 individuals during the 10-year follow-up. The IR was 0.19 in males (8500 affected) and 0.06 in females (2232 affected). Notably, the male–female ratio increased with age below 70 years but decreased thereafter. The male–female difference was most apparent for laryngeal cancer; the male IR was 11-fold higher in the 40 s and 20-fold higher in the 60 s, followed by hypopharyngeal cancer (6.8- and 24.2-fold). Males smoked more and drank more alcohol than females (p < 0.0001 *, p < 0.0001 *). When never-smokers/-drinkers (only) were compared, males remained at a 2.9-fold higher risk of head and neck cancer than females. The hazard ratios for head and neck cancers in males tended to increase in the lower part of the upper aerodigestive tract: larynx (13.9) > hypopharynx (10.9) > oropharynx (4.4) > nasopharynx (2.9) > sinonasal region (1.8) > oral (1.6). Only the salivary gland cancer incidence did not differ between the sexes; the gland is not in the upper aerodigestive tract. Conclusion: Males are much more susceptible to head and neck cancers than females regardless of whether they drink alcohol or smoke tobacco. Sex differences in the incidence of head and neck cancer are most evident in the 60 s in the lower part of the upper aerodigestive tract, such as the larynx and hypopharynx