HYPOGLYCEMIC ACTIVITY OF A NOVEL POLYHERBAL FORMULATION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS: A THERAPEUTIC STUDY

Objective: The concept of the synergistic effect of poly-herbalism was as old as medicine history. Present novel polyherbal formulation (PHF) composed of five different herbs. The present investigation aimed to evaluate the synergistic therapeutic hypoglycemic potential of PHF against streptozotocin (STZ) (60 mg/kg b.w, ip)-induced diabetic rats. Methods: For this therapeutic study, the dose was framed orally once a day to the test objects after STZ dosing at 500 mg/kg/5 ml dosage levels for 21 days. The transformation of body weight and blood glucose level was examined, and the histopathological changes of beta cells of the pancreas, cellular architectures of liver and kidney were also perceived after scarification of the objects. Results: The outcomes were compared to that of glibenclamide (5 mg/kg) treated group. Declines of body weight and blood glucose levels were perceived in STZ-induced diabetic animals very significantly (p<0.01 or p<0.05). However, these diabetic changes were significantly (p<0.01 or p<0.05) decreased in PHF-dosing groups revealed more encouraging effects compared to that of glibenclamide. In the other hand, various liver function and enzymes test (creatinine, urea, total bilirubin, total albumin, alkaline phosphatase, gamma-glutamyl transferase, aspartate transaminases, and alanine transaminases) and lipid profile (total cholesterol, triglycerides, high-density lipoprotein cholesterol, total protein, low-density lipoprotein [LDL], and very LDL) studies strongly indicate the potential action of this novel formulation. Conclusions: It is deliberated that PHF has the favorable effect to normalize the blood glucose levels, and also rejuvenation and reproduction of beta cells lead a better futuristic ant diabetic therapy for diabetic management

WOUND HEALING ACTIVITY OF FRUITS OF ANAMIRTA COCCULUS LINN IN RATS

Objective: The fruits of Anamirta Cocculus Linn are used traditionally in India for the treatment of bronchitis, chronic skin diseases, foul ulcers, dermatophytosis, phthisis, fungal infections, vertigo and vitiated conditions of vata & kapha. The purpose of the present study was to evaluate the wound healing activity of the ethanolic extract of its fruit in excision wound model.Methods: Albino Wistar rats of either sex were divided into three groups, viz, wounded control, wounded rats administered standard drug Ciprofloxacin (2 %), and wounded rats administered A.C. 200 mg/kg, respectively. In excision wound model, wound contraction was studied.Results: Increased wound contraction was observed in the extract-treated group when compared to control. Wound healing activity was statistically significant (p < 0.05) & (p < 0.001) in animals treated with 200 mg/kg of the extract.Conclusion: The ethanolic extract of A. Cocculus possesses significant wound healing activity. Keywords: Anamirta Cocculus, Wound healing, Dermatophytosis, Wound model

Antidiabetic activity of compounds isolated from the roots of Premna latifolia Roxb

Purpose: To evaluate the hypoglycaemic activity of the ethanol extract, chloroform  fraction, and three compounds isolated from Premna latifolia.Methods: The ethanol extract, chloroform fraction, and compounds 1 – 3 (isolated from the chloroform fraction) of P. latifolia were characterised by nuclear magnetic resonance (1H NMR, 13C NMR and 2D NMR). In vitro activity was assessed by α-amylase and α-glucosidase inhibitory activity assays. In vivo antidiabetic activity was evaluated in a streptozotocin-nicotinamide-induced rat model of diabetes. Fasting blood glucose (FBG), glycosylated haemoglobin (HbA1C), serum creatinine, blood urea nitrogen (BUN), liver enzymes, and antioxidant enzymes were  determined. Liver and pancreas histopathology was assessed.Results: Compounds 2 and 3 exhibited significant hypoglycaemic activity by reducing elevated FBG and HbA1C (p ≤ 0.001) and also exerted positive effects on blood and liver enzyme profiles, which were largely altered in diabetic control group. These compounds also showed significant antioxidant activity, increasing catalase, superoxide dismutase, and glutathione reductase, while lowering malondialdehyde (p ≤ 0.001). The histopathology results for the rats that received these compounds suggested regeneration of pancreatic β-cells.Conclusion: Compounds 2 and 3 isolated from the dried roots of P. latifolia possess significant hypoglycaemic activity, reno- and hepatoprotective effects, and antioxidant activity. They show promise as potential treatments for patients with diabetes.Keywords: Antioxidant, Hypoglycaemic, Premna latifolia, Stigmanstan-3β-olyl n-octadec-9ʹ, 12ʹ- dienoate, n-Tetracosanol, n-Tridecanyl n-Tetracosanoat

A Comprehensive Ethno-Phyto-Pharmacological Review on Novel Indian Medicinal Plants Used In Polyherbal Formulations

Almost 15% out of the 20,000 medicinal plants in Indian sub continent has a tremendous potential and advantage in the emerging field of herbal medicines. Medicinal plants are the main sources of chemical substances with potential therapeutic effects. A lot of compounds were characterized from plants which are now using in the treatment of many diseases. Since ancient times, plants have been an exemplary source of medicine. Ayurveda and other Indian literature mentioned the use of plants in treatment of various human ailments. Medical plants play an important role in the management of different clinical problems especially in developing countries where resources are meager The present paper reviews the literature on recent ethno medicinal uses with pharmacological screeing of every plant part of different five medicinal plants, i.e Cassia Auriculata Linn, Cinnamomum tamala, Ficus benghalensis, Trichosynthes dioica and Mangifera indica and their phytochemical properties used for the treatment of various ailments in human civilization as well as used in folk medicine as a remedy. The name and parts of the plant studied, the spectrum of activity, and methods used are discussed in this review paper

A REVIEW OF COMPREHENSIVE STUDY ON MEDICINAL PLANTS OF POLYHERBAL FORMULATION – CHURNA

Ayurvedic medicines are the combinations of selected herbal drugs and are manufactured under different pharmaceutical processes to result in various dosage forms such as churnas, bhasmas, liquid, lehas, pill, tablet etc. Churna is defined as a fine powder of drug or drugs in ayurvedic system of medicine. The churna is free flowing and retains its potency for one year, if preserved in airtight containers.  Churna formulations are similar to powder formulations in allopathic system of medicine. In recent days churna is formulated into tablets in order to fix the dose easily. These forms of medicament are prescribed generally because of their particle size. Smaller the particle size greater is the absorption rate from g.i.t and hence the greater is bioavailability. Herbal medicine has been enjoying renaissance among the customers throughout the world. Ayurvedic principles show that everyone has a particular personality type as shown by the make up of their dos has, or inner life energies. Your prakriti is your make up when you were born, and vikruti is what they are now as a result of life's experiences and stresses and imbalances of other elemental influences. In order to correct these derangements, one can use churnas, or Ayurvedic spice powders that are made up of blends of spices. These churnas are made of fresh herbs that have medicinal properties, as well as the ability to neutralize the toxic effects caused by imbalances within the body. Ayurvedic churnas combine all six of the ayurvedic tastes: sweet, sour, salty, pungent, bitter, and astringent. They are created through the combination of a number of different fresh herbs, and can be added to almost any foodstuff. Not only do churnas improve the taste of the dish and add their own nutritional kick, they also bring out the medicinal qualities of the foods they are added to. Churna is an ayurvedic poly herbal formulation used for its anti-ulcer, anti-diabetic, wound-healing, antioxidant, immuno modulatory and rejuvenating purpose. In this review article  It includes five herbal drugs, ie; dried whole plant part of [1]Mimosa pudica (Family: Leguminosae), dried rind of Punica granatum( Family: Lythraceae) ,dried fruit of Emblica officinalis (familuy: Ephorbiaceae), dried seeds of  [2]Sesamum indicum ( family: Pedaliaceae), dried seeds of Cuminum cyminum( family: Apiaceae) in powder form .The present review encompasses all the important aspects of polyherbal formulation-churna of above mentioned four plants.Keywords: Choorna, Mimosa pudica, Punica granatum,  Emblica officinalis ,Sesamum indicum, Cuminum cyminu

A Comprehensive Ethno-Phyto-Pharmacological Review on Novel Indian Medicinal Plants Used In Polyherbal Formulations

Almost 15% out of the 20,000 medicinal plants in Indian sub continent has a tremendous potential and advantage in the emerging field of herbal medicines. Medicinal plants are the main sources of chemical substances with potential therapeutic effects. A lot of compounds were characterized from plants which are now using in the treatment of many diseases. Since ancient times, plants have been an exemplary source of medicine. Ayurveda and other Indian literature mentioned the use of plants in treatment of various human ailments. Medical plants play an important role in the management of different clinical problems especially in developing countries where resources are meager The present paper reviews the literature on recent ethno medicinal uses with pharmacological screeing of every plant part of different five medicinal plants, i.e Cassia Auriculata Linn, Cinnamomum tamala, Ficus benghalensis, Trichosynthes dioica and Mangifera indica and their phytochemical properties used for the treatment of various ailments in human civilization as well as used in folk medicine as a remedy. The name and parts of the plant studied, the spectrum of activity, and methods used are discussed in this review paper

<b>Safety evaluation of a polyherbal formulation, <i>Zuroor-E –Qula</i</b>

286-289Zuroor-e-Qula, a powdered polyherbal Unani formulation, known to possess anti-microbial and anti-inflammatory properties is recommended in cases of stomatitis and gastric ulceration. The freshly prepared formulation was evaluated for its mineral contents, microbial count, aflatoxins and pesticide residues. The results revealed that this formulation is free from such contaminants and its use is safe

Review on nutritional, medicinal and pharmacological properties of Papaya (<i>Carica</i><i> papaya </i>Linn.)

364-373Papaya (Carica papaya Linn.) is commonly known for its food and nutritional values throughout the world. The medicinal properties of papaya fruit and other parts of the plant are also well known in traditional system of medicine. Since, each part of papaya tree possesses economic value, it is grown on commercial scale. During the last few decades considerable progress has been achieved regarding the biological activity and medicinal application of papaya and now it is considered as valuable nutraceutical fruit plant. It can be chosen as a source of papain for the development of various industrial and pharmaceutical products for various diseases. In the present review nutritional value of the fruit and medicinal properties of its various parts have been discussed to provide collective information on this multipurpose commercial fruit crop