On phonetic convergence during conversational interaction,”

Following research that found imitation in single-word shadowing, this study examines the degree to which interacting talkers increase similarity in phonetic repertoire during conversational interaction. Between-talker repetitions of the same lexical items produced in a conversational task were examined for phonetic convergence by asking a separate set of listeners to detect similarity in pronunciation across items in a perceptual task. In general, a listener judged a repeated item spoken by one talker in the task to be more similar to a sample production spoken by the talker's partner than corresponding pre-and postinteraction utterances. Both the role of a participant in the task and the sex of the pair of talkers affected the degree of convergence. These results suggest that talkers in conversational settings are susceptible to phonetic convergence, which can mark nonlinguistic functions in social discourse and can form the basis for phenomena such as accent change and dialect formation

Inhibition of MMP-9-dependent degradation of gelatin, but not other MMP-9 substrates, by the MMP-9 hemopexin domain blades 1 and 4

11 p.-5 fig.-1 tab.Degradation and remodeling of the extracellular matrix by matrix metalloproteinases (MMPs) plays important roles in normal development, inflammation, and cancer. MMP-9 efficiently degrades the extracellular matrix component gelatin, and the hemopexin domain of MMP-9 (PEX9) inhibits this degradation. To study the molecular basis of this inhibition, we generated GST fusion proteins containing PEX9 or truncated forms corresponding to specific structural blades (B1-B4) of PEX9. GST-PEX9 inhibited MMP-9-driven gelatin proteolysis, measured by gelatin zymography, FITC-gelatin conversion, and DQ-gelatin degradation assays. However, GST-PEX9 did not prevent the degradation of other MMP-9 substrates, such as a fluorogenic peptide, αB crystalline, or nonmuscular actin. Therefore, PEX9 may inhibit gelatin degradation by shielding gelatin and specifically preventing its binding to MMP-9. Accordingly, GST-PEX9 also abolished the degradation of gelatin by MMP-2, confirming that PEX9 is not an MMP-9 antagonist. Moreover, GST-B4 and, to a lesser extent, GST-B1 also inhibited gelatin degradation by MMP-9, indicating that these regions are responsible for the inhibitory activity of PEX9. Accordingly, ELISAs demonstrated that GST-B4 and GST-B1 specifically bound to gelatin. Our results establish new functions of PEX9 attributed to blades B4 and B1 and should help in designing specific inhibitors of gelatin degradation.This work was supported by Grant SAF2012-31613 and Red Temática de Investigación Cooperativa en Cáncer Grant RD12/0036/0061 from the Ministry of Economy and Competitivity (Spain) (to A. G.-P.); by Grant S2010/ BMD-2314 (to A. G.-P.) from the Comunidad de Madrid/European Union;and by the Concerted Research Actions Grant GOA 2013–2015 and the fund for Scientific Research of Flanders (to G. O.).Peer reviewe

A Dyadic Perspective On Speech Accommodation and Social Connection: Both Partners\u27 Rejection Sensitivity Matters

Findings from confederate paradigms predict that mimicry is an adaptive route to social connection for rejection-sensitive individuals (Lakin, Chartrand, & Arkin, 2008). However, dyadic perspectives predict that whether mimicry leads to perceived connection depends on the rejection sensitivity (RS) of both partners in an interaction. We investigated these predictions in 50 college women who completed a dyadic cooperative task in which members were matched or mismatched in being dispositionally high or low in RS. We used a psycholinguistics paradigm to assess, through independent listeners\u27 judgments (N=162), how much interacting individuals accommodate phonetic aspects of their speech toward each other. Results confirmed predictions from confederate paradigms in matched RS dyads. However, mismatched dyads showed an asymmetry in levels of accommodation and perceived connection: Those high in RS accommodated more than their low-RS partner but emerged feeling less connected. Mediational analyses indicated that low-RS individuals\u27 nonaccommodation in mismatched dyads helped explain their high-RS partners\u27 relatively low perceived connection to them. Establishing whether mimicry is an adaptive route to social connection requires analyzing mimicry as a dyadic process influenced by the needs of each dyad member

A Synchrotron Mössbauer Spectroscopy Study of a Hydrated Iron-Sulfate at High Pressures

Szomolnokite is a monohydrated ferrous iron sulfate mineral, FeSO₄·H₂O, where the ferrous iron atoms are in octahedral coordination with four corners shared with SO4 and two with H₂O groups. While somewhat rare on Earth, szomolnokite has been detected on the surface of Mars along with several other hydrated sulfates and is suggested to occur near the surface of Venus. Previous measurements have characterized the local environment of the iron atoms in szomolnokite using Mössbauer spectroscopy at a range of temperatures and 1 bar. Our study represents a step towards understanding the electronic environment of iron in szomolnokite under compression at 300 K. Using a hydrostatic helium pressure-transmitting medium, we explored the pressure dependence of iron’s site-specific behavior in a synthetic szomolnokite powdered sample up to 95 GPa with time-domain synchrotron Mössbauer spectroscopy. At 1 bar, the Mössbauer spectrum is well described by two Fe²⁺-like sites and no ferric iron, consistent with select conventional Mössbauer spectra evaluations. At pressures below 19 GPa, steep gradients in the hyperfine parameters are most likely due to a structural phase transition. At 19 GPa, a fourth site is required to explain the time spectrum with increasing fractions of a low quadrupole splitting site, which could indicate the onset of another transition. Above 19 GPa we present three different models, including those with a high- to low-spin transition, that provide reasonable scenarios of electronic environment changes of the iron in szomolnokite with pressure. We summarize the complex range of Fe²⁺ spin transition characteristics at high-pressures by comparing szomolnokite with previous studies on ferrous-iron bearing phases

Steps to Opening Scientific Inquiry: Pre-Service Teachers’ Practicum Experiences with a New Support Framework

This qualitative multiple-comparative case study investigates (1) The reported experiences and impressions of four pre-service teachers (PTs) on practicum placement in four different classrooms (grades 1–9) where a new Steps to Inquiry (SI) framework was being utilized to support students conducting open inquiry; (2) The relative dispositions of the PTs toward conducting open inquiry, as indicated by their core conceptions regarding science, the purpose of education, effective teaching, and the capacity of students. Findings indicate that (1) although there were differences in the experiences of the four PTs, all four had an opportunity to observe and/or facilitate students conducting open inquiry with the SI framework, and after the practicum, all of them reported that they would like to include open inquiry in their own classrooms in the future; (2) one PT already possessed core conceptions indicative of a favorable disposition toward open inquiry before the placement; another altered her core conceptions substantially toward a favorable disposition during the placement; a third altered her conceptions regarding the capacity of students; and one PT maintained core conceptions indicative of a disposition that was not favorable to open inquiry despite the pronouncements that she would like to conduct open inquiry with students in their own future classroom. Possible reasons for the differences in the responses of the four pre-services teachers to the practicum placement are discussed

On the Perceptual Organization of Speech

A general account of auditory perceptual organization has developed in the past 2 decades. It relies on primitive devices akin to the Gestalt principles of organization to assign sensory elements to probable groupings and invokes secondary schematic processes to confirm or to repair the possible organization. Although this conceptualization is intended to apply universally, the variety and arrangement of acoustic constituents of speech violate Gestalt principles at numerous junctures, cohering perceptually, nonetheless. The authors report 3 experiments on organization in phonetic perception, using sine wave synthesis to evade the Gestalt rules and the schematic processes alike. These findings falsify a general auditory account, showing that phonetic perceptual organization is achieved by specific sensitivity to the acoustic modulations characteristic of speech signals

A Comparison of Phonetic Convergence in Conversational Interaction and Speech Shadowing

Phonetic convergence is a form of variation in speech production in which a talker adopts aspects of another talker\u27s acoustic–phonetic repertoire. To date, this phenomenon has been investigated in non-interactive laboratory tasks extensively and in conversational interaction to a lesser degree. The present study directly compares phonetic convergence in conversational interaction and in a non-interactive speech shadowing task among a large set of talkers who completed both tasks, using a holistic AXB perceptual similarity measure. Phonetic convergence occurred in a new role-neutral conversational task, exhibiting a subtle effect with high variability across talkers that is typical of findings reported in previous research. Conversational phonetic convergence did not differ by talker sex on average, but relationships between speech shadowing and conversational convergence differed according to talker sex, with female talkers showing no consistency across settings in their relative levels of convergence and male talkers showing a modest relationship. These findings indicate that phonetic convergence is not directly compatible across different settings, and that phonetic convergence of female talkers in particular is sensitive to differences across different settings. Overall, patterns of acoustic–phonetic variation and convergence observed both within and between different settings of language use are inconsistent with accounts of automatic perception-production integration

Programa de Intervención Cognitivo-Conductual y Familiar para el Tratamiento de Adolescentes con Adicción a la Cocaína

La adicción a la cocaína es un problema de salud pública con prevalencia ascendente. La edad de inicio de consumo se está reduciendo, poniendo en riesgo la salud de los adolescentes, quienes todavía en desarrollo, se ven más gravemente afectados por su consumo, tanto a nivel físico como psicológico. Por ello, el objetivo del trabajo es el diseño de un programa de intervención eficaz para adolescentes con adicción a la cocaína que persiga la abstinencia, la prevención de recaídas y la mejora de su calidad de vida. Se fundamenta en Terapia Cognitivo Conductual (TCC) y Terapia Familiar (TF), las cuales han demostrado eficacia en adultos. Participarán 8 jóvenes de entre 15 y 18 años y un máximo de 16 familiares. Se compone de 37 sesiones con formato grupal e individual, además de 4 sesiones de evaluación de eficacia del programa. La frecuencia de las sesiones es semanal con evaluación a los 3 y 9 meses. Se espera que, al finalizar el programa, presenten habilidades para mantenerse abstemios, un menor craving y una mejora en su calidad de vida a corto y largo plazo. Resulta una propuesta innovadora por la combinación de TCC y TF y la especificidad de su población diana.<br /