Various Approximations for the Isotopic Thermal Diffusion Factor. I. Application to Helium Isotopes

arious formulae for the isotopic Thermal diffusion factor have been reviewed and a new formula has been derived. Numerical calculations have been performed for the particular case of He3-He4 in a region where quantum effects are negligible. These calculations establish the relative adequacy of a comparatively simpler formula advanced by us and will be useful to interpret the recent experimental results of Saxena, Kelley and Watson on the thermal diffusion factor as a function of temperature

Effect of L-Ascorbic Acid on the Glycogen Contents During Mercury Intoxication in the Freshwater Bivalve, Parreysia Cylindrica

Freshwater bivalve, Parreysia cylindrica was exposed to acute (0.6 ppm) and chronic (0.12 ppm) doses of HgCl2 and HgCl2 with several concentrations of ascorbic acid. Glycogen contents from mantle, foot, gills, gonads and digestive glands were estimated after 24 hours and 96 hours of acute and 7 days and 21 days of chronic exposure from each group of test animals. Depletion of glycogen contents in different tissues caused due to mercury stress was much more as compared to those exposed to HgCl2 with ascorbic acid

Modeling of solidification process in a rotary electromagnetic stirrer

A macroscopic model of the solidification process in a rotary electromagnetic stirrer is presented. The fluid flow, heat, and mass transfer inside a rotary stirrer are modeled using, 3-D swirl flow equations in which turbulent flow is simulated using a k-ε model. A hybrid model is used to represent the mushy zone, which is considered to be divided into two regions: a coherent region and a noncoherent region. Each region is represented by a separate set of governing equations. An explicit time-stepping scheme is used for solving the coupled temperature and concentration fields, while an implicit scheme is used for solving equations of motion. The coupling relations also include eutectic solidification, which is an important feature in modeling solidification with electromagnetic stirring, especially in the context of the formation of semi-solid slurry. The results from the present numerical solution agree well with those corresponding to experiments reported in literature

Association between architectural parameters and burden of tuberculosis in three resettlement colonies of M-East Ward, Mumbai, India

Architecture and site planning play an important role in ensuring houses receive good light and ventilation and in turn have a healthy and livable environment. To investigate the strength of association between structural factors of slum resettlement colonies buildings and the burden of tuberculosis (TB), a questionnaire-based semi-quantitative survey of 4080 households was carried out in three resettlement colonies (Lallubhai Compound, Natwar Parekh Compound and PMG colony) with questions on architectural patterns, socioeconomic details as well as occurrence of TB in any member of the household. Computational modelling for Sky View Factor, Daylight Autonomy and Natural Ventilation in the houses of all three colonies was also performed. The results show that lower floors do not have access to sufficient light and ventilation in the living area. All colonies had poor Sky View Factors, Daylight Autonomy and ventilation. Occurrence of TB was strongly associated with lower floor of the house, closed or only partially openable windows, lack of exhaust fans as well as the built environment of the houses. The study also traced back the poor conditions of light and ventilation to the relaxations in development control regulations (DCR 1991 and modifications) given to rehabilitation and slum redevelopment buildings. The study recommends better planning and architecture measures to be taken by the city government to bring improvements in housing and avert a public health crisi

An alum [KAl (SO4)2.12H2O] catalyzed microwave assisted multicomponent synthesis of bioactive functionalized benzylpyrazolyl coumarin and quinolinone derivatives in PEG

An efficient and environmentally benign method has been developed for the synthesis of benzylpyrazolyl coumarin and quinolinone derivatives, hydroxy coumarin derivatives using Alum [KAl (SO4)2.12H2O] catalyst and Polyethylene glycol as green solvent under microwave condition. Keywords: Knoevenagel, Michael addition reaction, coumarins, quinolinones, alum, polyethylene glycol, multicomponent microwave irradiation method

AUTOMATIC DOCUMENT CLUSTERING

ABSTRACT Automatic document clustering has played an important role in the field of information retrieval. The aim of the developed this system is to store documents in clusters and to improve its retrieval efficiently. Clustering is a technique aimed at grouping a set of objects into clusters. Document clustering is the task of combining a set of documents into clusters so that similar type of documents will be store in one cluster. We applied non overlapping method to store document into cluster. In this project, we write an algorithm which will calculate similarity of document's keywords and according to its similarity points it will either put into existing cluster or new cluster is created and stored into that cluster. To find keywords from document various techniques are used like tokenization, stop word removal, stemmer, TF*IDF calculation

A prospective, multicentre, observational cohort study of analgesia and outcome after pneumonectomy

Background Meta-analysis and systematic reviews of epidural compared with paravertebral blockade analgesia techniques for thoracotomy conclude that although the analgesia is comparable, paravertebral blockade has a better short-term side-effect profile. However, reduction in major complications including mortality has not been proven. Methods The UK pneumonectomy study was a prospective observational cohort study in which all UK thoracic surgical centres were invited to participate. Data presented here relate to the mode of analgesia and outcome. Data were analysed for 312 patients having pneumonectomy at 24 UK thoracic surgical centres in 2005. The primary endpoint was a major complication. Results The most common type of analgesia used was epidural (61.1%) followed by paravertebral infusion (31%). Epidural catheter use was associated with major complications (odds ratio 2.2, 95% confidence interval 1.1–3.8; P=0.02) by stepwise logistic regression analysis. Conclusions An increased incidence of clinically important major post-pneumonectomy complications was associated with thoracic epidural compared with paravertebral blockade analgesia. However, this study is unable to provide robust evidence to change clinical practice for a better clinical outcome. A large multicentre randomized controlled trial is now needed to compare the efficacy, complications, and cost-effectiveness of epidural and paravertebral blockade analgesia after major lung resection with the primary outcome of clinically important major morbidity

Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations

The surface drying process is an important technology in the pharmaceutical, biomedical, and food industries. The final stage of formulation development (i.e., the drying process) faces several challenges, and overall mastering depends on the end step. The advent of new emerging technologies paved the way for commercialization. Thin film freezing (TFF) is a new emerging freeze-drying technique available for various treatment modalities in drug delivery. TFF has now been used for the commercialization of pharmaceuticals, food, and biopharmaceutical products. The present review highlights the fundamentals of TFF along with modulated techniques used for drying pharmaceuticals and biopharmaceuticals. Furthermore, we have covered various therapeutic applications of TFF technology in the development of nanoformulations, dry powder for inhalations and vaccines. TFF holds promise in delivering therapeutics for lung diseases such as fungal infection, bacterial infection, lung dysfunction, and pneumonia

Squaramide—Naphthalimide Conjugates as “Turn-On” Fluorescent Sensors for Bromide Through an Aggregation-Disaggregation Approach

The syntheses of two new squaramide-naphthalimide conjugates (SQ1 and SQ2) are reported where both compounds have been shown to act as selective fluorescence “turn on” probes for bromide in aqueous DMSO solution through a disaggregation induced response. SQ1 and SQ2 displayed a large degree of self-aggregation in aqueous solution that is disrupted at increased temperature as studied by 1H NMR and Scanning Electron Microscopy (SEM). Moreover, the fluorescence behavior of both receptors was shown to be highly dependent upon the aggregation state and increasing temperature gave rise to a significant increase in fluorescence intensity. Moreover, this disaggregation induced emission (DIE) response was exploited for the selective recognition of certain halides, where the receptors gave rise to distinct responses related to the interaction of the various halide anions with the receptors. Addition of F− rendered both compounds non-emissive; thought to be due to a deprotonation event while, surprisingly, Br− resulted in a dramatic 500–600% fluorescence enhancement thought to be due to a disruption of compound aggregation and allowing the monomeric receptors to dominate in solution. Furthermore, optical sensing parameters such as limits of detection and binding constant of probes were also measured toward the various halides (F−, Cl−, Br−, and I−) where both SQ1 and SQ2 were found to sense halides with adequate sensitivity to measure μM levels of halide contamination. Finally, initial studies in a human cell line were also conducted where it was observed that both compounds are capable of being taken up by HeLa cells, exhibiting intracellular fluorescence as measured by both confocal microscopy and flow cytometry. Finally, using flow cytometry we were also able to show that cells treated with NaBr exhibited a demonstrable spectroscopic response when treated with either SQ1 or SQ2

Rapeseed-Mustard Breeding in India: Scenario, Achievements and Research Needs

Brassica spp., commonly known as rapeseed-mustard, plays a significant role in the Indian economy by providing edible oils, vegetables, condiments and animal feed. Globally, India holds second and third position in rapeseed-mustard area under cultivation and production, respectively. However, anthropogenically accelerated climate change thwarts yield potential of rapeseed-mustard by employing abiotic (drought, flood, temperature variation and salinity) and biotic (disease and insects) stresses. Various approaches such as molecular breeding, pre-breeding, −omics and biotechnological interventions have been used to develop varieties for improved yield and oil quality, climate resilient and resistance or tolerance to abiotic and biotic stresses. In this context, this chapter highlighted the different cytoplasmic male sterility (CMS) sources and their potential use for hybrid development. At the end, this chapter also enlisted salient achievement by the government and non-government institutes and briefly described the future perspective for improvement of rapeseed-mustard in India