Acetylator status influences bioavailability of isoniazid in patients with advanced HIV disease

Patients with advanced HIV disease may exhibit malabsorption of anti-tuberculosis(TB) drugs. We evaluated the effect of isoniazid (INH) acetylator status on the bioavailability of INH in HIV-infected patients with and without tuberculosis, based on urinary excretion of the drug. Estimation of INH in urine collected up to 8 hours after oral administration of 300 mg INH were undertaken in 23 TB, 40 HIV and 26 HIV-TB patients. Determination of acetylator status of all these patients was also carried by differential estimations of INH and acetyl INH in urine collected between 5 and 6 hours after oral administration of 300 mg INH. Both slow and rapid acetylators in HIV and HIV-TB groups had significantly lower concentration of INH in urine compared to TB patients. The percent decrease in urinary excretion of INH was significantly higher in rapid than in slow acetylators, when compared to the corresponding TB patients. Acetylator status has an impact on the bioavailability of INH. Malbsorption in patients with advanced HIV disease may lead to decreased bioavailability of INH, particularly in rapid acetylators. Urinary estimation of INH provides reliable information on the bioavailability of the drug

Deceased donor organ procurement injuries in the United States

AIM: To determine the incidence of surgical injury during deceased donor organ procurements. METHODS: Organ damage was classified into three tiers, from 1-3, with the latter rendering the organ non-transplantable. For 12 consecutive months starting in January of 2014, 36 of 58 organ procurement organization's (OPO)'s prospectively submitted quality data regarding organ damage (as reported by the transplanting surgeon and confirmed by the OPO medical director) seen on the procured organ. RESULTS: These 36 OPOs recovered 5401 of the nations's 8504 deceased donors for calendar year 2014. A total of 19043 organs procured were prospectively analyzed. Of this total, 59 organs sustained damage making them non-transplantable (0 intestines; 4 pancreata; 5 lungs; 6 livers; 43 kidneys). The class 3 damage was spread over 22 (of 36) reporting OPO's. CONCLUSION: While damage to the procured organ is rare with organ loss being approximately 0.3% of procured organs, loss of potential transplantable organs does occur during procurement

Study of the distribution of Trace elements in soils in and around Mysore city, Karnataka

Soil samples collected from various places in and around Mysore were analyzed for the total trace elements such as Fe, Mn, Cu, Zn, Pb, and Cd. The results of the analysis indicate that the concentration of lead and cadmium in soils is below 2.5 mu g ml(-1) and 0.2 mu g ml(-1) respectively, which are the minimum detection levels, whereas the concentration of iron, manganese, copper, and zinc in most of the samples is within the global average ranges of 3%, 500-1000 mu g g(-1), 15-40 mu g g(-1), and 50-100 mu g g(-1), respectively. The investigated area has the presence of gneisses and schists, in which partly there are igneous intrusions and pegmatitic intrusions. There are amphibolite enclaves in gneisses that account for the higher concentration of trace elements. The lower concentration may be attributed to the presence of silicic type of rock

226Ra and 210Po in the soils of Mysore, Karnataka, India

The soil samples collected from the selected locations were analyzed for 226Ra and 210Po activity. The activity of 226Ra ranges from 2.0 ± 0.4 Bq kg-1 to 12.9 ± 1.3 Bq kg-1, whereas that of 210Po ranges from 7.6 ± 1.2 Bq kg-1 to 37.3 ± 2.4 Bq kg-1. The activity ratios of 210Po to 226Ra vary by an order of magnitude from place to place. The systematics of these ratios on the distances of the sampling sites from catchment zone water divide towards neighboring river basins, have been observe

Estimation of U, 226Ra, and 210Po concentrations in Cauvery River basin, South interior Karnataka Region, India

The radioactivity concentration of 210Po, 226Ra, and U in Cauvery river basin was analyzed using radiochemical analysis, emanometry, and LED fluorimetry, respectively. Due to transfer with water in cracks and pores, leaching, and heavy usage of phosphate fertilizers, 210Po, 226Ra, and U radionuclides get into the environmental samples studied. The 210Po concentration ranges from 0.7 ± 0.11 to 5.0 ± 0.7 and from 0.83 ± 0.12 to 5.2 ± 0.8 mBq L–1; the 226Ra concentration, from 11.7 ± 1.8 to 62 ± 9 and from 10.5 ± 1.6 to 68 ± 10 mBq L–1; and the U concentration, from 0.08 ± 0.01 to 4.4 ± 0.7 and from 2.0 ± 0.3 to 7.4 ± 1.1 ppb in river and borewell water samples, respectively