1,038 research outputs found
A nyĂlt hozzáfĂ©rĂ©stĹ‘l a nyĂlt tudomány felĂ© OpenAIRE-Advance (2018–2021) = From Open Access to Open Science: the OpenAIRE-Advance project (2018–2021)
An exciting new chapter of the OpenAIRE project-series was launched on January 1, 2018.
The mission of OpenAIRE-Advance is to support Open Access and Open Data mandates in Europe and worldwide. The project plays a strong role in strengthening and optimizing services with an end-user (everyone who’s been involved in the research lifecycle) optimized Dashboard system. One of its main goals is to make the Pan-European helpdesks more powerful through the NOAD (National Open Access Desk) system so that the NOADs will become key actors in consolidating the national Open Science movement. It commits the research society to Open Science in such a way as to channel Open Science as a service into the research lifecycle. Its primary task is to promote changes in scientific communication, so OpenAIRE will support the development of new generation repositories with new functionalities and new technologies.
Hungary is represented in the project by the University of Debrecen University and National Library. We take part in the three workpackages concentrating on the construction of dissemination and communication channels between stakeholders; strengthening and operating the NOAD network, thus providing stakeholders with assistance and training opportunities, and the development of information and training materials and providing trainings on Open Science
Adipocitokinek hatása a HDL mennyiségére és funkciójára az atherosclerosis szempontjából veszélyeztetett betegcsoportokban = The effect of adipocitokines on HDL level and function in atherosclerotic patients
Az adipocitokinek Ă©s a statin kezelĂ©s hatását tanulmányoztuk a HDL funkciĂłira Ă©relmeszesedĂ©s szempontjábĂłl fokozott kockázatĂş betegeken. ElhĂzott gyermekekben Ă©s felnĹ‘ttekben csökkent antioxidáns hatásĂş paraoxonáz (PON1) aktivitást, emelkedett proatherogĂ©n leptin Ă©s alacsonyabb antiatherogĂ©n adiponektin szinteket találtunk. A PON1 aktivitás negatĂvan korrelált a leptin, mĂg pozitĂvan az adiponektin szintekkel. SzĂ©les BMI tartományban a HDL összetĂ©telĂ©t befolyásolĂł LCAT inverz összefĂĽggĂ©st mutatott az elhĂzás mĂ©rtĂ©kĂ©vel, a leptin szintekkel Ă©s a CETP aktivitással. A szĂ©rum rezisztin szint a BMI-vel Ă©s a leptin szinttel negatĂv, mĂg a PON1 aktivitással pozitĂv korreláciĂłt mutatott. Hemodializált Ă©s vesetranszplantált betegekben a veseműködĂ©sre jellemzĹ‘ szĂ©rum Cystatin C szint befolyásolta a PON1 aktivitást. Kimutattuk, hogy a vesefunkciĂł romlásával a vĂ©dĹ‘ hatásĂş PON1 aktivitása csökken. A romlĂł vesefunkciĂłt jellemzĹ‘ emelkedett CysC Ă©s homocisztein szint negatĂvan korrelált a PON1 aktivitással. A vártnál nagyobb mĂ©rtĂ©kű eltĂ©rĂ©st találtunk a PON1 genotĂpus Ă©s fenotĂpus meghatározás eredmĂ©nyei között hemodializált Ă©s vesetranszplantált betegekben. Igazoltuk, hogy a PON1 fenotĂpus mĂłdosĂtja a statin kezelĂ©s PON1 aktivitásra Ă©s lipidparamĂ©terekre kifejtett hatását. EredmĂ©nyeink azt mutatják, hogy az atorvastatin kezelĂ©s megváltoztatja a HDL szubfrakciĂłk arányát, mely a PON1 aktivitás emelĂ©sĂ©n keresztĂĽl fokozza annak antiatherogĂ©n hatását hyperlipidaemiás betegekben. | We investigated the effects of adipokines and statin treatment on HDL function in patients with enhanced risk for atherogenesis. Lower activity of antioxidant paraoxonase(PON1), and a higher proatherogen leptin and a lower antiatherogen adiponectin levels were found in both obese children and adults. PON1 activity showed an inverse correlation with leptin and a positive correlation with adiponectin levels.In a population with a wide range of BMI, HDL composition influencing LCAT, correlated inversely with obesity, leptin levels and CETP activity.Serum levels of resistin were correlated negatively with BMI and serum levels of leptin, but correlated positively with PON1 activity. Serum cystatin C level, a parameter of kidney function, influenced PON1 activity in hemodialyzed and renal transplanted patients.We demonstrated that reduced kidney function was accompanied by a decrease in protective PON1 activity.Increased homocysteine and CysC levels, the indicators of impaired kidney function correlated negatively with PON1 activity.We observed unexpectedly high discordances between PON1 phenotype and genotype assessments in patients with CKD and in renal transplant recipients. We proved that PON1 phenotype modifies the effect of statins on PON1 activity and lipid parameters. Our results showed that atorvastatin treatment alters the proportion of HDL subfractions, which may improve its antiatherogenic effect via enhancement of the PON1 activity in hyperlipidemic patients
Serum obestatin level strongly correlates with lipoprotein subfractions in non-diabetic obese patients
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Blood Catalase Activities, Catalase Gene Polymorphisms and Acatalasemia Mutations in Hungarian Patients with Diabetes Mellitus
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Particulate production during debonding of fixed appliances:Laboratory investigation and randomized clinical trial to assess the effect of using flash-free ceramic brackets
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