Domestic abuse victims’ perceptions of abuse and support: a narrative study

The current study sought to investigate the developmental and social characteristics of a group of victimised women to develop understanding into the factors which put local women at risk for victimisation and enhance the local support services for these women. Twelve women from local support services were interviewed about their experiences of violence. The aim of these interviews was to identify patterns within these women’s narratives which can be explored and developed for future applications Interviews were analysed using thematic analysis which resulted in four themes: (1) childhood characteristics; (2) first sexual encounters; (3) quality of life; and (4) supporting services. The results provide an extraordinary opportunity to enhance the support services provided for vulnerable women and girls in the local community. These results have not only aided in advancing the current research but also developing current service-providers for this local population. More specifically, the results have indicated a number of characteristics which place women at risk of victimisation, more importantly, the results have demonstrated the importance of exploring other services that may be beneficial for the recovery of these woman. In essence, the woman taking part in this study highlighted areas which encourage future exploration for both researchers and service providers. Clearly, before definite conclusions can be drawn, more research evaluations need to be carried out to explore the characteristics that put women at risk of violence and the services which may aid in their recovery

Exploring the belief systems of domestic abuse victims using Smallest Space Analysis (SSA)

Research exploring domestic abuse victims has primarily focused on the shorter term avenues of support for victims and the risk factors which put women at risk of victimization. There is limited research exploring the belief systems of domestically abused women that need to be targeted to achieve longer term effects. The present study therefore explored the association between the beliefs of abused women and their experiences as victims. Twenty-one women with a history of domestic abuse were asked about their attitudes towards authority figures and perceived opportunities around the time of their abusive experience. Data were analyzed using Smallest Space Analysis (SSA). Four distinct belief themes (personal responsibility, antisocial attitudes, environmental factors, and negative police attitudes) were found in the analysis. The findings highlighted not only the importance of considering the long standing and personalized beliefs of abuse victims, but also demonstrates the need for support services to offer more personalized support to abuse victims to help change their belief systems. Although this research sets the groundwork in understanding the beliefs of domestic abuse victims, these results need to be built upon with future research examining the wider implications of targeting the belief systems of domestically abused women

Observing plasticity of the auditory system: Volumetric decreases along with increased functional connectivity in aspiring professional musicians

Playing music relies on several sensory systems and the motor system, and poses strong demands on control processes, hence, offering an excellent model to study how experience can mold brain structure and function. Although most studies on neural correlates of music expertise rely on cross-sectional comparisons, here we compared within-person changes over time in aspiring professionals intensely preparing for an entrance exam at a University of the Arts to skilled amateur musicians not preparing for a music exam. In the group of aspiring professionals, we observed gray-matter volume decrements in left planum polare, posterior insula, and left inferior frontal orbital gyrus over a period of about 6 months that were absent among the amateur musicians. At the same time, the left planum polare, the largest cluster of structural change, showed increasing functional connectivity with left and right auditory cortex, left precentral gyrus, left supplementary motor cortex, left and right postcentral gyrus, and left cingulate cortex, all regions previously identified to relate to music expertise. In line with the expansion–renormalization pattern of brain plasticity (Wenger et al., 2017a. Expansion and renormalization of human brain structure during skill acquisition. Trends Cogn Sci. 21:930–939.), the aspiring professionals might have been in the selection and refinement period of plastic change

Socioeconomic Inequalities in Physical Activity and Sedentary Behaviour among the Chilean Population:A Systematic Review of Observational Studies

Socioeconomic inequalities in physical (in)activity and sedentary behaviours are key mediators in obesity and health socioeconomic inequalities. Considering the high and uneven obesity rates in Chile, this review aims to systematically assess the socioeconomic inequalities in physical activity (PA) and sedentary behaviour (SB) among the Chilean population from different age groups. Peer-reviewed and grey literature were searched from inception until 31st December 2019 in PubMed, Scopus, PsycINFO, Web of Sciences and LILACS. Publications in English and Spanish, from observational studies that reported the comparison of at least one indicator of PA or SB between at least two groups of different socioeconomic positions (SEP), from the general Chilean population, were included. Data searches, screening, extraction, and quality assessment, using the Newcastle Ottawa Quality Assessment Scale for observational studies, were conducted by two independent researchers. Seventeen articles (from 16 studies) met the inclusion criteria (14 cross-sectional; two cohort). Across these, quality was considered low, medium and high for 19%, 69% and 13%, respectively. Results showed consistent evidence for a lower leisure-time PA and sitting time, and higher physical inactivity among adults from the lower, compared to the highest, SEP groups. Associations between SEP and total PA, moderate-to-vigorous PA, low PA, and transport and work-related PA were inconsistent. These findings provide insights to public health and physical activity researchers and policymakers aiming to reduce socioeconomic inequalities in PA and SB in Chile and other countries

The role of SH3BP2 in the pathophysiology of cherubism

Cherubism is a rare bone dysplasia that is characterized by symmetrical bone resorption limited to the jaws. Bone lesions are filled with soft fibrous giant cell-rich tissue that can expand and cause severe facial deformity. The disorder typically begins in children at ages of 2-5 years and the bone resorption and facial swelling continues until puberty; in most cases the lesions regress spontaneously thereafter. Most patients with cherubism have germline mutations in the gene encoding SH3BP2, an adapter protein involved in adaptive and innate immune response signaling. A mouse model carrying a Pro416Arg mutation in SH3BP2 develops osteopenia and expansile lytic lesions in bone and some soft tissue organs. In this review we discuss the genetics of cherubism, the biological functions of SH3BP2 and the analysis of the mouse model. The data suggest that the underlying cause for cherubism is a systemic autoinflammatory response to physiologic challenges despite the localized appearance of bone resorption and fibrous expansion to the jaws in humans

Quantitative identification of functional connectivity disturbances in neuropsychiatric lupus based on resting-state fMRI: a robust machine learning approach

Neuropsychiatric systemic lupus erythematosus (NPSLE) is an autoimmune entity comprised of heterogenous syndromes affecting both the peripheral and central nervous system. Research on the pathophysiological substrate of NPSLE manifestations, including functional neuroimaging studies, is extremely limited. The present study examined person-specific patterns of whole-brain functional connectivity in NPSLE patients (n = 44) and age-matched healthy control participants (n = 39). Static functional connectivity graphs were calculated comprised of connection strengths between 90 brain regions. These connections were subsequently filtered through rigorous surrogate analysis, a technique borrowed from physics, novel to neuroimaging. Next, global as well as nodal network metrics were estimated for each individual functional brain network and were input to a robust machine learning algorithm consisting of a random forest feature selection and nested cross-validation strategy. The proposed pipeline is data-driven in its entirety, and several tests were performed in order to ensure model robustness. The best-fitting model utilizing nodal graph metrics for 11 brain regions was associated with 73.5% accuracy (74.5% sensitivity and 73% specificity) in discriminating NPSLE from healthy individuals with adequate statistical power. Closer inspection of graph metric values suggested an increased role within the functional brain network in NSPLE (indicated by higher nodal degree, local efficiency, betweenness centrality, or eigenvalue efficiency) as compared to healthy controls for seven brain regions and a reduced role for four areas. These findings corroborate earlier work regarding hemodynamic disturbances in these brain regions in NPSLE. The validity of the results is further supported by significant associations of certain selected graph metrics with accumulated organ damage incurred by lupus, with visuomotor performance and mental flexibility scores obtained independently from NPSLE patients. View Full-Text Keywords: neuropsychiatric systemic lupus erythematosus; rs-fMRI; graph theory; functional connectivity; surrogate data; machine learning; visuomotor ability; mental flexibilit