The XII century towers, a benchmark of the Rome countryside almost cancelled. The safeguard plan by low cost uav and terrestrial DSM photogrammetry surveying and 3D Web GIS applications

“Giving a bird-fly look at the Rome countryside, throughout the Middle Age central period, it would show as if the multiple city towers has been widely spread around the territory” on a radial range of maximum thirty kilometers far from the Capitol Hill center (Carocci and Vendittelli, 2004). This is the consequence of the phenomenon identified with the “Incasalamento” neologism, described in depth in the following paper, intended as the general process of expansion of the urban society interests outside the downtown limits, started from the half of the XII and developed through all the XIII century, slowing down and ending in the following years. From the XIX century till today the architectural finds of this reality have raised the interest of many national and international scientists, which aimed to study and catalog them all to create a complete framework that, cause of its extension, didn’t allow yet attempting any element by element detailed analysis. From the described situation has started our plan of intervention, we will apply integrated survey methods and technologies of terrestrial and UAV near stereo-photogrammetry, by the use of low cost drones, more than action cameras and reflex on extensible rods, integrated and referenced with GPS and topographic survey. In the final project we intend to produce some 3D scaled and textured surface models of any artifact (almost two hundreds were firstly observed still standing), to singularly study the dimensions and structure, to analyze the building materials and details and to formulate an hypothesis about any function, based even on the position along the territory. These models, successively georeferenced, will be imported into a 2D and 3D WebGIS and organized in layers made visible on basemaps of reference, as much as on historical maps

Regulation of NKG2D-Dependent NK Cell Functions: The Yin and the Yang of Receptor Endocytosis.

Natural-killer receptor group 2, member D (NKG2D) is a well characterized natural killer (NK) cell activating receptor that recognizes several ligands poorly expressed on healthy cells but up-regulated upon stressing stimuli in the context of cancer or viral infection. Although NKG2D ligands represent danger signals that render target cells more susceptible to NK cell lysis, accumulating evidence demonstrates that persistent exposure to ligand-expressing cells causes the decrease of NKG2D surface expression leading to a functional impairment of NKG2D-dependent NK cell functions. Upon ligand binding, NKG2D is internalized from the plasma membrane and sorted to lysosomes for degradation. However, receptor endocytosis is not only a mechanism of receptor clearance from the cell surface, but is also required for the proper activation of signalling events leading to the functional program of NK cells. This review is aimed at providing a summary of current literature relevant to the molecular mechanisms leading to NKG2D down-modulation with particular emphasis given to the role of NKG2D endocytosis in both receptor degradation and signal propagation. Examples of chronic ligand-induced down-regulation of NK cell activating receptors other than NKG2D, including natural cytotoxicity receptors (NCRs), DNAX accessory molecule-1 (DNAM1) and CD16, will be also discussed

The Steiner problem for infinitely many points

Let AA be a given compact subset of the euclidean space. We consider the problem of finding a compact connected set SS of minimal 11-dimensional Hausdorff measure, among all compact connected sets containing AA. We prove that when AA is a finite set any minimizer is a finite tree with straight edges, thus recovery the classical Steiner Problem. Analogously, in the case when AA is countable, we prove that every minimizer is a (possibly) countable union of straight segments

Papillomavirus E5: the smallest oncoprotein with many functions

Papillomaviruses (PVs) are established agents of human and animal cancers. They infect cutaneous and mucous epithelia. High Risk (HR) Human PVs (HPVs) are consistently associated with cancer of the uterine cervix, but are also involved in the etiopathogenesis of other cancer types. The early oncoproteins of PVs: E5, E6 and E7 are known to contribute to tumour progression. While the oncogenic activities of E6 and E7 are well characterised, the role of E5 is still rather nebulous. The widespread causal association of PVs with cancer makes their study worthwhile not only in humans but also in animal model systems. The Bovine PV (BPV) system has been the most useful animal model in understanding the oncogenic potential of PVs due to the pivotal role of its E5 oncoprotein in cell transformation. This review will highlight the differences between HPV-16 E5 (16E5) and E5 from other PVs, primarily from BPV. It will discuss the targeting of E5 as a possible therapeutic agent

Massive Grant-Free Access with Massive MIMO and Spatially Coupled Replicas

Massive multiple access schemes, capable of serving a large number of uncoordinated devices while fulfilling reliability and latency constraints, are proposed. The schemes belong to the class of grant-free coded random access protocols and are tailored to massive multiple input multiple output (MIMO) base station processing. High reliability is obtained owing to an intra-frame spatial coupling effect, triggered by a simple device access protocol combined with acknowledgements (ACKs) from the base station. To provide system design guidelines, analytical bounds on error floor and latency are also derived. The proposed schemes are particularly interesting to address the challenges of massive machine-type communications in the framework of next generation massive multiple access systems