10,250 research outputs found
The role played by the molecular weight and acetylation degree in modualting the stiffness and elasticity of chitosan gels
A broad library of chitosans was produced varying the molecular weight and the fraction of acetylated units, FA. The produced chitosans were used for the formation of wall-to-wall cylindrical gels through a controlled external gelation using tripolyphosphate (TPP) as cross-linker. The resulting gels were analyzed by rheometry. Viscosity average degree of polymerization (DPv\uaf)\u202f>\u202f152 was shown to be required for the formation of stable gels. Both gel stiffness and gel rupture strength were proportional to the molecular weight regardless of the applied deformation. Increasing acetylation produced a marked reduction of the shear modulus, but, in parallel, switched the networks from rigid and brittle to weak and elastic. Intriguingly, gels made of chitosan with FA\u202f=\u202f0.37 displayed notable elasticity, i.e. up to 90% of applied strain falls into linear regime. These findings suggest that the frequency of glucosamine (D unit) and N-acetyl-glucosamine (A unit) contribute to a subtle structure-property relationship in chitosan-TPP gels
Exercise respiratory cycle time components in patients with emphysema
Background: We have recently demonstrated that in patients with COPD the severity of emphysema (E) measured by high resolution computed tomography (HRCT) correlated with: ratio VTpeak/FEV1; VE/VCO2 slope and PETCO2 values at peak exercise. The aim of this study was to further investigate if exercise respiratory cycle time components correlated with % of E measured by HRCT. Method: Twelve patients (age = 65±8 yrs; FEV1 = 55±17%pred) with moderate to severe E (quantified by lung HRCT as % voxels < −910 HU) were evaluated with incremental cardiopulmonary exercise testing (CPET). Mean inspiratory time (TiM), mean total respiratory cycle time (TtotM), mean expiratory time during exercise (TeM) and mean expiratory time during the last third of exercise (TeM-end), has been calculated.
Results: Both TeM and TeM-end had a good linear correlation with % of E (r = 0,61; p = 0,004 and r = 0,63; p = 0,003). Moreover, by dividing the patients in two groups based on the % of E (>50% and <50%), we observed that patients with higher % of E had longer TeM (TeM: 1,72±0,26sec vs 1,34±0,27sec, p = 0,005) and TeM-end. A good linear correlation has been observed also between TeM and PETCO2 and VE/VCO2 (r = 0,64; p = 0,002 and r = 0,7; p = 0,0005). TeM did not correlated with resting lung function values or inspiratory capacity (IC).
Conclusion: The data confirm that distinct physiologic response pattern can be detected at CPET in these patients
Displacement power spectrum measurement of a macroscopic optomechanical system at thermal equilibrium
The mirror relative motion of a suspended Fabry-Perot cavity is studied in
the frequency range 3-10 Hz. The experimental measurements presented in this
paper, have been performed at the Low Frequency Facility, a high finesse
optical cavity 1 cm long suspended to a mechanical seismic isolation system
identical to that one used in the VIRGO experiment. The measured relative
displacement power spectrum is compatible with a system at thermal equilibrium
within its environmental. In the frequency region above 3 Hz, where seismic
noise contamination is negligible, the measurement distribution is stationary
and Gaussian, as expected for a system at thermal equilibrium. Through a simple
mechanical model it is shown that: applying the fluctuation dissipation theorem
the measured power spectrum is reproduced below 90 Hz and noise induced by
external sources are below the measurement.Comment: 11 pages, 9 figures, 2 tables, to be submitte
An identification procedure for woolly soft-flesh peaches by instrumental assessment
Woolliness in peaches, a negative attribute of sensory texture characterized by the lack of crispness and juiciness, also known as mealiness in other fruits, has been identified fruit-by fruit by instrumental means. The use of a non-supervised clustering data analysis procedure, studying crispness and juiciness, enables four instrumental degrees of texture degradation to be defined, of which woolliness appears to be the last stage. This procedure also provides some information on several experimental factors (ripeness stages, storage time and storage temperature) with regard to the onset of woolliness. It is confirmed through this study that, in Maycrest peaches, woolliness starts to appear after 2 weeks of storage at 5°C. Fruits classified at harvest in 'first' and 'second' ripeness stages are more susceptible to woolliness than those in the third ripeness stage. This clustering procedure may also be effective for studying other species, varieties and quality attributes of fruit
Preliminary archaeometric analysis on a marble bas-relief of unknown origin
This paper addresses an archaeometric study of a marble bas-relief seized by the Cosenza Carabinieri Unit for the Protection of Cultural Heritage and Anti-Counterfeiting (Calabria, Italy). The research aimed to collect data on the authenticity of the artwork, providing indications about the compositional features of the sampled materials. An analytical approach based on the use of SEM-EDX and FT-IR techniques along with a stylistic evaluation of the artwork, allowed us to answer the requests posed by the institutions and to set the work in a different historical context from the Roman production
Measurements and tests on FBK silicon sensors with an optimized electronic design for a CTA camera
In October 2013, the Italian Ministry approved the funding of a Research &
Development (R&D) study, within the "Progetto Premiale TElescopi CHErenkov made
in Italy (TECHE)", devoted to the development of a demonstrator for a camera
for the Cherenkov Telescope Array (CTA) consortium. The demonstrator consists
of a sensor plane based on the Silicon Photomultiplier (SiPM) technology and on
an electronics designed for signal sampling. Preliminary tests on a matrix of
sensors produced by the Fondazione Bruno Kessler (FBK-Trento, Italy) and on
electronic prototypes produced by SITAEL S.p.A. will be presented. In
particular, we used different designs of the electronics in order to optimize
the output signals in terms of tail cancellation. This is crucial for
applications where a high background is expected, as for the CTA experiment.Comment: 5 pages, 6 figures; Proceedings of the 10th Workshop on Science with
the New Generation of High-Energy Gamma-ray experiments (SciNeGHE) -
PoS(Scineghe2014)00
Complex Coacervates between a Lactose-Modified Chitosan and Hyaluronic Acid as Radical-Scavenging Drug Carriers
Complex coacervation of two oppositely charged polysaccharides, namely a lactose-modified chitosan (CTL) and hyaluronan (HA), was investigated in this study. Coacervates of the two polysaccharides were prepared by drop-by-drop injection of HA into CTL. Transmittance and dynamic light scattering (DLS) measurements in combination with TEM analyses demonstrated the formation of spheroidal colloids in the nano-/microsize range showing good homogeneity. Strikingly, the presence of 150 mM supporting NaCl did not hamper the colloid formation. Stability studies on selected formulations demonstrated that HA/CTL coacervates were stable up to 3 weeks at 37 \ub0C and behaved as pH-responsive colloids since transition from entangled to disentangled chains was attained for a proper pH range. The possibility of freeze-drying the coacervates for storage purposes and the ability of encapsulating selected payloads were investigated as well, for two values of the fraction of the lactitol side-chain substitution (FL). Finally, biological tests using human neutrophils were undertaken at acidic pH value (pH = 6.0): under such experimental conditions, akin to those frequently occurring in the inflammatory microenvironment, coacervates scavenged reactive oxygen species (ROS) generated by these cells in basal conditions. Given the well documented bioactivity of CTL with respect to chitosan toward cartilage regeneration, these findings point to a possible application of HA/CTL-based colloids as scavenging and bioactive carriers for the delivery of therapeutic molecules at confined inflamed sites such as knee joints
Magnetic coupling to the Advanced Virgo payloads and its impact on the low frequency sensitivity
We study the electromagnetic coupling of the Advanced Virgo (AdV) Input
Mirror Payload (IMP) in response to a slowly time-varying magnetic field. As
the problem is not amenable to analytical solution, we employ and validate a
finite element (FE) analysis approach. The FE model is built to represent as
faithfully as possible the real object and it has been validated by comparison
with experimental measurements. The intent is to estimate the induced currents
and the magnetic field in the neighbourhood of the payload. The procedure found
21 equivalent electrical configurations that are compatible with the
measurements. These have been used to compute the magnetic noise contribution
to the total AdV strain noise. At the current stage of development AdV seems to
be unaffected by magnetic noise, but we foresee a non-negligible coupling once
AdV reaches the design sensitivity.Comment: 8 pages, 8 figures, 2 table
Inertial control of the mirror suspensions of the VIRGO interferometer for gravitational wave detection
In order to achieve full detection sensitivity at low frequencies, the
mirrors of interferometric gravitational wave detectors must be isolated from
seismic noise. The VIRGO vibration isolator, called 'superattenuator', is fully
effective at frequencies above 4 Hz. Nevertheless, the residual motion of the
mirror at the mechanical resonant frequencies of the system are too large for
the interferometer locking system and must be damped. A multidimensional
feedback system, using inertial sensors and digital processing, has been
designed for this purpose. An experimental procedure for determining the
feedback control of the system has been defined. In this paper a full
description of the system is given and experimental results are presented.Comment: 17 pages, 11 figures, accepted for publication on Review of
Scientific Instrument
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