Creatività e Cultura. Patrimoni nascosti nel settore tessile manifatturiero

A debate as to whether fashion should be considered as a creative or a cultural industry has been raging in fashion studies for several years. If we were to enter this discussion, which involves scholars of various extraction, we could say that fashion, whilst expressing the productive side of the textile and clothing sector, is “a creative and cultural industry of its own kind”. The cultural dimension and the creative dimension lead to the designing of clothes that in time will “write” a designer's story. They mark out an identity. They provide narratives of weaves, styles, colours, volumes and experimentations. They particularly reveal the dialogue between fashion designers and others involved in the process: weavers, artisans, pattern makers and embroiderers, but also chemists, engineers and mathematicians. Over time, these connections become a historical asset to be protected and enhanced.Italian fashion is created and built on the many connections between designers and companies. One interesting case is the relationship between Gianfranco Ferré and "Ricami Laura". It is a cultural and creative exchange based on knowledge and technique. It deals in drawings, letters, faxes, strips of fabric, sketches and designs. These materials now enable us to reveal the thought processes behind the style choices of one of Made in Italy's biggest designers and the masterful skill of embroiderers steeped in the Italian tradition

L’uso delle nuove tecnologie: dal virtuale al pragmatico, l’esperienza della biblioteca Luca Pacioli

New technologies have transformed the organization of Public Administration in Italy. Innovations include online services and improved communication with users. Concurrently the concept of formation has changed. Today continuing professional development is vital to ensure that the sector’s human capital remains abreast of innovative work practices and technologies. Libraries are adapting their services to an ever evolving environment, taking on the challenges of the information revolution. The Luca Pacioli Library derwent radical change, eliminating open shelving in 2006. Its adaptive strategies have succeeded in inspiring reading and knowledge creation, and its continuing growth demonstrates its importance in this context. Despite the space reduction and loss of open shelving, thanks to the automated robotic retrieval system, interactive catalog, e-learning platform and elegant space, readers’ information seeking journeys pass from the tangible to the virtual and vice versa. Users have participated enthusiastically in the initiative which asks them to write a review of the book they have borrowed. Published on the e-learning platform, these reviews demonstrate continual commitment to and appreciation of language use.L’avvento delle nuove tecnologie ha trasformato l’organizzazione della Pubblica Amministrazione anche in Italia che si è rinnovata offrendo servizi on-line e ha migliorato la comunicazione con l’utenza. Allo stesso tempo anche il concetto di formazione è mutato e oggi si parla di formazione continua necessaria per rimanere sempre aggiornati. Anche le biblioteche si adeguano a questi cambiamenti e alle sfide di questa nuova rivoluzione industriale. In questo scenario in mutazione si descrive l’esperienza della Biblioteca Luca Pacioli che subisce nel 2006 un cambiamento radicale e nonostante questo riesce con adeguate strategie a stimolare la lettura e l’uso della lingua e a rimanere un organismo in crescita. La biblioteca, pur vedendo la riduzione del suo spazio logistico e la perdita dello scaffale aperto, riesce mediante un magazzino robotizzato, un catalogo interattivo, una piattaforma di e-learning, un ambiente elegante a essere competitiva offrendo ai suoi lettori un percorso che partendo dal tangibile diventa virtuale e viceversa. L’invito ai suoi utenti di prendere in prestito un volume e a scrivere una recensione è ben accolto dai suoi lettori che accolgono l’iniziativa in maniera positiva. Le recensioni pervenute sono pubblicate sulla piattaforma di e-learning. È questa una forma di rinascita e apprezzamento dell’uso della lingua

Exploring hematic crasis variations in cancer patients following SARS-CoV-2 vaccination: a real-practice study

: SARS-CoV-2 vaccination is strongly recommended, particularly for fragile patients such as those undergoing active oncological treatments. It is crucial to conduct post-marketing surveillance in this patient population. In our study, we conducted a retrospective analysis of real-world data, including 136 patients who received SARS-CoV-2 vaccines and were undergoing anticancer treatments between March 1st and June 30th, 2021. All patients received mRNA vaccines, namely Pfizer-BioNTech's COMIRNATY (BNT162b2 mRNA) and Moderna's mRNA-1273 COVID-19 vaccines. We collected blood samples from the patients one week to 10 days before and after vaccine administration to assess full blood count with white cell differentials. Additionally, we monitored serology titers to detect any previous SARS-CoV-2 infection before hospital admission and tracked changes over time. Our findings revealed a significant occurrence of leukopenia following both the first and second vaccine doses among patients receiving chemotherapy and chemo-immunotherapy. Importantly, this effect was independent of demographic factors such as sex, age, and Body Mass Index. In the chemo-immunotherapy treated group, we observed that concomitant immune-mediated diseases were significantly associated with leukopenia following the second vaccine dose. Notably, in healthy subjects, transient neutropenia was recognized as an adverse event following vaccination. The observed lymphocytopenia during SARS-CoV-2 infection, combined with the impact on leukocyte counts observed in our study, underscores the need for larger post-marketing surveillance studies. Despite a treatment delay occurring in 6.6% of patients, the administration of mRNA vaccines did not have a significant impact on the treatment schedule in our series. These findings from a real-world setting provide valuable insights and suggest avenues for further prospective studies to explore potential complex interactions specific to this patient population

Tie2 Expressing Monocytes in the Spleen of Patients with Primary Myelofibrosis

<div><p>Primary myelofibrosis (PMF) is a Philadelphia-negative (Ph−) myeloproliferative disorder, showing abnormal CD34⁺ progenitor cell trafficking, splenomegaly, marrow fibrosis leading to extensive extramedullary haematopoiesis, and abnormal neoangiogenesis in either the bone marrow or the spleen. Monocytes expressing the angiopoietin-2 receptor (Tie2) have been shown to support abnormal angiogenic processes in solid tumors through a paracrine action that takes place in proximity to the vessels. In this study we investigated the frequency of Tie2 expressing monocytes in the spleen tissue samples of patients with PMF, and healthy subjects (CTRLs), and evaluated their possible role in favouring spleen angiogenesis. We show by confocal microscopy that in the spleen tissue of patients with PMF, but not of CTRLs, the most of the CD14⁺ cells are Tie2⁺ and are close to vessels; by flow cytometry, we found that Tie2 expressing monocytes were Tie2⁺CD14^lowCD16^brightCDL62⁻CCR2⁻ (TEMs) and their frequency was higher (p = 0.008) in spleen tissue-derived mononuclear cells (MNCs) of patients with PMF than in spleen tissue-derived MNCs from CTRLs undergoing splenectomy for abdominal trauma. By <i>in vitro</i> angiogenesis assay we evidenced that conditioned medium of immunomagnetically selected spleen tissue derived CD14⁺ cells of patients with PMF induced a denser tube like net than that of CTRLs; in addition, CD14⁺Tie2⁺ cells sorted from spleen tissue derived single cell suspension of patients with PMF show a higher expression of genes involved in angiogenesis than that found in CTRLs. Our results document the enrichment of Tie2⁺ monocytes expressing angiogenic genes in the spleen of patients with PMF, suggesting a role for these cells in starting/maintaining the pathological angiogenesis in this organ.</p></div

Evaluation of CD14⁺ cell and cell subsets in spleen derived MNCs of patients with primary myelofibrosis (PMF) and of healthy subjects (CTRLs).

<p>Data are shown as median (range).</p

<i>In vitro</i> tubulogenesis induced by spleen MNC or selected CD14⁺ cell CM.

<p>Digital images of endothelial tubes obtained by bright-field light microscopy 24 hours after plating Endothelial Colony Forming Cells from a healthy donor on Matrigel-coated wells in presence of CM of spleen tissue derived MNCs from two patients with primary myelofibrosis (PMF) and one representative CTRL (panel A), or CM of spleen tissue derived selected CD14⁺ cells from one representative patient with PMF and one CTRL (panel B). Cultures were examined under an inverted microscope (Labovert, Leitz, Germany) in bright field, at 2.5X magnification using a PL (Leitz Wetzlar, Germany) objective; quantitative evaluation of the tube-like structures, expressed as ratio of the total length of tubular structures per field (mm)/surface of the field (mm²) (ImageJ software by National Institutes of Health, USA, <a href="http://rsbweb.nih.gov/ij/" target="_blank">http://rsbweb.nih.gov/ij/</a>.), of all the patients with PMF and CTRLs tested is shown (panel C).</p