Magnetotail energy dissipation during an auroral substorm.

Violent releases of space plasma energy from the Earth's magnetotail during substorms produce strong electric currents and bright aurora. But what modulates these currents and aurora and controls dissipation of the energy released in the ionosphere? Using data from the THEMIS fleet of satellites and ground-based imagers and magnetometers, we show that plasma energy dissipation is controlled by field-aligned currents (FACs) produced and modulated during magnetotail topology change and oscillatory braking of fast plasma jets at 10-14 Earth radii in the nightside magnetosphere. FACs appear in regions where plasma sheet pressure and flux tube volume gradients are non-collinear. Faster tailward expansion of magnetotail dipolarization and subsequent slower inner plasma sheet restretching during substorm expansion and recovery phases cause faster poleward then slower equatorward movement of the substorm aurora. Anharmonic radial plasma oscillations build up displaced current filaments and are responsible for discrete longitudinal auroral arcs that move equatorward at a velocity of about 1km/s. This observed auroral activity appears sufficient to dissipate the released energy

Evidence for a flux transfer event generated by multiple X-line reconnection at the magnetopause

Magnetic flux transfer events (FTEs) are signatures of unsteady magnetic reconnection, often observed at planetary magnetopauses. Their generation mechanism, a key ingredient determining how they regulate the transfer of solar wind energy into magnetospheres, is still largely unknown. We report THEMIS spacecraft observations on 2007-06-14 of an FTE generated by multiple X-line reconnection at the dayside magnetopause. The evidence consists of (1) two oppositely-directed ion jets converging toward the FTE that was slowly moving southward, (2) the cross-section of the FTE core being elongated along the magnetopause normal, probably squeezed by the oppositely-directed jets, and (3) bidirectional field-aligned fluxes of energetic electrons in the magnetosheath, indicating reconnection on both sides of the FTE. The observations agree well with a global magnetohydrodynamic model of the FTE generation under large geomagnetic dipole tilt, which implies the efficiency of magnetic flux transport into the magnetotail being lower for larger dipole tilt

Thin Current Sheet Behind the Dipolarization Front

We report a unique conjugate observation of fast flows and associated current sheet disturbances in the near-Earth magnetotail by MMS (Magnetospheric Multiscale) and Cluster preceding a positive bay onset of a small substorm at ∼14:10 UT, September 8, 2018. MMS and Cluster were located both at X ∼ −14 RE. A dipolarization front (DF) of a localized fast flow was detected by Cluster and MMS, separated in the dawn-dusk direction by ∼4 RE, almost simultaneously. Adiabatic electron acceleration signatures revealed from the comparison of the energy spectra confirm that both spacecraft encounter the same DF. We analyzed the change in the current sheet structure based on multi-scale multi-point data analysis. The current sheet thickened during the passage of DF, yet, temporally thinned subsequently associated with another flow enhancement centered more on the dawnward side of the initial flow. MMS and Cluster observed intense perpendicular and parallel current in the off-equatorial region mainly during this interval of the current sheet thinning. Maximum field-aligned currents both at MMS and Cluster are directed tailward. Detailed analysis of MMS data showed that the intense field-aligned currents consisted of multiple small-scale intense current layers accompanied by enhanced Hall-currents in the dawn-dusk flow-shear region. We suggest that the current sheet thinning is related to the flow bouncing process and/or to the expansion/activation of reconnection. Based on these mesoscale and small-scale multipoint observations, 3D evolution of the flow and current-sheet disturbances was inferred preceding the development of a substorm current wedge

Mutant Huntingtin induces activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3)

Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive neuronal death in the basal ganglia and cortex. Although increasing evidence supports a pivotal role of mitochondrial dysfunction in the death of patients' neurons, the molecular bases for mitochondrial impairment have not been elucidated. We provide the first evidence of an abnormal activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein 3 (BNip3) in cells expressing mutant Huntingtin. In this study, we show an abnormal accumulation and dimerization of BNip3 in the mitochondria extracted from human HD muscle cells, HD model cell cultures and brain tissues from HD model mice. Importantly, we have shown that blocking BNip3 expression and dimerization restores normal mitochondrial potential in human HD muscle cells. Our data shed light on the molecular mechanisms underlying mitochondrial dysfunction in HD and point to BNip3 as a new potential target for neuroprotective therapy in HD

Boundary layer plasma flows from high-latitude reconnection in the summer hemisphere for northward IMF: THEMIS multi-point observations

On 2008-07-11, the THEMIS spacecraft, separated both longitudinally and radially, traversed the dayside low-latitude boundary layer (LLBL) under extended northward IMF. They detected southward flows of magnetosheath plasma from magnetopause reconnection poleward of the northern cusp, which were cold-dense, and had southward velocity similar to 100 km/s and longitudinal extent >3 R-E. These features all agree with a global MHD simulation of the magnetosphere for similar conditions, in which under large geomagnetic dipole tilt, an LLBL forms via poleward-of-the-cusp reconnection first in the summer hemisphere and later in the other. Contrary to the simulation, however, the observed LLBL was mostly magnetically closed, characterized by balanced field-aligned and anti-field-aligned electron fluxes, and was less thick (<= 0.5 R-E). The former suggests comparable reconnection rate in both hemispheres, while the latter suggests the actual reconnection rate being lower, and/or the plasma transport toward the magnetotail being faster, than in the simulation. Citation: Hasegawa, H., et al. (2009), Boundary layer plasma flows from high-latitude reconnection in the summer hemisphere for northward IMF: THEMIS multi-point observations, Geophys. Res. Lett., 36, L15107, doi: 10.1029/2009GL039410

A diagnosis of the plasma waves responsible for the explosive energy release of substorm onset

During geomagnetic substorms, stored magnetic and plasma thermal energies are explosively converted into plasma kinetic energy. This rapid reconfiguration of Earth’s nightside magnetosphere is manifest in the ionosphere as an auroral display that fills the sky. Progress in understanding of how substorms are initiated is hindered by a lack of quantitative analysis of the single consistent feature of onset; the rapid brightening and structuring of the most equatorward arc in the ionosphere. Here, we exploit state-of-the-art auroral measurements to construct an observational dispersion relation of waves during substorm onset. Further, we use kinetic theory of high-beta plasma to demonstrate that the shear Alfven wave dispersion relation bears remarkable similarity to the auroral dispersion relation. In contrast to prevailing theories of substorm initiation, we demonstrate that auroral beads seen during the majority of substorm onsets are likely the signature of kinetic Alfven waves driven unstable in the high-beta magnetotail

A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction

Background: Carbohydrates play a major role in cell signaling in many biological processes. We have developed a set of glycomimetic drugs that mimic the structure of carbohydrates and represent a novel source of therapeutics for endothelial dysfunction, a key initiating factor in cardiovascular complications. Purpose: Our objective was to determine the protective effects of small molecule glycomimetics against free fatty acid­induced endothelial dysfunction, focusing on nitric oxide (NO) and oxidative stress pathways. Methods: Four glycomimetics were synthesized by the stepwise transformation of 2,5­dihydroxybenzoic acid to a range of 2,5­substituted benzoic acid derivatives, incorporating the key sulfate groups to mimic the interactions of heparan sulfate. Endothelial function was assessed using acetylcholine­induced, endotheliumdependent relaxation in mouse thoracic aortic rings using wire myography. Human umbilical vein endothelial cell (HUVEC) behavior was evaluated in the presence or absence of the free fatty acid, palmitate, with or without glycomimetics (1µM). DAF­2 and H2DCF­DA assays were used to determine nitric oxide (NO) and reactive oxygen species (ROS) production, respectively. Lipid peroxidation colorimetric and antioxidant enzyme activity assays were also carried out. RT­PCR and western blotting were utilized to measure Akt, eNOS, Nrf­2, NQO­1 and HO­1 expression. Results: Ex vivo endothelium­dependent relaxation was significantly improved by the glycomimetics under palmitate­induced oxidative stress. In vitro studies showed that the glycomimetics protected HUVECs against the palmitate­induced oxidative stress and enhanced NO production. We demonstrate that the protective effects of pre­incubation with glycomimetics occurred via upregulation of Akt/eNOS signaling, activation of the Nrf2/ARE pathway, and suppression of ROS­induced lipid peroxidation. Conclusion: We have developed a novel set of small molecule glycomimetics that protect against free fatty acidinduced endothelial dysfunction and thus, represent a new category of therapeutic drugs to target endothelial damage, the first line of defense against cardiovascular disease