54 research outputs found
N-[(2-HydrÂoxy-1-naphthyl)(3-nitroÂphenyl)methÂyl]acetamide
The title compound, C19H16N2O4, is of interÂest as a precursor to biologically active substituted quinolines and related compounds. The dihedral angle between the naphthalene ring system and the benzene ring is 81.9 (1)°. The crystal structure is stabilized by N—H⋯O interÂmolecular hydrogen bonds, linking the molÂecules into pairs around a center of symmetry. The crystal structure is further stabilized by interÂmolecular O—H⋯O hydrogen bonds, which link the molÂecules into chains running along a axis. An intraÂmolecular C—H⋯O short contact is also present
Premature Centromere Division and Spontaneous Abortion
Premature Centromere Division (PCD) was observed in the chromosomes of metaphase spreads in a patient with the history of recurrent abortions. Short term leukocyte cultures were set up with blood sample from the woman with a history of recurrent abortions for the past four consequent years. 25 % of the metaphase spreads screened displayed premature centromere division of the chromosomes in each of the cells. This abnormal behavior of the centromeres may predispose the individual to cell division errors due to chromosome instability and the consequences of which may be a spontaneous abortion
[1-(3-NitroÂphenÂyl)-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazin-3-ylidine]malonaldehyde
The oxazine ring in the title compound, C21H14N2O5, adopts a flattened boat conformation. The nitroÂphenyl ring and the naphthalene ring system enclose a dihedral angle of 89.2 (1)°. An intraÂmolecular hydrogen bond is formed between the NH group and one of the adjacent carbonyl O atoms. In addition, the NH group forms an interÂmolecular hydrogen bond to a symmetry equivalent of this carbonyl O atom, connecting the molÂecules into centrosymmetric dimers. The structure also contains C—H⋯O interÂmolecular interÂactions
N-[(2-HydrÂoxy-5-methoxyÂphenÂyl)(3-nitroÂphenÂyl)methÂyl]acetamide
In the title compound, C16H16N2O5, the methÂoxy group is disordered with site occupancies of 0.20 (3) and 0.80 (3). The dihedral angle between the two aromatic rings is 73.7 (2)°. The crystal structure is characterized by intermolecular N—H⋯O, O—H⋯O, C—H⋯O and C—H⋯π hydrogen bonds
N-[(2-HydrÂoxy-1-naphthÂyl)(2-hydroxyÂphenÂyl)methÂyl]acetamide
In the asymmetric unit of the title compound, C19H17NO3, there are two crystallographically independent molÂecules, which are connected to each other by O—H⋯O hydrogen bonds, forming molÂecular chains as well as cyclic centrosymmetric R
2
2(16) dimers
High Performance Regulation at Wide Range of Speeds
This Paper presents a simplified computer program for the simulation of CSI fed 3-Phase IM drive controlled by means of vector based V/f control method using MATLAB/SIMULINK simulation software. The main features of this type of simulation program are simplicity, accuracy and efficiency in terms of computation time. This simulation program can be used to verify the system design, to study system dynamic behavior and to investigate steady state waveforms of the drive system. The feasibility, reliability of the system and the validity of the control method are proved by the simulation results. The CSI drive has so many features compared to VSI drives. In addition, symmetrical GTO, when used as switching device in the CSI, makes the drive particularly suitable for implementation at medium high voltage (4160V and up) levels and also can be useful for wide range of speed control applications(from below to above rated speed)
Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is primarily diagnosed in the latter stages of disease progression and is the third leading cause of cancer deaths worldwide. Thus, there is a need to find biomarkers of early HCC as well as the development of more effective treatments for the disease. Sphingosine-1-phosphate (S1P) is a pleiotropic lipid signaling molecule produced by two isoforms of sphingosine kinase (SphK1 and SphK2) that is involved in regulation of many aspects of mammalian physiology and pathophysiology, including inflammation, epithelial and endothelial barrier function, cancer, and metastasis, among many others. Abundant evidence indicates that SphK1 and S1P promote cancer progression and metastasis in multiple types of cancers. However, the role of SphK/S1P in HCC is less well studied. Here, we review the current state of knowledge of SphKs and S1P in HCC, including evidence for the correlation of SphK1 expression and S1P levels with progression of HCC and negative outcomes, and discuss how this information could lead to the design of more effective diagnostic and treatment modalities for HCC
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