64 research outputs found
Effects of surface heterogeneity of carbon nanotubes in adsorption of colloid nanoparticles studied by means of computer simulations
A Comprehensive Investigation on Common Polymorphisms in the MDR1/ABCB1 Transporter Gene and Susceptibility to Colorectal Cancer
ATP Binding Cassette B1 (ABCB1) is a transporter with a broad substrate specificity involved in the elimination of several carcinogens from the gut. Several polymorphic variants within the ABCB1 gene have been reported as modulators of ABCB1-mediated transport. We investigated the impact of ABCB1 genetic variants on colorectal cancer (CRC) risk. A hybrid tagging/functional approach was performed to select 28 single nucleotide polymorphisms (SNPs) that were genotyped in 1,321 Czech subjects, 699 CRC cases and 622 controls. In addition, six potentially functional SNPs were genotyped in 3,662 German subjects, 1,809 cases and 1,853 controls from the DACHS study. We found that three functional SNPs (rs1202168, rs1045642 and rs868755) were associated with CRC risk in the German population. Carriers of the rs1202168_T and rs868755_T alleles had an increased risk for CRC (Ptrend = 0.016 and 0.029, respectively), while individuals bearing the rs1045642_C allele showed a decreased risk of CRC (Ptrend = 0.022). We sought to replicate the most significant results in an independent case-control study of 3,803 subjects, 2,169 cases and 1,634 controls carried out in the North of Germany. None of the SNPs tested were significantly associated with CRC risk in the replication study. In conclusion, in this study of about 8,800 individuals we show that ABCB1 gene polymorphisms play at best a minor role in the susceptibility to CRC
Role of intermolecular interactions in assemblies of nanocontainers composed of carbon nanotubes and magnetic nanoparticles: A molecular dynamics study
10.1021/jp410736sJournal of Physical Chemistry C11821353-136
Molecular dynamics study of cisplatin release from carbon nanotubes capped by magnetic nanoparticles
10.1021/jp405593uJournal of Physical Chemistry C1173317327-1733
Non-spherical particles for optical trap assisted nanopatterning Non-spherical particles for optical trap assisted nanopatterning
Abstract Optical trap assisted nanopatterning is a laser direct-write technique that uses an optically trapped microsphere as a near-field objective. The type of feature that one can create with this technique depends on several factors, one of which is the shape of the microbead. In this paper, we examine how the geometry of the bead affects the focus of the light through a combination of experiments and simulations. We realize nanopatterning using non-spherical dielectric particles to shape the light-material interaction. We model the resulting nanoscale features with a finite difference time domain simulation and obtain very good agreement with the experiments. This work opens the way to systematic engineering of the microparticle geometry in order to tailor the near-field focus to specific nanopatterning applications
Sidewall Functionalization of Carbon Nanotubes as a Method of Controlling Structural Transformations of the Magnetically Triggered Nanocontainer: A Molecular Dynamics Study
Comparative Analysis of Nitrogen Adsorption Kinetics on Fe(100) and Fe(111) Based on Applying the Statistical Rate Theory
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