Impacts of Future Climate Change on Net Primary Productivity of Grassland in Inner Mongolia, China

Net Primary Productivity (NPP) of grassland is a key variable of terrestrial ecosystems and is an important parameter for characterizing carbon cycles in grassland ecosystems. In this research, the Inner Mongolia grassland NPP was calculated using the Miami Model and the impact of climate change on grassland NPP was subsequently analyzed under the Special Report on Emissions Scenarios (SRES) A2, B2, and A1B scenarios, which are inferred from Providing Regional Climates for Impacts Studies (PRECIS) climate model system. The results showed that: (1) the NPP associated with these three scenarios had a similar distribution in Inner Mongolia: the grassland NPP increased gradually from the western region, with less than 200 g/m2/yr, to the southeast region, with more than 800 g/m2/yr. Precipitation was the main factor determining the grassland NPP; (2) compared with the baseline (1961-1990), there would be an overall increase in grassland NPP during three time periods (2020s: 2011-2040, 2050s: 2041-2070, and 2080s: 2071-2100) under the A2 and B2 scenarios; (3) under the A1B scenario, there will be a decreasing trend at middle-west region during the 2020s and 2050s; while there will be a very significant decrease from the 2050s to 2080s for middle Inner Mongolia; and (4) grassland NPP under the A1B scenario would present the most significant increase among the three scenarios, and would have the least significant increase under the B2 scenario

Matrine inhibits hepatocellular carcinoma cell malignancy through the circ_0013290/miR-139-5p/MMP16 pathway

Background. Previous studies have shown the anticancer effect of Matrine on hepatocellular carcinoma (HCC); however, the underlying mechanism is still indistinct. Methods. The expression of circular RNA_0013290 (circ_0013290), microRNA-139-5p (miR-139-5p), matrix metallopeptidase 16 (MMP16), CyclinD1 and N-cadherin was analyzed by quantitative real-time polymerase chain reaction, Western blotting or immuno-histochemistry assay. Cell viability, proliferation, apoptosis, invasion and tube formation were analyzed by cell counting kit-8, 5-Ethynyl-2’-deoxyuridine, flow cytometry analysis, transwell invasion and tube formation assays, respectively. The associations among circ_0013290, miR-139-5p and MMP16 were predicted by starbase online database, and identified by dual-luciferase reporter and RNA pull-down assays. A xenograft mouse model assay was conducted to disclose the effects of circ_0013290 and Matrine on tumor tumorigenesis in vivo. Results. Circ_0013290 and MMP16 expression were significantly upregulated, while miR-139-5p was downregulated in HCC tissues and cells compared with the matched normal liver tissues and cells. Matrine treatment inhibited HCC cell proliferation, invasion and tube formation but induced cell apoptosis, accompanied by the decrease of CyclinD1 and N-cadherin expression; however, these effects were counteracted when circ_0013290 expression was increased. MiR-139-5p depletion or MMP16 introduction relieved Matrine-induced effects in HCC cells. The regulation of circ_0013290 toward HCC cell processes involved MMP16. With respect to the mechanism, circ_0013290 acted as a miR-139-5p sponge, and miR-139-5p targeted MMP16 in HCC cells. Besides, circ_0013290 regulated MMP16 expression through miR-139-5p. Further, circ_0013290 depletion enhanced the inhibitory effects of Matrine on tumor tumorigenesis. Conclusion. Matrine inhibited HCC cell malignancy through the circ_0013290/miR-139-5p/MMP16 pathway, suggesting that Matrine is a potential therapeutic agent for HC

Agriculture intensifies soil moisture decline in Northern China

Northern China is one of the most densely populated regions in the world. Agricultural activities have intensified since the 1980s to provide food security to the country. However, this intensification has likely contributed to an increasing scarcity in water resources, which may in turn be endangering food security. Based on in-situ measurements of soil moisture collected in agricultural plots during 1983–2012, we find that topsoil (0–50cm) volumetric water content during the growing season has declined significantly (p < 0.01), with a trend of −0.011 to −0.015 m3 m−3 per decade. Observed discharge declines for the three large river basins are consistent with the effects of agricultural intensification, although other factors (e.g. dam constructions) likely have contributed to these trends. Practices like fertilizer application have favoured biomass growth and increased transpiration rates, thus reducing available soil water. In addition, the rapid proliferation of water-expensive crops (e.g., maize) and the expansion of the area dedicated to food production have also contributed to soil drying. Adoption of alternative agricultural practices that can meet the immediate food demand without compromising future water resources seem critical for the sustainability of the food production system

Energy-efficient multiuser and multitask computation offloading optimization method

For dynamic application scenarios of Mobile Edge Computing (MEC), an Energy-efficient Multiuser and Multitask Computation Offloading (EMMCO) optimization method is proposed. Under the consideration of multiuser and multitask computation offloading, first, the EMMCO method takes into account the existence of dependencies among different tasks within an implementation, abstracts these dependencies as a Directed Acyclic Graph (DAG), and models the computation offloading problem as a Markov decision process. Subsequently, the task embedding sequence in the DAG is fed to the RNN encoder-decoder neural network with combination of the attention mechanism, the long-term dependencies among different tasks are successfully captured by this scheme. Finally, the Improved Policy Loss Clip-based PPO2 (IPLC-PPO2) algorithm is developed, and the RNN encoder-decoder neural network is trained by the developed algorithm. The loss function in the IPLC-PPO2 algorithm is utilized as a preference for the training process, and the neural network parameters are continuously updated to select the optimal offloading scheduling decisions. Simulation results demonstrate that the proposed EMMCO method can achieve lower latency, reduce energy consumption, and obtain a significant improvement in the Quality of Service (QoS) than the compared algorithms under different situations of mobile edge network