Integrated Design Approach to Build a Safe and Sustainable Dual Intended Use Center in Praslin Island, Seychelles

A flexible multi-purpose center for a dual intended use—hospitality and observation and research related to climate change—has been designed in the fragile environment of Praslin Island, Seychelles. The technical solutions adopted for a low environmental impact LCA based in the designed center during the life cycle will be illustrated: starting from the local supply raw materials, the self-disassembling construction system, the described process is compatible with the site use that the owners have foreseen. Specific logistic systems have been chosen both to the transportation of the material on the site, and to the integrated structural and architectural solutions. In addition, a reconstruction of the natural characteristics of the building site has been developed both by google-earth observation and with a survey directly on the site through processing acquired images. The multi-disciplinary perspective through which the project has been conceived shows beneficial effects in terms of reduced impact on the original and resilient natural environment. Future developments of the work will be devoted to the optimization of this multi-disciplinary approach

Automated power gating methodology for dataflow-based reconfigurable systems

Modern embedded systems designers are required to implement efficient multi-functional applications, over portable platforms under strong energy and resources constraints. Automatic tools may help them in challenging such a complex scenario: to develop complex reconfigurable systems while reducing time-to-market. At the same time, automated methodologies can aid them to manage power consumption. Dataflow models of computation, thanks to their modularity, turned out to be extremely useful to these purposes. In this paper, we will demonstrate as they can be used to automatically achieve power management since the earliest stage of the design flow. In particular, we are focussing on the automation of power gating. The methodology has been evaluated on an image processing use case targeting an ASIC 90 nm CMOS technology

Numerical study of the scaling properties of SU(2) lattice gauge theory in Palumbo non-compact regularization

In the framework of a non-compact lattice regularization of nonabelian gauge theories we look, in the SU(2) case, for the scaling window through the analysis of the ratio of two masses of hadronic states. In the two-dimensional parameter space of the theory we find the region where the ratio is constant, and equal to the one in the Wilson regularization. In the scaling region we calculate the lattice spacing, finding it at least 20% larger than in the Wilson case; therefore the simulated physical volume is larger.Comment: 24 pages, 7 figure

Modelling and Automated Implementation of Optimal Power Saving Strategies in Coarse-Grained Reconfigurable Architectures

This paper focuses on how to efficiently reduce power consumption in coarse-grained reconfigurable designs, to allow their effective adoption in heterogeneous architectures supporting and accelerating complex and highly variable multifunctional applications. We propose a design flow for this kind of architectures that, besides their automatic customization, is also capable of determining their optimal power management support. Power and clock gating implementation costs are estimated in advance, before their physical implementation, on the basis of the functional, technological, and architectural parameters of the baseline design. Experimental results, on 90 and 45 nm CMOS technologies, demonstrate that the proposed approach guides the designer towards optimal implementation

The epilepsy phenotype in adult patients with intellectual disability and pathogenic copy number variants

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Hyaluronic-Based Antibacterial Hydrogel Coating for Implantable Biomaterials in Orthopedics and Trauma: From Basic Research to Clinical Applications

Bacterial colonization of implanted biomaterials remains one of the most challenging complications in orthopedics and trauma surgery, with extremely high social and economic costs. Antibacterial coating of implants has been advocated by many experts as a possible solution to reduce the burden of implant-related infection and several different solutions have been proposed in the last decades. However, while most of the investigated technologies have shown their efficacy in vitro and/or in vivo, only few were able to reach the market, due to clinical, industrial, economic and regulatory issues. Hyaluronic acid composites have been previously shown to possess antifouling capabilities and have been used in various clinical settings to reduce bacterial adhesion and mitigate biofilm-related infections. Recently, a fast-resorbable, hyaluronic-based hydrogel coating was developed to protect implanted biomaterials in orthopedics, trauma and maxillofacial surgery. Preclinical and clinical testing did show the safety and efficacy of the device that can be intraoperatively loaded with one or more antibiotics and directly applied by the surgeon to the implant surface, at the time of surgery. Here, we review the current evidence concerning this very first antibacterial coating of implants and outline the economic impact of the possible large-scale application of this technology

Magnetic resonance-guided focused ultrasound surgery treatment of non-spinal intra-articular osteoblastoma: feasibility, safety, and outcomes in a single-center retrospective analysis

Background: Interventional radiology, thanks to its low invasiveness and possibility to reduce the average time for the patients to come back to their normal activity, is becoming more and more promising and diffused in multiple fields. Employed without needles, MRgFUS is probably the less invasive techniques among the ones belonging to the field of interventional radiology. Purpose: To evaluate safety and effectiveness of MRgFUS in the treatment of a rare and benign, though disabling, bone lesion: intra-articular osteoblastoma. Materials and methods: A retrospective study was carried out on 6 patients (mean, 21 years) treated in the last 2 years with MRgFUS for symptomatic, histologically proved intra-articular osteoblastoma. The main inclusion criterion was the presence of a good acoustic window. The procedures consisted in MR-guided ablation, using high intensity ultrasound beams focused on the target lesion. Spinal anesthesia or peripheral nerve block was used. Clinical (based on pain and functional scales) and imaging follow-up studies were performed up to 1 year after treatment. Complications were recorded. Multiple linear regression and analysis of variance were used to assess correlations. Results: All the procedures were technically successful; no complications were observed. Painful symptomatology decreased of 88% at 6 months and 98% at 12 months (p < 0.0001), and was associated to functional improvement (p = 0.002). MRI and CT controls showed disappearance of all signs of disease and bone inflammation with a marked tendency to bone healing. Conclusion: This study shows the safety and effectiveness of MRgFUS in the treatment of intra-articular osteoblastoma with a good acoustic window