Urban and Transport Scaling: Northern Mesopotamia in the Late Chalcolithic and Bronze Age

Scaling methods have been applied to study modern urban areas and how they create accelerated, feedback growth in some systems while efficient use in others. For ancient cities, results have shown that cities act as social reactors that lead to positive feedback growth in socioeconomic measures. In this paper, we assess the relationship between settlement area expressed through mound area from Late Chalcolithic and Bronze Age sites and mean hollow way widths, which are remains of roadways, from the Khabur Triangle in northern Mesopotamia. The intent is to demonstrate the type of scaling and relationship present between sites and hollow ways, where both feature types are relatively well preserved. For modern roadway systems, efficiency in growth relative to population growth suggests roads should show sublinear scaling in relation to site size. In fact, similar to modern systems, such sublinear scaling results are demonstrated for the Khabur Triangle using available data, suggesting ancient efficiency in intensive transport growth relative to population levels. Comparable results are also achieved in other ancient Near East regions. Furthermore, results suggest that there could be a general pattern relevant for some small sites (0–2 ha) and those that have fewer hollow ways, where β, a measure of scaling, is on average low (≈ < 0.2). On the other hand, a second type of result for sites with many hollow ways (11 or more) and that are often larger suggests that β is greater (0.23–0.72), but still sublinear. This result could reflect the scale in which larger settlements acted as greater social attractors or had more intensive economic activity relative to smaller sites. The provided models also allow estimations of past roadway widths in regions where hollow ways are missing

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

Commercial Landscapes of Long-distance Contacts in Western Asia, c. 3200 – 1600 BC: Perspectives from Material Culture

To our knowledge, this dataset represents the largest existing repository of archaeological material culture data for Anatolia, northern Mesopotamia, and northern Levant during the Early and Middle Bronze Age (ca. 3,200 – 1,600 BC). Here we present four types of objects (lapis lazuli and ivory artefacts, Syrian bottles, and balance pan weights) that can be analysed as tracers of long-distance contacts for assessing what exchange patterns and socio-economic dynamics (e.g. gifts, trade, marriage alliances, tribute, market profit, reciprocity, etc.) are responsible for the allocation and distribution of these materials in the Near East

Change and continuity in the long-distance exchange networks between western/central Anatolia, northern Levant and northern Mesopotamia, c.3200–1600 BCE

This paper investigates and offers explanations for the distribution of specific products (ivory and lapis lazuli artefacts, “Syrian” bottles) and technologies (metrology) that have often been invoked as tracers of long-distance trade contacts and/or political units in Anatolia, northern Levant and northern Mesopotamia during the Early and Middle Bronze Ages. Unlike former studies investigating third and second millennia exchange networks as separate entities, we examine comparatively and systematically a large corpus of published archaeological data by adopting a quantitative and spatial approach. Through this analysis, we propose that a significant degree of similarity in the shape, infrastructure and motivations behind the development and maintenance of these long-distance exchanges existed between the third and early second millennia BC

Measuring the divergence of laser beams to correct interferometric displacement measurements

Owing to the impossibility of a plane-wave illumination, diffraction affects optical interferometry applied to the measuring of linear displacement. Therefore, the measurement of the beam divergence is essential to calculate the needed corrections. This paper examines a measurement method relying on the Fourier optics. Particular emphasis is given to the assessment of systematic errors in the measurement of the Si lattice parameter by combined X-ray and optical interferometry