Visualizing Processes on the Web

In this paper, we describe 3WPS, a framework to build distributed systems that are able to monitor and interact with a process through a 3D interface that is accessible via the World Wide Web (WWW). The 3WPS is easily configurable, easily adaptable to different processes with high reuse of ts software components and its distributed architecture leverages on off-the-shelf components of the WWW infrastructure such as Java applets and Virtual Reality Modeling Language (VRML) browsers. We describe the characteristics of 3WPS framework by mainly focusing on the issue of programmability and by contextually providing an example tour of its usage

Peliosis hepatis. Personal experience and literature review

Peliosis hepatis (PH) is a disease characterized by multiple and small, blood-filled cysts within the parenchymatous organs. PH is a very rare disease, more common in adults, and when it affects the liver, it comes to the surgeon’s attention only in an extremely urgent situation after the lesion’s rupture with the resulting hemoperitoneum. This report describes the case of a 29-year-old woman affected by recurring abdominal pain. CT scans showed a hepatic lesion formed by multiple hypodense areas, which showed an early acquisition of the contrast during the arterial phase. Furthermore, it remained isodense with the remaining parenchyma during the late venous phase. We decided on performing a liver resection of segment Ⅶ while avoiding a biopsy for safety reasons. The histopathologic examination confirmed the diagnosis of focal PH. PH should always be considered in the differential diagnosis of hepatic lesions. Clinicians should discuss the possible causes and issues related to the differential diagnosis in addition to the appropriate therapeutic approach. The fortuitous finding of a lesion, potentially compatible with PH, requires elective surgery with diagnostic and therapeutic intents. The main aim is to prevent the risk of a sudden bleeding that, in absence of properly equipped structures, may have a fatal outcome

Pulsology Reloaded

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Patients’ self-evaluation of symptoms, signs and compliance to therapy for heart failure surveillance: A pilot study on identification of worsening heart failure

In patients with chronic heart failure (HF), it is unclear whether self-evaluation of HF-related symptoms and signs may contribute to the surveillance of clinical stability over time or the early identification of worsening HF.   Therefore, HF-related symptoms and signs, and compliance to therapy were investigated by a self-administrated questionnaire in patients hospitalized due to worsening HF (cases) as well in those with stable HF (controls).  The temporal interval of interest for the questionnaire focused on 2 to 7 days before the hospitalization of the control visit.  A method called “classic” extrapolated a surveillance score by 4 questions revealing HF-related symptoms or signs (higher score indicative of more symptoms or sings reported).  Alternatively, 3 additional questions enriched the “classic” questionnaire, including one on whether the health status was perceived as stable, improved or worsening.  The score from “perceived health status”  inquiry was used as “conditional factor” to computed the surveillance score as: conditional factor + [conditional factor X (the sum of the points yielded by the responses to each question on symptoms, sings and compliance to therapy)].  Among 51 patients hospitalized due to worsening HF and 104 with chronic HF (retrospective study), the area under the curve (receiver operating characteristic) discriminating worsening HF was 0.90 by the classic, and 0.96 by the conditional method (both p<0.001), yielding error rates of 2 in 10 by the classic and 1 in 10 by the conditional method.  In a pilot longitudinal study in 37 ambulatory HF patients from a different population source, predicting worsening HF by alternative questionnaires within 12 weeks from the visit yielded consistent results.  In conclusion, patients’ self-monitoring symptoms, signs and compliance by a standardized questionnaire and a conditional method for generating relative a score, may be a promising method for HF stability surveillance

Does the mixing length parameter depend on metallicity?

This paper is a further step in the investigation of the morphology of the color-magnitude diagram of Galactic globular clusters, and the fine-tuning of theoretical models, made possible by the recent observational efforts to build homogeneous photometric databases. In particular, we examine here the calibration of the morphological parameter W(HB) vs. metallicity, originally proposed by Brocato et al. (1998), which essentially measures the color position of the red-giant branch. We show that the parameter can be used to have a first-order estimate of the cluster metallicity, since the dispersion around the mean trend with [Fe/H] is compatible with the measurement errors. The tight W(HB)-[Fe/H] relation is then used to show that variations in helium content or age do not affect the parameter, whereas it is strongly influenced by the mixing-length parameter alpha (as expected). This fact allows us, for the first time, to state that there is no trend of alpha with the metal content of a cluster. A thorough examination of the interrelated questions of the alpha-elements enhancement and the color-T(eff) transformations, highlights that there is an urgent need for an independent assessment of which of the two presently accepted metallicity scales is the true indicator of a cluster's iron content. Whatever scenario is adopted, it also appears that a deep revision of the (V-I)-temperature relations is needed.Comment: 15 pages, 21 figures, accepted by A&

Introducing Collaboration in Single-user Applications through the Centralized Control Architecture

In this paper we describe a novel Model-View­ Controller based architecture, Centralized Control, that intro­duces collaboration in single-users applications. The architecture is able to add collaboration with no need to modify the source code of the original single-user application, and providing also the capability to introduce group semantics into the new, collab­orative application that is obtained. The architecture is shown in practice, by introducing CollabXMind, a collaborative mind map tool, that is based on a well-known single-user tool, XMind

Would You Prescribe Mobile Health Apps for Heart Failure Self-care? An Integrated Review of Commercially Available Mobile Technology for Heart Failure Patients

Treatment of chronic diseases, such as heart failure, requires complex protocols based on early diagnosis; self-monitoring of symptoms, vital signs and physical activity; regular medication intake; and education of patients and caregivers about relevant aspects of the disease. Smartphones and mobile health applications could be very helpful in improving the efficacy of such protocols, but several barriers make it difficult to fully exploit their technological potential and produce clear clinical evidence of their effectiveness. App suppliers do not help users distinguish between useless/dangerous apps and valid solutions. The latter are few and often characterised by rapid obsolescence, lack of interactivity and lack of authoritative information. Systematic reviews can help physicians and researchers find and assess the 'best candidate solutions' in a repeatable manner and pave the way for well-grounded and fruitful discussion on their clinical effectiveness. To this purpose, the authors assess 10 apps for heart failure self-care using the Intercontinental Marketing Statistics score and other criteria, discuss the clinical effectiveness of existing solutions and identify barriers to their use in practice and drivers for change

Novelette, a Usable Visual Storytelling Digital Learning Environment

Educational digital storytelling is widely recognised as a powerful approach in developing literary skills, experiencing problem-solving and computational thinking, information and knowledge visualisation, building creativity and divergent thinking supported by technological solutions. However, educators feel that they miss opportunities, skills, and tools to support pupils developing creativity. Hence, we proposed a digital learning environment, named Novelette, to support both educators and learners in performing visual storytelling by scaffolding them in inventing and authoring stories. The main novelty of our approach lies in embedding literary artifices widely explored in learning settings into a digital learning environment, such as the opportunity to continue someone else’s story and the suggestion mechanism to explore analogies or synonyms starting from a word of interest. Novelette has been ideated not only as a learning environment for educators, but with educators, as it results from a user-centered and participatory design methodology to involve them in the entire design and development process actively. This paper focuses on the assessment of Novelette usability according to both educators and pupils. As a conclusive step of the co-design approach, developers tested the resulting usability according to educators in a controlled environment. Moreover, it reports usability according to learners in real settings at school. Results demonstrate that Novelette is considered usable by both target groups, and it is perceived as a powerful approach in developing creativity both according to quantitative insight offered by the System Usability Scale, a.k.a., SUS, and qualitative interpretations enabled with direct observations and structured after scenario questionnaires. We can conclude that Novelette is a pleasant and usable tool to invent and author stories and seems to be a promising approach to develop creativity

The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis

<p>Abstract</p> <p>Background</p> <p>We previously showed that mice lacking the high mobility group A1 gene (<it>Hmga1</it>-knockout mice) developed a type 2-like diabetic phenotype, in which cell-surface insulin receptors were dramatically reduced (below 10% of those in the controls) in the major targets of insulin action, and glucose intolerance was associated with increased peripheral insulin sensitivity. This particular phenotype supports the existence of compensatory mechanisms of insulin resistance that promote glucose uptake and disposal in peripheral tissues by either insulin-dependent or insulin-independent mechanisms. We explored the role of these mechanisms in the regulation of glucose homeostasis by studying the <it>Hmga1</it>-knockout mouse model. Also, the hypothesis that increased insulin sensitivity in <it>Hmga1</it>-deficient mice could be related to the deficit of an insulin resistance factor is discussed.</p> <p>Results</p> <p>We first show that HMGA1 is needed for basal and cAMP-induced retinol-binding protein 4 (<it>RBP4</it>) gene and protein expression in living cells of both human and mouse origin. Then, by employing the <it>Hmga1</it>-knockout mouse model, we provide evidence for the identification of a novel biochemical pathway involving HMGA1 and the RBP4, whose activation by the cAMP-signaling pathway may play an essential role for maintaining glucose metabolism homeostasis <it>in vivo</it>, in certain adverse metabolic conditions in which insulin action is precluded. In comparative studies of normal and mutant mice, glucagon administration caused a considerable upregulation of HMGA1 and RBP4 expression both at the mRNA and protein level in wild-type animals. Conversely, in <it>Hmga1</it>-knockout mice, basal and glucagon-mediated expression of RBP4 was severely attenuated and correlated inversely with increased <it>Glut4 </it>mRNA and protein abundance in skeletal muscle and fat, in which the activation state of the protein kinase Akt, an important downstream mediator of the metabolic effects of insulin on Glut4 translocation and carbohydrate metabolism, was simultaneously increased.</p> <p>Conclusion</p> <p>These results indicate that HMGA1 is an important modulator of <it>RBP4 </it>gene expression <it>in vivo</it>. Further, they provide evidence for the identification of a novel biochemical pathway involving the cAMP-HMGA1-RBP4 system, whose activation may play a role in glucose homeostasis in both rodents and humans. Elucidating these mechanisms has importance for both fundamental biology and therapeutic implications.</p