ANALYSIS OF THE BENEFITS OF INTRA-PORT COMPETITION

Intra-port competition is widely regarded as beneficial, for the competitiveness of ports, for local and national economies and for consumers and exporting industries. The aim of the paper is to analyse the benefits resulting from the presence of intra-port competition. Even though this issue has been addressed before, a thorough and complete overview of the effects of intra-port competition, enabling conditions for intra-port competition and policies in case of lacking intra-port competition are absent. The paper presents first a short overview of previous studies dealing with intra-port competition. Second, it discusses the two main arguments underlying the benefits of intra-port competition. In this context, attention is given to the relation between intra-port and inter-port competition. Third, the paper examines the conditions under which these arguments are valid and intra-port competition can be introduced. Possible policy responses to limited or absent intra-port competition are discussed in this section as well. Fourth, the need to introduce effects of intra-port competition in port modelling is briefly. Finally, the paper presents empirical evidence of the effects of intra-port competition.ports, intra-port competition, regulation, port policies

PORT REORGANISATION AND THE WORLDS OF PRODUCTION THEORY

Taking into consideration the new dimensions of port production that have become evident during the resent past, this paper tackles the issue of port reorganisation. In the light of the changes in the world economy and the new competitive environment, the paper focuses on the new structures of the port industry and the characteristics of the contemporary port product within a more general analytical framework of ‘Worlds of Production’. This conceptualisation suggests that neither the industrial model of mass production, nor any other model alone, can determine a single effective pattern of organisation of port production. Within the new reality, modern ports must provide a greater variety of services to port users than in the past. The diversity and complexity of the contemporary port product demand the application of multiple organisational transformations incorporating elements from different possible action frameworks. In this vein, the introduction of intra-port competition, the development of strategic or regional networks, and the reconsideration of the role of port authority turn to critical parameters of the necessary restructuring.Port Industry, reorganisation, worlds of production theory

The EU port policy in a historical perspective

This paper examines the evolution of the European Union (EU) Port Policy within a historical perspective. Analysing the changing aspects of the sectoral socio-economic context and the alterations of the institutional setting, the paper explains the slow start towards a European Port Policy (EPP), that lasted more than three decades, and then assesses why, and how, policy actors involved in the EU policy making have succeeded in carving out elements of a policy framework. The study chronicles the stages by which the EU has moved into the port policy field. Grounding on the analysis of the changing sectoral environment, the paper analyses the complex sequence of events, which have led either to legislative and political decisions or to output failures. As demonstrated by the historical analysis (1957-2004), policy integration is a dynamic, seemingly irreversible, process, which marked by the searching for a balance between liberalisation and harmonisation.peer-reviewe

Maritime interests and the EU port services directive

A key theme of the EU Port Policy has been the establishment of free market access to the provision of port services in EU ports. However, two successive European Commission proposals for a relevant EU port services directive (PSD) failed to produce a new policy regime. This paper examines the mobilisation of maritime interests, aiming to identify stakeholders’ preferences and their contribution to the rejection of this port policy proposal. The analysis suggests that, although they did not share the same perspective, the views of organised maritime interests shared a common denominator: they were against the proposed EU rule due to its structural deficiencies. Assisted by the industrial heterogeneity, the difficulties to implement a ‘one size fits all ports’ policy, and the observed institutional tensions a variety of vested interests frequently with monopolistic positions contributed to the produced policy output failure

A randomized phase III study of the docetaxel/carboplatin combination versus docetaxel single-agent as second line treatment for patients with advanced/metastatic Non-Small Cell Lung Cancer

<p>Abstract</p> <p>Background</p> <p>To compare the activity and toxicity of docetaxel/carboplatin (DC) doublet vs single agent docetaxel (D) as second-line treatment in patients with advanced non-small cell lung cancer (NSCLC).</p> <p>Methods</p> <p>Patients pre-treated with front-line platinum-free regimens, were randomized to receive either docetaxel/carboplatin (DC), (docetaxel 50 mg/m²; carboplatin AUC4; both drugs administered on days 1 and 15) or docetaxel single-agent (D), (docetaxel 50 mg/m²on days 1 and 15).</p> <p>Results</p> <p>Response rate was similar between the two arms (DC vs D: 10.4% vs 7.7%; p = 0.764). After a median follow-up time of 28.0 months for DC arm and 34.5 months for D arm, progression free survival (PFS) was significantly higher in the DC arm (DC vs D:3.33 months vs 2.60 months; p-value = 0.012), while no significant difference was observed in terms of overall survival (OS) (DC vs D: 10.3 months vs 7.70 months; p-value = 0.550). Chemotherapy was well-tolerated and grade III/IV toxicities were relatively infrequent. No toxic deaths were observed.</p> <p>Conclusions</p> <p>This study has not achieved its primary objective of significant OS prolongation with docetaxel/carboplatin combination over single-agent docetaxel in patients who had not received front-line docetaxel; however, the docetaxel/carboplatin combination was associated with a significant clinical benefit in terms of PFS.</p

Assessing health-related quality of life in patients with inflammatory bowel disease, in Crete, Greece

BACKGROUND: Health Related Quality of Life (HRQoL) is an important outcome measure in Inflammatory Bowel Disease (IBD). The aim of our study was to assess HRQoL in a population of 135 Greek patients with IBD. METHODS: A cohort of 135 patients with IBD, 81 with ulcerative colitis (UC) and 54 with Crohn's disease (CD) were enrolled in our study. Demographic and disease-related data were recorded. HRQoL was assessed by a disease-specific and a generic questionnaire, IBDQ and SF-36, respectively. Disease activity was assessed by Harvey-Bradshaw Index and the Colitis Activity Index for CD and UC patients, respectively. RESULTS: Among all variables recorded in our study, only disease activity had a significant effect on HRQoL. Patients with active disease scored significantly lower on both IBDQ and SF-36 when compared to those in remission. Only two among the four IBDQ dimensions, bowel and systemic, had significant ability in distinguishing best patients in remission from those with active disease. CONCLUSIONS: IBD has a negative impact on HRQoL. Patients with active disease are more impaired than patients in remission. In our population of patients bowel and systemic dimensions had a predominant value in patients' perception of quality of life. Patients in our study using the same instrument scored higher than previously reported

Central nervous system relapse in patients with breast cancer is associated with advanced stages, with the presence of circulating occult tumor cells and with the HER2/neu status

INTRODUCTION: To evaluate the incidence of central nervous system (CNS) involvement in patients with breast cancer treated with a taxane-based chemotherapy regimen and to determine predictive factors for CNS relapse. METHODS: The medical files of patients with early breast cancer (n = 253) or advanced stage breast cancer (n = 239) as well of those with other solid tumors (n = 336) treated with or without a taxane-based chemotherapy regimen during a 42-month period were reviewed. HER2/neu overexpression was identified by immunohistochemistry, whereas cytokeratin 19 (CK-19) mRNA-positive circulating tumor cells (CTCs) in the peripheral blood were identified by real-time PCR. RESULTS: The incidence of CNS relapse was similar in patients suffering from breast cancer or other solid tumors (10.4% and 11.4%, respectively; P = 0.517). The incidence of CNS relapse was significantly higher in breast cancer patients with advanced disease (P = 0.041), visceral disease and bone disease (P = 0.036), in those who were treated with a taxane-containing regimen (P = 0.024), in those with HER2/neu-overexpressing tumors (P = 0.022) and, finally, in those with detectable CK-19 mRNA-positive CTCs (P = 0.008). Multivariate analysis revealed that the stage of disease (odds ratio, 0.23; 95% confidence interval, 0.007–0.23; P = 0.0001), the HER2/neu status (odds ratio, 29.4; 95% confidence interval, 7.51–101.21; P = 0.0001) and the presence of CK-19 mRNA-positive CTCs (odds ratio, 8.31; 95% confidence interval, 3.97–12.84; P = 0.001) were independent predictive factors for CNS relapse. CONCLUSION: CNS relapses are common among breast cancer patients treated with a taxane-based chemotherapy regimen, patients with HER2/neu-positive tumor and patients with CK-19 mRNA-positive CTCs

Maritime interest representation in the EU. European Political Economy Review Vol. 3, No. 2 (Winter 2005-2006), pp. 6-28

The EU constitutes a supranational policy-making jurisdiction that has moved decisively into the maritime transport policy field. A variety of maritime interests has identified a new level of power with the EU decision-making process and has re-targeted its lobbying strategies in order to influence the Common Maritime Transport Policy (CMTP). This article examines the patterns and the capabilities of this mobilisation. The first part focuses on the structures of these Euro-groups. Then, the analysis turns on the lobbying practices of these interests groups in the context of the EU co-decision process of policy-making. The final part weighs the extent that the ‘EU environment’ and the ‘economic environment’ assist, or undermine, the governability of these lobbying activities and their capacity to be coherent policy actors that serve the interests of their members in the long-term