218 research outputs found
Values and Identity in Jewish Education
This article identifies a set of values to guide the development of an ideal Jewish school; it then specifies a series of recommended organizational, curricular and instructional practices to address these values. The preface establishes the rationale for rethinking the substance and form of Jewish education in the United States
Viral MHCI inhibition evades tissue-resident memory T cell formation and responses
Tissue-resident memory CD
The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cells
The tissue-specific drivers of neurosarcoidosis remain poorly defined. To identify cerebrospinal fluid (CSF) specific, antigen-driven T and B cell responses, we performed single-cell RNA sequencing of CSF and blood cells from neurosarcoid participants coupled to T and B cell receptor sequencing. In contrast to pulmonary sarcoidosis, which is driven by CD4 T cells, we found CD8 T cell clonal expansion enriched in the neurosarcoid CSF. These CSF-enriched CD8 T cells were composed of two subsets with differential expression of EBI2, CXCR3, and CXCR4. Lastly, our data suggest that IFNγ signaling may distinguish neurosarcoidosis from other neurological disorders
An improved measurement of muon antineutrino disappearance in MINOS
We report an improved measurement of muon anti-neutrino disappearance over a
distance of 735km using the MINOS detectors and the Fermilab Main Injector
neutrino beam in a muon anti-neutrino enhanced configuration. From a total
exposure of 2.95e20 protons on target, of which 42% have not been previously
analyzed, we make the most precise measurement of the anti-neutrino
"atmospheric" delta-m squared = 2.62 +0.31/-0.28 (stat.) +/- 0.09 (syst.) and
constrain the anti-neutrino atmospheric mixing angle >0.75 (90%CL). These
values are in agreement with those measured for muon neutrinos, removing the
tension reported previously.Comment: 5 pages, 4 figures. In submission to Phys.Rev.Let
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Improved Search for Muon-Neutrino to Electron-Neutrino Oscillations in MINOS
We report the results of a search for ν_e appearance in a ν_μ beam in the MINOS long-baseline neutrino experiment. With an improved analysis and an increased exposure of 8.2×10^(20) protons on the NuMI target at Fermilab, we find 2sin^2(θ_(23))sin^2(2θ_(13))<0.12(0.20) at 90% confidence
level for δ=0 and the normal (inverted) neutrino mass hierarchy, with a best-fit of 2sin^2(θ_(23))sin^2(2θ_(13))=0.041^(+0.047)_(-0.031)(0.079^(+0.071)_(-0.053).
The θ_(13)= 0 hypothesis is disfavored by the MINOS data
at the 89% confidence level
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Search for the disappearance of muon antineutrinos in the NuMI neutrino beam
We report constraints on antineutrino oscillation parameters that were obtained by using the two MINOS detectors to measure the 7% muon antineutrino component of the NuMI neutrino beam. In the Far Detector, we select 130 events in the charged-current muon antineutrino sample, compared to a prediction of 136.4 ± 11.7(stat)^(+10.2)_(-8.9)(syst) events under the assumption │Δm^2│ = 2.32 X 10^(-3) eV^2, sin^2(2θ) = 1.0
Measurement of the neutrino mass splitting and flavor mixing by MINOS
Measurements of neutrino oscillations using the disappearance of muon neutrinos from the Fermilab NuMI neutrino beam as observed by the two MINOS detectors are reported. New analysis methods have been applied to an enlarged data sample from an exposure of protons on target. A fit to neutrino oscillations yields values of ,eV for the atmospheric mass splitting and m sin^2!(2 heta) > 0.90 (90%,C.L.) for the mixing angle. Pure neutrino decay and quantum decoherence hypotheses are excluded at 7 and 9 standard deviations, respectively
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Measurement of the Neutrino Mass Splitting and Flavor Mixing by MINOS
Measurements of neutrino oscillations using the disappearance of muon neutrinos from the Fermilab NuMI neutrino beam as observed by the two MINOS detectors are reported. New analysis methods have been applied to an enlarged data sample from an exposure of 7.25×10^(20) protons on target. A fit to neutrino oscillations yields values of |Δm^2|=(2.32_(-0.08)^(+0.12))×10^(-3)  eV^2 for the atmospheric mass splitting and sin^2(2θ)>0.90 (90% C.L.) for the mixing angle. Pure neutrino decay and quantum decoherence hypotheses are excluded at 7 and 9 standard deviations, respectively
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New constraints on muon-neutrino to electron-neutrino transitions in MINOS
This paper reports results from a search for ν_μ → ν_e transitions by the MINOS experiment based on a 7×10^(20) protons-on-target exposure. Our observation of 54 candidate ν_e events in the far detector with a background of 49.1±7.0(stat)±2.7(syst) events predicted by the measurements in the near detector requires 2sin^2(2θ_(13))sin^2θ_(23)<0.12(0.20) at the 90% C.L. for the normal (inverted) mass hierarchy at δ_(CP)=0. The experiment sets the tightest limits to date on the value of θ_(13) for nearly all values of δ_(CP) for the normal neutrino mass hierarchy and maximal sin^2(2θ_(23))
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Measurement of the underground atmospheric muon charge ratio using the MINOS Near Detector
The magnetized MINOS Near Detector, at a depth of 225 mwe, is used to measure the atmospheric muon charge ratio. The ratio of observed positive to negative atmospheric muon rates, using 301 days of data, is measured to be 1.266±0.001(stat)_(-0.014)^(+0.015)(syst). This measurement is consistent with previous results from other shallow underground detectors and is 0.108±0.019(stat+syst) lower than the measurement at the functionally identical MINOS Far Detector at a depth of 2070 mwe. This increase in charge ratio as a function of depth is consistent with an increase in the fraction of muons arising from kaon decay for increasing muon surface energie
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