Translational recoding as a feedback controller : systems approaches reveal polyamine-specific effects on the antizyme ribosomal frameshift

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A Prospective Open Labelled Non-Randomized Phase-II Clinical Trial on Pavattai Kudineer in the management of Thandaga Vatham

The disease THANDAGA VATHAM can be correlated with lumbar spondylosis is a degenerative changes in disc and lumbar spine. Disc degenerate is age related and starts in 4rd decade. Low back pain (LBP) affects approximately 60–85% in adult age. Fortunately, for the large majority of individuals, symptoms are mild and transient, with 90% subsiding within 6 weeks. Chronic low back pain, defined as pain symptoms persisting more than 3 months. Despite the high prevalence of low back pain within the general population, the diagnostic approach and therapeutic options are diverse and often inconsistent, resulting in rising costs and variability in management throughout the country. In part, this is due to the difficulty establishing a clear etiology for most patients, with known non receptive pain generators identified throughout the axial spine. Lumbar Spondylosis is defined as degenerative changes, without an associated disruption or defect in the vertebral disc. The clinical symptoms of degenerative spondylosis, or with neurogenic claudication and/or radicular pain, with or without axial back pain. In India Lumbar spondylosis affects 60-85% of the adults during some point in their lives. 84% of men and 74% of women are suffering from Lumbar spondylosis in the age group of 45-64 years of population is prone to develop disorders of vertebral column, like lumbar spondylosis, Prolapsed Intervertebral Disc (PID), osteoporosis and the degenerative disease of spine. Majority of them are suffering from PID or lumbar spondylosis. The principle line of treatment is to use of steroids, physiotherapy, NSAID. Which are having severe side effects on hepatioand renal systems. The treatment such as surgical intervention may inherit drawbacks like disability. Thandaga vatham is a characterized by severe pain in which the body is rendered like a log of wood, unable to stretch the limbs and pass urine and stools. In Thandaga vatham, according to Yugimuni and T.V. Sambasivampillai, can be clinically correlated in modern medicine is lumbar spondylosis. It is one among the 80 types of vatha diseases. This research will deal elaborately discussed about etiology, pathology, clinical features and complications of Thandaga vatham and Prognosis after using Siddha treatment the Pavattaiilai kudieer (Internal). So, in this situation I have been choosen Pavattai ilai kudieer for the management in Lumbar spondylosis. Conventional medicines and surgical treatments end up with side effects and leave with defect and detriment like recurrence of pain, disability & nerve root damage. This study is concerned with A Prospective open labelled non randomised Phase-II Clinical trial to assess the therapeutic efficacy of the siddha formulation PAVATTAI ILAI KUDINEER for the treatment of THANDAGA VATHAM (LUMBAR SPONDYLOSIS), described in Gunapadam Mooligai Vaguppu Part-I text book to detect whether any significant improvements and relief can be done. Totally 40 patients with Thandaga Vatham (30 In patients, 30 Out patients of both sex) were selected randomly from OPD of PothuMaruthuvam, Govt. Siddha Medical College, Tirunelveli, Tamil Nadu. They were given PavattaiIlai Kudineer 30ml twice a day for 45 days. After the course of treatment majority of cases showed good response which is statistically significant

The prion hypothesis: from biological anomaly to basic regulatory mechanism

Prions are unusual proteinaceous infectious agents that are typically associated with a class of fatal degenerative diseases of the mammalian brain. However, the discovery of fungal prions, which are not associated with disease, suggests that we must now consider the effect of these factors on basic cellular physiology in a different light. Fungal prions are epigenetic determinants that can alter a range of cellular processes, including metabolism and gene expression pathways, and these changes can lead to a range of prion-associated phenotypes. The mechanistic similarities between prion propagation in mammals and fungi suggest that prions are not a biological anomaly but instead could be a newly appreciated and perhaps ubiquitous regulatory mechanism