A tool for predicting heating uniformity in industrial radio frequency processing

Radio frequency energy is utilised for heating in a wide range of applications, particularly in the food industry. A major challenge of RF processing is non-uniform heating in loads of variable and angular geometry, leading to reduced quality and product damage. In the study, the specific effects of geometry on the heating profiles of a range of geometrically variable loads in an industrial scale RF system are analysed, and the understanding used to derive a general tool to predict heating uniformity. Potato was selected as a test material for experimental work; dielectric properties were measured using a 44mm coaxial probe. Analysis of simulated and experimental surface temperature profiles and simulated power uniformity indices indicates that the presence of vertices and edges on angular particles, and their proximity to faces perpendicular to the RF electrodes increases localised heating; faces parallel to the electrodes heated less than those faces perpendicular to them. Comparison of the same geometrical shape in different orientations indicates that overall power absorption uniformity can be better even when localised heating of edges is greater. It is suggested, for the first time, that the rotation of angular shapes within a parallel plate electric field can improve heating uniformity, and that this can be achieved through the design of bespoke electrode systems. A Euler characteristic based shape factor is proposed, again for the first time, that can predict heating uniformity for solid, dielectrically homogenous shapes. This provides industry with a tool to quickly determine the feasibility for uniform RF heating of different three dimensional shapes based on geometry alone. This provides a screening method for food technologists developing new products, allowing rapid assessment of potential heating uniformity and reducing the need for early stage specialist computational modelling

Biological basis of extensive pleiotropy between blood traits and cancer risk

Background: The immune system has a central role in preventing carcinogenesis. Alteration of systemic immune cell levels may increase cancer risk. However, the extent to which common genetic variation influences blood traits and cancer risk remains largely undetermined. Here, we identify pleiotropic variants and predict their underlying molecular and cellular alterations. Methods: Multivariate Cox regression was used to evaluate associations between blood traits and cancer diagnosis in cases in the UK Biobank. Shared genetic variants were identified from the summary statistics of the genome-wide association studies of 27 blood traits and 27 cancer types and subtypes, applying the conditional/conjunctional false-discovery rate approach. Analysis of genomic positions, expression quantitative trait loci, enhancers, regulatory marks, functionally defined gene sets, and bulk- and single-cell expression profiles predicted the biological impact of pleiotropic variants. Plasma small RNAs were sequenced to assess association with cancer diagnosis. Results: The study identified 4093 common genetic variants, involving 1248 gene loci, that contributed to blood-cancer pleiotropism. Genomic hotspots of pleiotropism include chromosomal regions 5p15-TERT and 6p21-HLA. Genes whose products are involved in regulating telomere length are found to be enriched in pleiotropic variants. Pleiotropic gene candidates are frequently linked to transcriptional programs that regulate hematopoiesis and define progenitor cell states of immune system development. Perturbation of the myeloid lineage is indicated by pleiotropic associations with defined master regulators and cell alterations. Eosinophil count is inversely associated with cancer risk. A high frequency of pleiotropic associations is also centered on the regulation of small noncoding Y-RNAs. Predicted pleiotropic Y-RNAs show specific regulatory marks and are overabundant in the normal tissue and blood of cancer patients. Analysis of plasma small RNAs in women who developed breast cancer indicates there is an overabundance of Y-RNA preceding neoplasm diagnosis. Conclusions: This study reveals extensive pleiotropism between blood traits and cancer risk. Pleiotropism is linked to factors and processes involved in hematopoietic development and immune system function, including components of the major histocompatibility complexes, and regulators of telomere length and myeloid lineage. Deregulation of Y-RNAs is also associated with pleiotropism. Overexpression of these elements might indicate increased cancer risk

Understanding the electromagnetic interaction of metal organic framework reactants in aqueous solution at microwave frequencies

Preparation of metal organic frameworks (MOFs) via microwave heating is becoming increasingly popular due to reduced reaction times and enhanced control of MOF particle size. However, there is little understanding about the detailed interaction of the electric field portion of the wave with reactants during the synthesis of MOFs. In order to overcome this lack of fundamental understanding, information about the dielectric properties of the reactants is required. In this work the dielectric constants (ε′) and loss factors (ε′′) of benzene-1,4-dicarboxylic acid (H2BDC; also known as terephthalic acid) and a number of M(III) (M = metal) salts dissolved in deionized water were measured as a function of frequency, temperature and concentration and with varying anions and cations. Dielectric data confirm the aqueous M(III) salts to be strong microwave absorbers, particularly at 915 MHz. M(III) salts with mono-anionic ligands (for example chlorides and nitrates) exhibit higher losses than di-anionic salts (sulfates) demonstrating that the former are heated more effectively in an applied microwave field. Of the M(III) salts containing either singly- or doubly-charged anions, those containing Fe(III) have the highest loss indicating that they will heat more efficiently than other M(III) salts such as Cr(III) and Al(III). Interestingly, H2BDC exhibits little interaction with the electric field at microwave frequencies

Ethics of automated vehicles: breaking traffic rules for road safety

In this paper, we explore and describe what is needed to allow connected and automated vehicles (CAVs) to break traffic rules in order to minimise road safety risk and to operate with appropriate transparency (according to recommendation 4 in Bonnefon et al., European Commission, 2020). Reviewing current traffic rules with particular reference to two driving situations (speeding and mounting the pavement), we illustrate why current traffic rules are not suitable for CAVs and why making new traffic rules specifically for CAVs would be inappropriate. In defining an alternative approach to achieving safe CAV driving behaviours, we describe the use of ethical goal functions as part of hybrid AI systems, suggesting that functions should be defined by governmental bodies with input from citizens and stakeholders. Ethical goal functions for CAVs would enable developers to optimise driving behaviours for safety under conditions of uncertainty whilst allowing for differentiation of products according to brand values. Such functions can differ between regions according to preferences for safety behaviours within that region and can be updated over time, responding to continual socio-technological feedback loops. We conclude that defining ethical goal functions is an urgent and necessary step from governmental bodies to enable the safe and transparent operation of CAVs and accelerate the reduction in road casualties they promise to achieve

An iterative procedure for solving FEM-BEM equations

A new very efficient iterative FEM-BEM hybrid procedure for solving stationary and steady state electromagnetic fields is proposed. The value of the magnetic vector potential is obtained from the integral equation on the boundary of the exterior domain for a given value of the normal derivative. Solving the interior problem using FEM with Dirichlet boundary conditions given by BEM proves to be very useful. Specific sparse matrix procedures may be used. It can be proven that a large enough value of the magnetic permeability assures the method convergence. Applying the fixed point polarization method to the nonlinear field problems allows the use of an arbitrary value of the magnetic permeability. Several illustrative examples are also presented

Ethics of Connected and Automated Vehicles: Recommendations on road safety, privacy, fairness, explainability and responsibility

Connected and Automated Vehicles (CAVs) are emerging as a new technology and new form of mobility in Europe. Expectations are high: these vehicles can bring down the number of road fatalities near zero; increase accessibility of mobility services; and help to reduce harmful emissions from transport by making traffic more efficient. However, technological progress alone will not be able to bring about the full potential of CAVs. The timely and systematic integration of ethical and societal considerations, from inception to use, will be essential to ensure their ethical and positive impact. With its strategy on Connected and Automated Mobility, the European Commission aims to make Europe a world leader in the development and deployment of CAVs. To tackle ethical issues, the Commission formed in 2019 an independent Expert Group to provide practical support to researchers, policymakers, manufacturers and developers in the safe and responsible transition towards connected and automated mobility. The 20 recommendations presented in this report consider ethical principles and shared moral values as stimuli in shaping CAV innovation, rather than be perceived as an obstruction to their progress

Understanding the Pattern of Oropharyngeal Cancers from North-East Romanian Patients

Background: Human papilloma virus (HPV) is acknowledged as a risk factor for oropharyngeal squamous cellular cancers (OPSCC), of which the dominant types are tonsillar (TSCC) and base of tongue cancer (BOTSCC). Objective: To assess the role of HPV in selected OPSCC cases, from Romanian patients by sensitive and complementary molecular assays. Material and Methods: Fifty-four formalin fixed paraffin embedded (FFPE) OPSCC samples were analyzed for HPV DNA by a PCR-based bead-based multiplex-assay. Thirty-four samples were tested for HPV RNA and for overexpression of p16INK4a by immunohistochemistry. Twenty samples were evaluated by Competitive Allele-Specific Taqman PCR (CAST-PCR) for fibroblast growth factor receptor 3 protein (FGFR3) status. Results: A total of 33.3% (18/54) OPSCC samples were positive for HPV DNA. HPV16 was the most frequent type (30%, 16/54); followed by HPV18 (3.7%, 2/54); and 1 sample (1.8%) was positive for both HPV16 and 18. HPV18 E6*I was detected in a HPV18 DNA-positive oropharynx tumor. Four samples positive for HPV16 were also positive for p16INK4a. All the tested samples were negative for FGFR3. Conclusions: The increased HPV16 prevalence is in line with similar studies and is a new confirmation that HPV16 is the most prevalent type in our country; supporting the potential benefit of prophylactic vaccines. Overall, there is no concordance between DNA and any of the two other analytes that are considered being markers of HPV-driven cancers. There is a need to explore novel screening strategies that could be broadly used in the clinical routine to initiate preventive measures