The evolution of cataclysmic variables

Cataclysmic variables (CVs) are short–period (' 80 min to ' day) binaries in which a white dwarf accretes from a low–mass companion. Since both stellar components are structurally simple and there is a sufficiently large number of relatively bright CVs known, it is possible to carry out detailed observational population studies. Therefore CVs are one of the best–suited classes to test, constrain, and further develop our understanding of the evolution of all interacting compact binaries, such as black hole binaries, X-ray transients, milli–second pulsars and, more importantly, Type Ia Supernova (SN Ia), our yardsticks for measuring distances on cosmological distance scales. In this thesis, I present the study of a large sample of CV white dwarfs. Their effective temperatures are determined from the analysis of their ultraviolet Hubble Space Telescope (HST ) spectra and provide a test for the current models of CV evolution. Our results highlight the presence of a number of discrepancies between current population models and observations, particularly the lack of period bounce systems, i.e. highly evolved CVs with brown dwarf companions, which are predicted to make up for ' 40 . 70 % of the present day Galactic CV population. The combination of the HST data with optical phase–resolved X–shooter observations is a powerful tool to identify period bouncers. We study the spectral energy distribution of QZ Lib, in which we identify the coolest white dwarf at the longest orbital period below the period gap and we spectroscopically confirm the presence of a brown dwarf donor. These characteristics make QZ Lib the strongest period bouncer candidate identified so far. Although successful, this method requires the use of expensive space–based and large ground–based facilities, indicating the need for a more efficient observing strategy. We present here CHiCaS, the Compact binary HIgh CAdence Survey which represents the first systematic attempt to identify, via the detection of their eclipses, the elusive population of period bouncers. By the end of next year, this program will deliver one minute cadence lightcurves for ' 2:5 million objects as faint as g ' 21:5, along with full colour information. CHiCaS will also provide a complete and unbiased view into the short term variability of thousands of binaries, eclipsing systems, pulsating stars and CVs in the period gap. In our HST sample, we identify another remarkable CV: SDSS J123813.73–033932.9. Its lightcurve shows sudden increases in brightness, up to ' 0:45 mag, occurring quasi–periodically every 8–12 hours (the “brightenings”) and a nearly sinusoidal variation at half the orbital period (the “double–humps”). The HST observations show that these phenomena arise from the heating and cooling of a fraction of the white dwarf, which we conclude being caused by a modulation in the accretion rate owing to spiral density waves and thermal instabilities in the accretion disc

Evidence for reduced magnetic braking in polars from binary population models

We present the first population synthesis of synchronous magnetic cataclysmic variables, called polars, taking into account the effect of the white dwarf (WD) magnetic field on angular momentum loss. We implemented the reduced magnetic braking (MB) model proposed by Li, Wu & Wickramasinghe into the Binary Stellar Evolution (BSE) code recently calibrated for cataclysmic variable (CV) evolution. We then compared separately our predictions for polars and non-magnetic CVs with a large and homogeneous sample of observed CVs from the Sloan Digital Sky Survey. We found that the predicted orbital period distributions and space densities agree with the observations if period bouncers are excluded. For polars, we also find agreement between predicted and observed mass transfer rates, while the mass transfer rates of non-magnetic CVs with periods ≳3 h drastically disagree with those derived from observations. Our results provide strong evidence that the reduced MB model for the evolution of highly magnetized accreting WDs can explain the observed properties of polars. The remaining main issues in our understanding of CV evolution are the origin of the large number of highly magnetic WDs, the large scatter of the observed mass transfer rates for non-magnetic systems with periods ≳3 h, and the absence of period bouncers in observed samples

The cataclysmic variable QZ Lib : a period bouncer

While highly evolved cataclysmic variables (CVs) with brown dwarf donors, often called “period bouncers”, are predicted to make up ≃ 40 − 70% of the Galactic CV population, only a handful of such systems are currently known. The identification and characterization of additional period bouncers is therefore important to probe this poorly understood phase of CV evolution. We investigate the evolution of the CV QZ Lib following its 2004 super–outburst using multi–epoch spectroscopy. From time– resolved spectroscopic observations we measure the orbital period of the system, Porb = 0.06436(20) d, which, combined with the superhump period PSH = 0.064602(24) d, yields the system mass ratio, q = 0.040(9). From the analysis of the spectral energy distribution we determine the structure of the accretion disc and the white dwarf effective temperature, Teff = 10 500 ± 1500 K. We also derive an upper limit on the effective temperature of the secondary, Teff < 1700 K, corresponding to a brown dwarf of T spectral type. The low temperature of the white dwarf, the small mass ratio and the fact that the donor is not dominating the near–infrared emission are all clues of a post bounce system. Although it is possible that QZ Lib could have formed as a white dwarf plus a brown dwarf binary, binary population synthesis studies clearly suggest this scenario to be less likely than a period bouncer detection and we conclude that QZ Lib is a CV that has already evolved through the period minimum

Hubble Space Telescope ultraviolet light curves reveal interesting properties of CC Sculptoris and RZ Leonis

Time-tag ultraviolet data obtained on the Hubble Space Telescope in 2013 reveal interesting variability related to the white dwarf spin in the two cataclysmic variables RZ Leo and CC Scl. RZ Leo shows a period at 220 s and its harmonic at 110 s, thus identifying it as a likely Intermediate Polar (IP). The spin signal is not visible in a short single night of ground-based data in 2016, but the shorter exposures in that data set indicate a possible partial eclipse. The much larger UV amplitude of the spin signal in the known IP CC Scl allows the spin of 389 s, previously only seen at outburst, to be visible at quiescence. Spectra created from the peaks and troughs of the spin times indicate a hotter temperature of several thousand degrees during the peak phases, with multiple components contributing to the UV light

The age–metallicity relation in the solar neighbourhood from a pilot sample of white dwarf–main sequence binaries

The age–metallicity relation (AMR) is a fundamental observational constraint for understanding how the Galactic disc formed and evolved chemically in time. However, there is not yet an agreement on the observational properties of the AMR for the solar neighbourhood, primarily due to the difficulty in obtaining accurate stellar ages for individual field stars. We have started an observational campaign for providing the much needed observational input by using wide white-dwarf–main-sequence (WDMS) binaries. White dwarfs are ‘natural’ clocks and can be used to derive accurate ages. Metallicities can be obtained from the main-sequence companions. Since the progenitors of white dwarfs and the main-sequence stars were born at the same time, WDMS binaries provide a unique opportunity to observationally constrain in a robust way the properties of the AMR. In this work we present the AMR derived from analysing a pilot sample of 23 WDMS binaries and provide clear observational evidence for the lack of correlation between age and metallicity at young and intermediate age

B-cell reconstitution after lentiviral vector-mediated gene therapy in patients with Wiskott-Aldrich syndrome

Background Wiskott-Aldrich syndrome (WAS) is a severe X-linked immunodeficiency characterized by microthrombocytopenia, eczema, recurrent infections, and susceptibility to autoimmunity and lymphomas. Hematopoietic stem cell transplantation is the treatment of choice; however, administration of WAS gene-corrected autologous hematopoietic stem cells has been demonstrated as a feasible alternative therapeutic approach. Objective Because B-cell homeostasis is perturbed in patients with WAS and restoration of immune competence is one of the main therapeutic goals, we have evaluated reconstitution of the B-cell compartment in 4 patients who received autologous hematopoietic stem cells transduced with lentiviral vector after a reduced-intensity conditioning regimen combined with anti-CD20 administration. Methods We evaluated B-cell counts, B-cell subset distribution, B cell-activating factor and immunoglobulin levels, and autoantibody production before and after gene therapy (GT). WAS gene transfer in B cells was assessed by measuring vector copy numbers and expression of Wiskott-Aldrich syndrome protein. Results After lentiviral vector-mediated GT, the number of transduced B cells progressively increased in the peripheral blood of all patients. Lentiviral vector-transduced progenitor cells were able to repopulate the B-cell compartment with a normal distribution of B-cell subsets both in bone marrow and the periphery, showing a WAS protein expression profile similar to that of healthy donors. In addition, after GT, we observed a normalized frequency of autoimmune-associated CD19+CD21-CD35- and CD21low

Ancient Migratory Events in the Middle East: New Clues from the Y-Chromosome Variation of Modern Iranians

Knowledge of high resolution Y-chromosome haplogroup diversification within Iran provides important geographic context regarding the spread and compartmentalization of male lineages in the Middle East and southwestern Asia. At present, the Iranian population is characterized by an extraordinary mix of different ethnic groups speaking a variety of Indo-Iranian, Semitic and Turkic languages. Despite these features, only few studies have investigated the multiethnic components of the Iranian gene pool. In this survey 938 Iranian male DNAs belonging to 15 ethnic groups from 14 Iranian provinces were analyzed for 84 Y-chromosome biallelic markers and 10 STRs. The results show an autochthonous but non-homogeneous ancient background mainly composed by J2a sub-clades with different external contributions. The phylogeography of the main haplogroups allowed identifying post-glacial and Neolithic expansions toward western Eurasia but also recent movements towards the Iranian region from western Eurasia (R1b-L23), Central Asia (Q-M25), Asia Minor (J2a-M92) and southern Mesopotamia (J1-Page08). In spite of the presence of important geographic barriers (Zagros and Alborz mountain ranges, and the Dasht-e Kavir and Dash-e Lut deserts) which may have limited gene flow, AMOVA analysis revealed that language, in addition to geography, has played an important role in shaping the nowadays Iranian gene pool. Overall, this study provides a portrait of the Y-chromosomal variation in Iran, useful for depicting a more comprehensive history of the peoples of this area as well as for reconstructing ancient migration routes. In addition, our results evidence the important role of the Iranian plateau as source and recipient of gene flow between culturally and genetically distinct population

Predicting circulating CA125 levels among healthy premenopausal women

Background: Cancer antigen 125 (CA125) is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women. Methods: We evaluated predictors of CA125 levels among 815 premenopausal women from the New England Case Control Study (NEC). We developed linear and dichotomous (≥35 U/mL) CA125 prediction models and externally validated an abridged model restricting to available predictors among 473 premenopausal women in the European Prospective Investigation into Cancer and Nutrition Study (EPIC). Results: The final linear CA125 prediction model included age, race, tubal ligation, endometriosis, menstrual phase at blood draw, and fibroids, which explained 7% of the total variance of CA125. The correlation between observed and predicted CA125 levels based on the abridged model (including age, race, and menstrual phase at blood draw) had similar correlation coefficients in NEC (r = 0.22) and in EPIC (r = 0.22). The dichotomous CA125 prediction model included age, tubal ligation, endometriosis, prior personal cancer diagnosis, family history of ovarian cancer, number of miscarriages, menstrual phase at blood draw, and smoking status with AUC of 0.83. The abridged dichotomous model (including age, number of miscarriages, menstrual phase at blood draw, and smoking status) showed similar AUCs in NEC (0.73) and in EPIC (0.78). Conclusions: We identified a combination of factors associated with CA125 levels in premenopausal women. Impact: Our model could be valuable in identifying healthy women likely to have elevated CA125 and consequently improve its specificity for ovarian cancer screening