Upaya Peningkatan Kesejahteran Keluarga Melalui Pemberdayaan pada Kelompok Perempuan Sido Makmur di Desa Pasrujambe

Abstract This research was aimed at describing and analyzing the efforts devoted to escalating family prosperity through empowerment on Sido Makmur of woman community in Pasrujambe village. Research question under investigation was germane to how the efforts devoted to improving family prosperity on Sido Makmur woman community were carried out to improve the prosperity of families in Pasrujambe village. The presence of empowerment carried out in Sido Makmur community was one a kind of farming-based woman community which was intended to rally the appreciations of farming women. The research method operative in the study was descriptive, which was coupled with qualitative approach. The research site was Pasrujambe village, Pasrujambe sub-district of Lumajang district. Research informants were determined by purposive sampling, leading to including primary and secondary informants. To gain research data, observation, interview, and documentation were operationalized. Upon testing data validity, the researcher applied source trianglation. Research findings revealed that the empowerment to household women was done by enacting Sido Makmur woman community, through which various soft skill and  hard skills trainings were given. As a corollary, such undertakings exerted benefits to family prosperity in the form of economy improvement, knowledge improvement, and improvement.&nbsp

Praktik Pekerja Sosial dalam Perlindungan Pekerja Anak di Pertanian Tembakau melalui Program We Protect

Pekerja anak termasuk ke dalam kategori anak rawan, khususnya yang bekerja di pertanian tembakau. Sebagai upaya perlindungan, Yayasan Social Transformation and Public Awareness (STAPA) Center memiliki program perlindungan terhadap pekerja anak di pertanian tembakau melalui program We Protect. Salah satu tim dalam menjalankan program tersebut adalah profesi pekerja sosial. Profesi pekerja sosial dalam melakukan intervensi terhadap pekerja anak menggunakan metode intervensi pekerja sosial makro. Tujuan penelitian untuk mendeskripsikan proses praktik pekerja sosial dalam program We Protect dengan menggunakan pendekatan deskriptif kualitatif. Penggalian data dengan wawancara, observasi dan studi dokumentasi. Analisis data dilakukan dengan teknik analisis intergratif mulai dari pengumpulan data, reduksi data, penyajian data, serta kesimpulan. Hasil penelitian yakni praktik pekerjaan sosial dalam perlindungan pekerja anak di pertanian tembakau melalui program We Protect dilakukan melalui kegiatan pemberian pendidikan keterampilan hidup kepada pekerja anak. Tahapan praktik pekerjaan sosial dilakukan melalui proses engangement, intake and contract, assessment, planning, intervention, evaluation dan and termination. Praktik di tahap engagement dan intake, pekerja sosial melakukan diseminasi program. Kemudian melakukan contract sebagai persetujuan pelaksanaan program. Pada assessment, pekerja sosial melakukan pemetaan yang dibantu dengan calon relawan lokal. Pada tahap planning, dilakukan rekrutmen dan pelatihan relawan lokal serta menyusun modul pembelajaran. Pada tahap intervention dilakukan pembelajaran keterampilan hidup melalui Rumah Kreasi yang memberikan layanan kelompok belajar, pojok literasi, taman edukasi, kelas remaja kreatif dan pelatihan vocational. Sedangkan pada evaluation dilakukan rutin minimal 1 bulan sekali. Tahap termination belum dilakukan karena masih dalam proses pelaksanaan program

The familial dementia gene revisited: a missense mutation revealed by whole exome sequencing identifies ITM2B as a candidate gene underlying a novel autosomal dominant retinal dystrophy in a large family

Audo, Isabelle et al.Inherited retinal diseases are a group of clinically and genetically heterogeneous disorders for which a significant number of cases remain genetically unresolved. Increasing knowledge on underlying pathogenic mechanisms with precise phenotype-genotype correlation is, however, critical for establishing novel therapeutic interventions for these yet incurable neurodegenerative conditions. We report phenotypic and genetic characterization of a large family presenting an unusual autosomal dominant retinal dystrophy. Phenotypic characterization revealed a retinopathy dominated by inner retinal dysfunction and ganglion cell abnormalities. Whole-exome sequencing identified a missense variant (c.782A>C, p.Glu261Ala) in ITM2B coding for Integral Membrane Protein 2B, which co-segregates with the disease in this large family and lies within the 24.6 Mb interval identified by microsatellite haplotyping. The physiological role of ITM2B remains unclear and has never been investigated in the retina. RNA in situ hybridization reveals Itm2b mRNA in inner nuclear and ganglion cell layers within the retina, with immunostaining demonstrating the presence of the corresponding protein in the same layers. Furthermore, ITM2B in the retina co-localizes with its known interacting partner in cerebral tissue, the amyloid ß precursor protein, critical in Alzheimer disease physiopathology. Interestingly, two distinct ITM2B mutations, both resulting in a longer protein product, had already been reported in two large autosomal dominant families with Alzheimer-like dementia but never in subjects with isolated retinal diseases. These findings should better define pathogenic mechanism(s) associated with ITM2B mutations underlying dementia or retinal disease and add a new candidate to the list of genes involved in inherited retinal dystrophies.The project was supported by GIS-maladies rares (C.Z.), Retina France (part of the 100-Exome Project) (I.A., J.-A.S. and C.Z.), Foundation Voir et Entendre (C.Z.), Foundation Fighting Blindness (FFB) grant CD-CL-0808-0466-CHNO (I.A. and the CIC503, recognized as an FFB centre), FFB grant C-CMM-0907-0428-INSERM04, Ville de Paris and Region Ile de France and by the French State programme ‘Investissements d’Avenir’ managed by the Agence Nationale de la Recherche (LIFESENSES: ANR-10-LABX-65)Peer Reviewe