COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)

Background: Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. Methods: The survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020. Results: The study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients (n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March–May 2020) and the second wave (October–December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. Conclusions: This survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases.EPICOVIDEHA has received funds from Optics COMMITTM (COVID-19 Unmet Medical Needs and Associated Research Extension) COVID-19 RFP program by GILEAD Science, United States (Project 2020-8223)

Values, concern, beliefs, and preference for solar energy: A comparative analysis of three European countries

Environmental research has increasingly recognised the relevance of energy-efficiency behaviours to mitigate climate change. In this perspective, we exploit data from the European Social Survey round 8 (2016) to provide new insights into the main factors leading to the preference for solar power in three European countries – France, Germany, and the United Kingdom. A Structural Equation Model is adopted to assess the impact of self- transcendent values, efficacy beliefs and concern about energy security on such preference. Our outcomes suggest the key role of self-transcendent values in driving preference for solar energy in all the analysed countries. On the other hand, the impact of efficacy beliefs and concern on such preference shows interesting cross-country differences: beliefs are relevant in France and Germany, while concern provides more guidance for French and British citizens. The provided evidence may assist policymakers in increasing the adoption of green energy sources among citizens, sustainably enhancing economic growth

Assessing the role of perceived values and felt responsibility on proenvironmental behaviours: A comparison across four EU countries

The study aims at providing a better understanding of the main factors leading to environmentally-friendly practices by investigating the relationships among perceived values, felt responsibility, and pro-environmental behaviours. The analysis is performed with reference to four developed European countries – France, Germany, Italy, and the United Kingdom. Based on Eurobarometer data (2017) on the attitudes of Europeans towards the environment, a structural equation modelling approach reveals positive and significant relationships among the three constructs, with interesting cross-country differences. In Italy and the United Kingdom, perceived values are directly associated with pro-environmental behaviour, while in Germany and France, where the cultural European identity appears to be more salient, values provide less guidance for behaviour. These findings may assist policymakers in developing a set of well-designed strategies for strengthening citizens’ pro-environmental habits through the reinforcement of values and feeling of responsibility