Synthesis and Bioassay of Azolyl Benzothiazine Carboxamides

Cyclic sulfonamides (sultams) gained importance due to their potential pharmaceutical activity. Amongst these, 1,2-benzothiazine-1,1-dioxide and their derivatives represent the most familiar class of non-steroidal anti-inflammatory drugs (NSAIDs) available in the market. In fact, Meloxicam and Piroxicam, the members of oxicam family are used as an analgesic and anti-inflammatory drugs. Azoles are potential chemical entities with a wide range of pharmacological activities such as anticancer, antibacterial, antifungal, antiviral and antiparasitic. In continuation of our efforts to develop potential multifunctional heterocycles, we have synthesized novel azolylbenzothiazine carboxamides and studied their cytotoxic and antioxidant activities. The results of these aspects will be discussed. © 2020 Author(s).The authors Venkatapuram Padmavathi and Panga Siva Sankar are grateful to CSIR (Council of Scientific and Industrial Research), New Delhi for financial assistance under the major research project

Synthesis of Carboxamide and Sulfonyl Carboxamide Linked Azoles Under Green Conditions

Direct coupling of heteroaldehydes with heteroaryl amines/sulfonylamines is performed under green conditions using PEG-400 in the presence of oxidant CCl3CN/H2O2. The presence of electron-withdrawing substituents on heteroaldehydes increased the yield. Further heteroaryl amines favor the reaction when compared with heteroaryl sulfonylamines. © 2020 Author(s).One of the authors G. Lakshmi Teja is indebted to the University Grants Commission (UGC), New Delhi for sanction of UGC-BSR fellowship

PRIVACY PRESERVING POLICY UPDATE FOR BIG DATA ACCESS CONTROL IN THE CLOUD COMPUTING

Big data majorly associated with  the high volume and velocity , it is an effective option to store big data in the cloud, as the cloud has capabilities of storing big data and processing high volume of user access requests. Attribute-Based Encryption (ABE) is a promising technique to ensure the end-to-end security of big data in the cloud. However, the policy updating has always been a challenging issue when ABE is used to construct access control schemes. A trivial implementation is to let data owners retrieve the data and re-encrypt it under the new access policy, and then send it back to the cloud. This method, however, incurs a high communication overhead and heavy computation burden on data owners. A novel scheme is proposed that enable efficient access control with dynamic policy updating for big data in the cloud. Developing an outsourced policy updating method for ABE systems is focused. This method can avoid the transmission of encrypted data and minimize the computation work of data owners, by making use of the previously encrypted data with old access policies. Policy updating algorithms is proposed for different types of access policies. An efficient and secure method is proposed that allows data owner to check whether the cloud server has updated the ciphertexts correctly. The analysis shows that this policy updating outsourcing scheme is correct, complete, secure and efficient

Synthesis of Heteroaryl Urea Derivatives as Antimicrobial Agents

Azoles are prominent scaffolds in the pharmaceutical arena. In fact, medicinal properties of azole and benzazole containing compounds include anticancer, antimicrobial and antioxidant. Some of the drugs Inthomycin C, Oxaprozin, Tiazofurin, Dacarbazine, Tipifarnib, Albendazole, Febendazole, Omeprazole possess azole/benzazole moiety. Realizing the importance of azoles and benzazoles, it is planned to conjugate these two ligands as heteroaryl substituted urea derivatives and to study their antimicrobial activity. The results pertaining to these aspects will be discussed. © 2020 Author(s).The authors K. Narendra Babu and V. Padmavathi are grateful to CSIR (Council of Scientific and Industrial Research), New Delhi for financial assistance under major research project

Antidiabetic activity of Manomani chooranam aqueous extract on female wistar albino rats

Background: The aim of the present study was to evaluate the antidiabetic potential of Manomani chooranam (MMC), an indigenous polyherbal siddha formulation in Streptozotocin (STZ) induced diabetic female Wistar albino rats.Methods: Aqueous extract of MMC was prepared. Wistar albino rats were divided into six groups (n=6). Group 1 was kept as normal control, Group 2, 3, 4, 5 and 6 were induced diabetes. After induction, the group 2 was kept as diabetes control; Group 3 received the standard drug metformin (100 mg/kg), whereas Groups 4, 5 and 6 were treated with the aqueous extract of MMC at 500 mg/kg, 1000 mg/kg and 1250 mg/kg doses, respectively for the 21 days. Blood sugar was estimated at the end of each week. At the end of the study, rats were sacrificed and the pancreas was analyzed for histopathological changes. Data expressed as mean±standard error of the mean. Statistical analysis was done using one-way ANOVA followed by post hoc Tukey's test. p<0.05 considered statistically significant.Results: The groups which received aqueous extract of MMC at 500 mg/kg, 1000 mg/kg and 1250 mg/kg showed a significant decrease in the mean blood sugar level when compared to normal level. The groups which received MMC shows significant reduction in blood sugar level in comparison with standard drug metformin 100 mg/kg.Conclusions: The aqueous extract of MMC was able to decrease the elevated blood sugar levels in dose dependent manner

Preparation of some 5,7-diarylcyclohexeno[3,4-d]-l-selena-2,3-diazolyl-6- spiro-5'-(2',3'-pyrazolidine / 2',3'-oxazolidine)-l ',4'-diones and 5,7-diarylcyclohexeno[3,4-d]-1-thia-2,3-diazolyl-6-spiro-5'(2',3'-pyrazolidine/2',3'-oxazolidine )-1',4'-diones

167-17

2,6-Diaryl pyridinium cation-A precursor in the cleavage process of 5,7-diarylpiperidino[ [3,4-d]-l,2,3-selenadiazolesl thiadiazoles

1194-119

Synthesis and bioassay of azolyl benzothiazine carboxamides

Cyclic sulfonamides (sultams) gained importance due to their potential pharmaceutical activity. Amongst these, 1,2-benzothiazine-1,1-dioxide and their derivatives represent the most familiar class of non-steroidal anti-inflammatory drugs (NSAIDs) available in the market. In fact, Meloxicam and Piroxicam, the members of oxicam family are used as an analgesic and anti-inflammatory drugs. Azoles are potential chemical entities with a wide range of pharmacological activities such as anticancer, antibacterial, antifungal, antiviral and antiparasitic. In continuation of our efforts to develop potential multifunctional heterocycles, we have synthesized novel azolylbenzothiazine carboxamides and studied their cytotoxic and antioxidant activities. The results of these aspects will be discussed. © 2020 Author(s).The authors Venkatapuram Padmavathi and Panga Siva Sankar are grateful to CSIR (Council of Scientific and Industrial Research), New Delhi for financial assistance under the major research project

Magnolol: A neolignan from the Magnolia family for the prevention and treatment of cancer

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will increase in future and will create global havoc, designating it as an epidemic. Conventional chemotherapeutics and treatment with synthetic disciplines are often associated with adverse side effects and development of chemoresistance. Thus, discovering novel economic and patient friendly drugs that are safe and efficacious is warranted. Several natural compounds have proved their potential against this dreadful disease so far. Magnolol is a hydroxylated biphenyl isolated from the root and stem bark of Magnolia tree. Magnolol can efficiently prevent or inhibit the growth of various cancers originating from different organs such as brain, breast, cervical, colon, liver, lung, prostate, skin, etc. Considering these perspectives, the current review primarily focuses on the fascinating role of magnolol against various types of cancers, and the source and chemistry of magnolol and the molecular mechanism underlying the targets of magnolol are discussed. This review proposes magnolol as a suitable candidate that can be appropriately designed and established into a potent anti-cancer drug