The Eco Office: Dynamic and Homeostatic Facades inspired by BIOMORPHIM, BIOMIMICRY, and BIOPHILIA

"Come forth into the light of things, Let Nature be your teacher.” ~ William Wordsworth The focus of this dissertation research is to extend and increase an understanding of sustainable building envelope design strategies, with specific focus on transfer of light, air, and heat, within a tropical site setting/context. Biomimetic architecture is a process that is primarily driven by inspiration from natural systems and organisms. Designs and patterns found in nature are often resolved at the “macro” as well as at the “micro/nano” molecular levels, which prompts further investigation into present-day advancements in material science and nanotechnological concepts. Nanotechnology is a way of looking closer at systems and material structures and properties; the translation from biomimetic architecture to the nano-molecular scale of materials thus promotes sustainability in buildings, by providing ways and means to incorporate new technologies and novel material systems into the architectural design of building facades, that will further aid with the successful implementation of passive design strategies, in order to establish comfortable interior lighting, ventilation, and thermal conditions. Extensive literature reviews and material research are utilized for the bio-tonano design process and analyses. Performance of design modules created has been tested using design simulations and reiterative analysis processes. “Taking cues from Nature – creation of responsive (environment and human responsive) architecture” – is the idea that is the primary motivation behind the research focus. The key goal of this research is to propose alternative futures in building envelope design, for a site in Honolulu, which would serve as a digital prototype for similar such investigations into integrating nature-inspired macro and nanotechnology structures and materials into building systems design. Psychophysiology (the mind-body-interaction) and experimental testing is used as part of the final testing and analysis, to assess people’s responses to nature-inspired design and emerging building technologies

BIOLOGICAL BASIS OF VARIABILITY IN DOPAMINE AVAILABILITY ON FRONTOSTRIATAL BRAIN FUNCTION IN ADOLESCENCE

Neurodevelopmental studies indicate a protracted development through adolescence of brain systems underlying incentive-driven behaviors including prefrontal cortex (PFC) and the striatum. These systems support the executive control of behavior as well as motivationally driven behaviors and may contribute to vulnerabilities in the emergence of psychopathology. The PFC and striatum may support cognition and motivation through the function of the neurotransmitter dopamine. Dopamine (DA) availability is increased during the adolescent period in human and animals and play an important role in mediating individual differences in risk-taking behaviors. This dissertation seeks to examine the moderating role of genetically mediated DA availability on frontostriatal brain function in adolescence. To this end, we genotyped individuals between the ages of 10 and 20 for common functional polymorphisms in three genes that have a direct influence on synaptic DA availability. In addition, we calculated a multilocus composite score in order to assess additive effects of our three genetic loci. We used functional magnetic resonance imaging (fMRI) to assess brain function. The purpose of our first study was to examine the integrity of frontostriatal networks using resting state functional connectivity. We then look more directly at the role of frontostriatal brain function on incentive-driven behaviors using a rewarded inhibitory control task that has a known developmental signature . Overall we found a moderating influence of DA availability on age-related changes in key frontostriatal circuitry suggesting that the maturation of brain function in adolescence may in part be mediated by inter-individual variability in DA signaling. Overall, the genotypes by age interactions highlight a unique DA-driven brain profile in adolescence. This suggests that a genetically mediated brain phenotype characterized in adolescence may differ significantly from that in adulthood. This has strong implications regarding the variability observed in adolescent risk-taking behaviors as well as predictions of later adult behavior

Developmental Changes in Brain Function Underlying the Influence of Reward Processing on Inhibitory Control

Adolescence is a period marked by changes in motivational and cognitive brain systems. However, the development of the interactions between reward and cognitive control processing are just beginning to be understood. Using event-related functional neuroimaging and an incentive modulated antisaccade task, we compared blood-oxygen level dependent activity underlying motivated response inhibition in children, adolescents, and adults. Behaviorally, children and adolescents performed significantly worse than adults during neutral trials. However, children and adolescents showed significant performance increases during reward trials. Adults showed no performance changes across conditions. fMRI results demonstrated that all groups recruited a similar circuitry to support task performance, including regions typically associated with rewards (striatum and orbital frontal cortex), and regions known to be involved in inhibitory control (putative frontal and supplementary eye fields, and posterior parietal cortex, and prefrontal loci). During rewarded trials adolescents showed increased activity in striatal regions, while adults demonstrated heightened activation in the OFC relative to children and adolescents. Children showed greater reliance on prefrontal executive regions that may be related to increased effort inhibiting responses. Overall, these results indicate that response inhibition is enhanced with reward contingencies over development. Adolescents' heightened response in striatal regions may be one factor contributing to reward-biased decision making and perhaps risk taking behavior

A CBT-based mobile intervention as an adjunct treatment for adolescents with symptoms of depression: a virtual randomized controlled feasibility trial

BackgroundHigh rates of adolescent depression demand for more effective, accessible treatment options. A virtual randomized controlled trial was used to assess the feasibility and acceptability of a 5-week, self-guided, cognitive behavioral therapy (CBT)-based mobile application, Spark, compared to a psychoeducational mobile application (Active Control) as an adjunct treatment for adolescents with depression during the COVID-19 pandemic.MethodsA community sample aged 13–21, with self-reported symptoms of depression, was recruited nationwide. Participants were randomly assigned to use either Spark or Active Control (NSpark = 35; NActive Control = 25). Questionnaires, including the PHQ-8 measuring depression symptoms, completed before, during, and immediately following completion of the intervention, evaluated depressive symptoms, usability, engagement, and participant safety. App engagement data were also analyzed.Results60 eligible adolescents (female = 47) were enrolled in 2 months. 35.6% of those expressing interest were consented and all enrolled. Study retention was high (85%). Spark users rated the app as usable (System Usability Scalemean = 80.67) and engaging (User Engagement Scale-Short Formmean = 3.62). Median daily use was 29%, and 23% completed all levels. There was a significant negative relationship between behavioral activations completed and change in PHQ-8. Efficacy analyses revealed a significant main effect of time, F = 40.60, p < .001, associated with decreased PHQ-8 scores over time. There was no significant Group × Time interaction (F = 0.13, p = .72) though the numeric decrease in PHQ-8 was greater for Spark (4.69 vs. 3.56). No serious adverse events or adverse device effects were reported for Spark users. Two serious adverse events reported in the Active Control group were addressed per our safety protocol.ConclusionRecruitment, enrollment, and retention rates demonstrated study feasibility by being comparable or better than other mental health apps. Spark was highly acceptable relative to published norms. The study's novel safety protocol efficiently detected and managed adverse events. The lack of significant difference in depression symptom reduction between Spark and Active Control may be explained by study design and study design factors. Procedures established during this feasibility study will be leveraged for subsequent powered clinical trials evaluating app efficacy and safety.Clinical Trial Registrationhttps://clinicaltrials.gov/ct2/show/NCT0452459

Tanglish

Language documentation and description of Tanglish

Stormwater evaluation and site assessment - a multidisciplinary approach for stormwater Best Management Practices (BMPs)

Master of Landscape ArchitectureDepartment of Landscape Architecture/Regional and Community PlanningLee R. SkabelundStormwater management is typically approached from different perspectives by practicing professionals. As such, stormwater planning/design is not always completed as a multi-disciplinary coalition of experts using holistic and synergistic methods. For a number of years, engineers and design professionals, particularly landscape architects, have been employing various strategies and techniques to address on-site stormwater management in terms of water quality and quantity. There is increasing awareness that in order to create solutions that are effective over both the short and long-term a landscape architect’s approach needs to account for the health, safety and welfare perspectives carried by engineers, the unique aspects of particular project sites, their surroundings and bio-regional context, as well as the perceptions of clients, other key stakeholders, and the broader public. This research investigates the various criteria integral to developing an analytic framework for ecologically-appropriate stormwater planning/design (Sustainable Stormwater Evaluation and Site Assessment or SSWESA). SSWESA is proposed as a type of decision-tree for site analysis of sustainable systems pertaining to stormwater. Using the SSWESA process is expected to help researchers and professionals make better planning and design decisions as they select and implement appropriate best management practices (BMPs) for a given site and context. My intent in developing SSWESA is to help designers assess existing and potential stormwater functions at the site scale in order to promote sustainable planning and design based upon the important principle: “First, do no harm”. It is also my intent to promote further research related to sustainability by providing references and sources from experts in the various fields related to ecologically-based stormwater management. A review of the literature related to ecological factors relevant to low impact stormwater management assisted in the development and refinement of the criteria for stormwater assessment and evaluation. In this report, the SSWESA framework is tested on a public school property in Manhattan, Kansas to demonstrate how the framework is applied and to understand the questions and issues that arise from its use

A Neurodevelopmental Shift in Reward Circuitry from Mothers to Nonfamilial Voices in Adolescence.

The social worlds of young children primarily revolve around parents and caregivers, who play a key role in guiding childrens social and cognitive development. However, a hallmark of adolescence is a shift in orientation toward nonfamilial social targets, an adaptive process that prepares adolescents for their independence. Little is known regarding neurobiological signatures underlying changes in adolescents social orientation. Using functional brain imaging of human voice processing in children and adolescents (ages 7-16), we demonstrate distinct neural signatures for mothers voice and nonfamilial voices across child and adolescent development in reward and social valuation systems, instantiated in nucleus accumbens and ventromedial prefrontal cortex. While younger children showed greater activity in these brain systems for mothers voice compared with nonfamilial voices, older adolescents showed the opposite effect with increased activity for nonfamilial compared with mothers voice. Findings uncover a critical role for reward and social valuative brain systems in the pronounced changes in adolescents orientation toward nonfamilial social targets. Our approach provides a template for examining developmental shifts in social reward and motivation in individuals with pronounced social impairments, including adolescents with autism.SIGNIFICANCE STATEMENT Childrens social worlds undergo a transformation during adolescence. While socialization in young children revolves around parents and caregivers, adolescence is characterized by a shift in social orientation toward nonfamilial social partners. Here we show that this shift is reflected in neural activity measured from reward processing regions in response to brief vocal samples. When younger children hear their mothers voice, reward processing regions show greater activity compared with when they hear nonfamilial, unfamiliar voices. Strikingly, older adolescents show the opposite effect, with increased activity for nonfamilial compared with mothers voice. Findings identify the brain basis of adolescents switch in social orientation toward nonfamilial social partners and provides a template for understanding neurodevelopment in clinical populations with social and communication difficulties

Assessing the Efficacy and Safety of a Digital Therapeutic for Symptoms of Depression in Adolescents: Protocol for a Randomized Controlled Trial

BackgroundDepression is a serious, prevalent, recurrent, and undertreated disorder in adolescents. Low levels of treatment seeking and treatment adherence in this age group, combined with a growing national crisis in access to mental health care, have increased efforts to identify effective treatment alternatives for this demographic. Digital health interventions for mental illness can provide cost-effective, engaging, and accessible means of delivering psychotherapy to adolescents. ObjectiveThis protocol describes a virtual randomized controlled trial designed to evaluate the efficacy and safety of a self-guided, mobile app–based implementation of behavioral activation therapy, SparkRx, for the adjunct treatment of symptoms of depression in adolescents. MethodsParticipants are recruited directly through web-based and print advertisements. Following eligibility screening and consenting, participants are randomly assigned to a treatment arm (SparkRx) or a control arm (assessment-enhanced usual care) for 5 weeks. The primary efficacy outcome, total score on the 8-item Patient Health Questionnaire (PHQ-8), is assessed at the end of the 5-week intervention period. Additional participant-reported outcomes are assessed at baseline, the postintervention time point, and 1-month follow-up. The safety of the intervention is assessed by participant report (and legal guardian report, if the participant is younger than 18 years) and by patterns of symptom deterioration on the PHQ-8, as part of a larger clinical safety monitoring protocol. The primary efficacy outcome, total PHQ-8 score at the postintervention time point, will be compared between SparkRx and enhanced usual care arms using mixed effect modeling, with baseline PHQ-8 and current antidepressant medication status included as covariates. Secondary efficacy outcomes, including the proportion of participants exhibiting treatment response, remission, and minimal clinically significant improvement (all derived from total PHQ-8 scores), will be compared between groups using chi-square tests. Symptom severity at 1-month follow-up will also be compared between arms. Planned subgroup analyses will examine the robustness of treatment effects to differences in baseline symptom severity (PHQ-8 score <15 or ≥ 15) and age (younger than 18 years and older than 18 years). The primary safety outcome, the number of psychiatric serious adverse events, will be compared between trial arms using the Fisher exact test. All other adverse events will be presented descriptively. ResultsAs of May 2023, enrollment into the study has concluded; 223 participants were randomized. The analysis of the efficacy and safety data is expected to be completed by Fall 2023. ConclusionsWe hypothesize that the results of this trial will support the efficacy and safety of SparkRx in attenuating symptoms of depression in adolescents. Positive results would more broadly support the prospect of using accessible, scientifically validated, digital therapeutics in the adjunct treatment of mental health disorders in this age range. Trial RegistrationClinicalTrials.gov NCT05462652; https://clinicaltrials.gov/study/NCT05462652 International Registered Report Identifier (IRRID)DERR1-10.2196/4874