The K20 survey. VI. The Distribution of the Stellar Masses in Galaxies up to z~2

We present a detailed analysis of the stellar mass content of galaxies up to z=2.5 in the K20 galaxy sample, that has a 92% spectroscopic completeness and a complete $UBVRIzJK_s$ multicolor coverage. We find that the M/L ratio decreases with redshift: in particular, the average M/L ratio of early type galaxies decreases with $z$, with a scatter that is indicative of a range of star--formation time-scales and redshift of formation. More important, the typical M/L of massive early type galaxies is larger than that of less massive ones, suggesting that their stellar population formed at higher z. The final K20 galaxy sample spans a range of stellar masses from M*=10^9Msun to M*=10^12Msun, with massive galaxies ($M*>10^11Msun) detected up to z~2. We compute the Galaxy Stellar Mass Function at various z, of which we observe only a mild evolution (i.e. by 20-30%) up to z~1. At z>1, the evolution of the GSMF appears to be much faster: at z~2, about 35% of the present day stellar mass in objects with M*~10^11Msun appear to have assembled. We also detect a change in the physical nature of the most massive galaxies, since at z>1 a population of massive star--forming galaxies progressively appears. We finally analyze our results in the framework of Lambda-CDM hierarchical models. First, we show that the large number of massive galaxies detected at high z does not violate any fundamental Lambda-CDM constraint based on the number of massive DM halos. Then, we compare our results with the predictions of renditions of both semianalytic and hydro-dynamical models, that range from severe underestimates to slight overestimates of the observed mass density at z<~2. We discuss how the differences among these models are due to the different implementation of the main physical processes. (Abridged)Comment: Accepted for publication on Astronomy & Astrophysic

The Development of the INFEWS-ER: A Virtual Resource Center for Transdisciplinary Graduate Student Training at the Nexus of Food, Energy, and Water

Problems at the nexus of Food, Energy and Water Systems (FEWS) are among the most complex challenges we face. Spanning simple to complex temporal, geographic, social, and political framings, the questions raised at this nexus require multidisciplinary if not transdisciplinary approaches. Answers to these questions must draw from engineering, the physical and biological sciences, and the social sciences. Practical solutions depend upon a wide community of stakeholders, including industry, policymakers, and the general public. Yet there are many obstacles to working in a transdisciplinary environment: unfamiliar concepts, specialized terminology, and countless “blind” spots. Graduate education occurs in disciplinary ‘silos’, often with little regard for the unintended consequences of our research. Existing pedagogicalmodels do not usually train students to understand neighboring disciplines, thus limiting student learning to narrow areas of expertise, and obstructing their potential for transdisciplinary discourse over their careers. Our goal is a virtual resource center—the INFEWS-ER—that provides educational opportunities to supplement graduate students, especially in their development of transdisciplinary competences. Addressing the grand challenges at the heart of the FEWS nexus will depend upon such competence. Students and scholars from diverse disciplines are working together to develop the INFEWS-ER. To date, we have sponsored both a workshop and a symposium to identify priorities to design the initial curriculum. We have also conducted surveys of the larger community of FEWS researchers. Our work confirms a widespread interest in transdisciplinary training and helps to identify core themes and promising pedagogical approaches. Our curriculum now centers upon several “Cohort Challenges,” supported by various “Toolbox Modules” organized around key themes (e.g., communicating science). We plan to initiate the first cohort of students in October of 2018. Students who successfully complete their Cohort Challenges will be certified as the FEW Graduate Scholars. In this paper, we describe the development of this curriculum. We begin with the need for training in transdisciplinary research. We then describe the workshop and symposium, as well as our survey results. We conclude with an outline of the curriculum, including the current Cohort Challenges and Toolbox Modules

The Development of the INFEWS-ER: A Virtual Resource Center for Transdisciplinary Graduate Student Training at the Nexus of Food, Energy, and Water

Problems at the nexus of Food, Energy and Water Systems (FEWS) are among the most complex challenges we face. Spanning simple to complex temporal, geographic, social, and political framings, the questions raised at this nexus require multidisciplinary if not transdisciplinary approaches. Answers to these questions must draw from engineering, the physical and biological sciences, and the social sciences. Practical solutions depend upon a wide community of stakeholders, including industry, policymakers, and the general public. Yet there are many obstacles to working in a transdisciplinary environment: unfamiliar concepts, specialized terminology, and countless “blind” spots. Graduate education occurs in disciplinary ‘silos', often with little regard for the unintended consequences of our research. Existing pedagogical models do not usually train students to understand neighboring disciplines, thus limiting student learning to narrow areas of expertise, and obstructing their potential for transdisciplinary discourse over their careers. Our goal is a virtual resource center—the INFEWS-ER—that provides educational opportunities to supplement graduate students, especially in their development of transdisciplinary competences. Addressing the grand challenges at the heart of the FEWS nexus will depend upon such competence. Students and scholars from diverse disciplines are working together to develop the INFEWS-ER. To date, we have sponsored both a workshop and a symposium to identify priorities to design the initial curriculum. We have also conducted surveys of the larger community of FEWS researchers. Our work confirms a widespread interest in transdisciplinary training and helps to identify core themes and promising pedagogical approaches. Our curriculum now centers upon several “Cohort Challenges,” supported by various “Toolbox Modules” organized around key themes (e.g., communicating science). We plan to initiate the first cohort of students in October of 2018. Students who successfully complete their Cohort Challenges will be certified as the FEW Graduate Scholars. In this paper, we describe the development of this curriculum. We begin with the need for training in transdisciplinary research. We then describe the workshop and symposium, as well as our survey results. We conclude with an outline of the curriculum, including the current Cohort Challenges and Toolbox Modules

Vasoconstrictor effect of the angiotensin converting enzyme resistant chymase substrate [Pro11 D-Ala12] angiotensin I in human dorsal hand veins: In vivo demonstration of non ACE conversion of angiotensin II in humans

Background: [Pro11D-Ala12] angiotensin I is an ACE-resistant substrate specific for chymase. We used this peptide to determine whether a functionally significant non-ACE angiotensin (Ang) II–generating pathway exists in human dorsal hand veins.&lt;p&gt;&lt;/p&gt; Methods and Results: Using a modified Aellig technique, we studied the response to Ang I and [Pro11D-Ala12] Ang I in dorsal hand veins in vivo in patients with coronary heart disease. We measured the venoconstrictor effect of each peptide given before and after a 6.25-mg oral dose of the ACE inhibitor captopril or matching placebo. Placebo or captopril was given in a double-blind, randomized fashion. Ang I induced a mean±SEM venoconstrictor response of 45±11%, 40±10%, 55±8%, and 4±4% before placebo, after placebo, before captopril, and after captopril, respectively. Hence, the response to Ang I was reproducible and was reduced significantly only after treatment with captopril (P=0.002). [Pro11D-Ala12] Ang I induced a mean venoconstrictor response of 42±9%, 49±9%, 48±10%, and 54±11% before placebo, after placebo, before captopril, and after captopril, respectively. Hence, captopril had no significant effect on the response to [Pro11D-Ala12] Ang I.&lt;p&gt;&lt;/p&gt; Conclusions: We have demonstrated that [Pro11D-Ala12] Ang I is able to induce venoconstriction in humans in vivo. With this specific pharmacological probe, we have shown that a non-ACE pathway capable of generating Ang II exists in human veins in vivo and is potentially functionally important. This pathway is likely to involve the enzyme chymase

The Development of the INFEWS-ER: A Virtual Resource Center for Transdisciplinary Graduate Student Training at the Nexus of Food, Energy, and Water

Problems at the nexus of Food, Energy and Water Systems (FEWS) are among the most complex challenges we face. Spanning simple to complex temporal, geographic, social, and political framings, the questions raised at this nexus require multidisciplinary if not transdisciplinary approaches. Answers to these questions must draw from engineering, the physical and biological sciences, and the social sciences. Practical solutions depend upon a wide community of stakeholders, including industry, policymakers, and the general public. Yet there are many obstacles to working in a transdisciplinary environment: unfamiliar concepts, specialized terminology, and countless “blind” spots. Graduate education occurs in disciplinary ‘silos’, often with little regard for the unintended consequences of our research. Existing pedagogicalmodels do not usually train students to understand neighboring disciplines, thus limiting student learning to narrow areas of expertise, and obstructing their potential for transdisciplinary discourse over their careers. Our goal is a virtual resource center—the INFEWS-ER—that provides educational opportunities to supplement graduate students, especially in their development of transdisciplinary competences. Addressing the grand challenges at the heart of the FEWS nexus will depend upon such competence. Students and scholars from diverse disciplines are working together to develop the INFEWS-ER. To date, we have sponsored both a workshop and a symposium to identify priorities to design the initial curriculum. We have also conducted surveys of the larger community of FEWS researchers. Our work confirms a widespread interest in transdisciplinary training and helps to identify core themes and promising pedagogical approaches. Our curriculum now centers upon several “Cohort Challenges,” supported by various “Toolbox Modules” organized around key themes (e.g., communicating science). We plan to initiate the first cohort of students in October of 2018. Students who successfully complete their Cohort Challenges will be certified as the FEW Graduate Scholars. In this paper, we describe the development of this curriculum. We begin with the need for training in transdisciplinary research. We then describe the workshop and symposium, as well as our survey results. We conclude with an outline of the curriculum, including the current Cohort Challenges and Toolbox Modules

Essential hypertension and beta(2)-adrenergic receptor gene linkage and association analysis

A region on human chromosome 5 (5q31.1-qter) contains several genes that encode important blood pressure regulators and thus is a good candidate for analysis of linkage and association with hypertension. We recruited 638 individuals from 212 Polish pedigrees with clustering of essential hypertension. These subjects were genotyped for I I microsatellite markers that span this region to test for linkage to essential hypertension and systolic and diastolic blood pressures. The segment of this region of approximate to7 cM delineated by D5S1480 and D5S500 markers was linked to blood pressures in multipoint analysis. In 2-point analysis, D5S1480-the marker in close proximity to beta(2)-adrenergic receptor gene-reached the maximal linkage to essential hypertension and adjusted systolic and diastolic blood pressures, implicating this gene as a positional candidate for further association studies. Arg16Gly, Gln27GIu, and Thr164Ile-3 functional single nucleotide polymorphisms within the beta(2)-adrenergic receptor gene-were tested for association with essential hypertension. None of these polymorphisms showed a significant association with essential hypertension, separately or in the haplotype analysis. This study provided evidence of linkage of 5q31.1-5qter region to essential hypertension in the European population. Moreover, it implicated the chromosomal segment in close proximity to D5S1480 and D5S500. The detailed analysis of 3 single nucleotide polymorphisms does not support the role of the beta(2)-adrenergic receptor gene as a major causative gene for the detected linkage

The Development of the INFEWS-ER: A Virtual Resource Center for Transdisciplinary Graduate Student Training at the Nexus of Food, Energy, and Water

Problems at the nexus of Food, Energy and Water Systems (FEWS) are among the most complex challenges we face. Spanning simple to complex temporal, geographic, social, and political framings, the questions raised at this nexus require multidisciplinary if not transdisciplinary approaches. Answers to these questions must draw from engineering, the physical and biological sciences, and the social sciences. Practical solutions depend upon a wide community of stakeholders, including industry, policymakers, and the general public. Yet there are many obstacles to working in a transdisciplinary environment: unfamiliar concepts, specialized terminology, and countless “blind” spots. Graduate education occurs in disciplinary ‘silos', often with little regard for the unintended consequences of our research. Existing pedagogical models do not usually train students to understand neighboring disciplines, thus limiting student learning to narrow areas of expertise, and obstructing their potential for transdisciplinary discourse over their careers. Our goal is a virtual resource center—the INFEWS-ER—that provides educational opportunities to supplement graduate students, especially in their development of transdisciplinary competences. Addressing the grand challenges at the heart of the FEWS nexus will depend upon such competence. Students and scholars from diverse disciplines are working together to develop the INFEWS-ER. To date, we have sponsored both a workshop and a symposium to identify priorities to design the initial curriculum. We have also conducted surveys of the larger community of FEWS researchers. Our work confirms a widespread interest in transdisciplinary training and helps to identify core themes and promising pedagogical approaches. Our curriculum now centers upon several “Cohort Challenges,” supported by various “Toolbox Modules” organized around key themes (e.g., communicating science). We plan to initiate the first cohort of students in October of 2018. Students who successfully complete their Cohort Challenges will be certified as the FEW Graduate Scholars. In this paper, we describe the development of this curriculum. We begin with the need for training in transdisciplinary research. We then describe the workshop and symposium, as well as our survey results. We conclude with an outline of the curriculum, including the current Cohort Challenges and Toolbox Modules.This article is published as Rodríguez, Luis F., Anna-Maria Marshall, Dan Cotton, Richard Koelsch, Jacek Koziel, Deanne Meyer, Dan Steward, Jill Heemstra, Anand Padmanabahn, John Classen, Nathan J. Meyer, Benjamin L. Ruddell, Sean M. Ryan, Ximing Cai, Emad Habib, and Peter D. Saundry. "The Development of the INFEWS-ER: A Virtual Resource Center for Transdisciplinary Graduate Student Training at the Nexus of Food, Energy, and Water." Frontiers in Environmental Science 7 (2019): 38. DOI: 10.3389/fenvs.2019.00038. Posted with permission.</p

The Global Ambulatory Blood Pressure Monitoring (ABPM) in Heart Failure with Preserved Ejection Fraction (HFpEF) Registry: Rationale, design and objectives

Hypertension is a major risk factor for the development of heart failure with preserved ejection fraction (HFPEF) and blood pressure (BP) in itself is an important marker of prognosis. The association of BP levels, and hemodynamic parameters, measured by ambulatory blood pressure monitoring (ABPM), with outcomes, in patients with HFPEF is largely unknown. Patients with HFPEF have a substantial burden of co-morbidities and frailty. In addition there are marked geographic differences in HFPEF around the world. How these difference influence the association between BP and outcomes in HFPEF are unknown. The Global Ambulatory Blood Pressure Monitoring (ABPM) in Heart Failure with Preserved Ejection Fraction (HFpEF) Registry aims to assess the relevance of BP parameters, measured by ABPM, on the outcome of HFPEF patients worldwide. Additionally, the influence of other relevant factors such as frailty and co-morbidities will be assessed. Stable HFPEF patients with a previous hospitalization, will be included. Patients should be clinically and hemodynamically stable for at least 4 weeks before study inclusion. Specific data related to HF, biochemical markers, ECG and echocardiography will be collected. An ABPM and geriatric and frailty evaluation will be performed and the association with morbidity and mortality assessed. Follow up will be at least one year.Fil: Camafort Babkowski, Miguel. Universidad de Barcelona; EspañaFil: Adeseye, Akintunde. Ladoke Akintola University Of Technology; NigeriaFil: Coca, Antonio. Universidad de Barcelona; EspañaFil: Damasceno, Albertino. Eduardo Mondlane University; Estados UnidosFil: De Simone, Giovanni. Università degli Studi di Napoli Federico II; ItaliaFil: Dorobantu, Maria. University Emergency Hospital Bucharest; RumaniaFil: Jhund, Pardeep S.. Glasgow Cardiovascular Research Centre; Reino UnidoFil: Kario, Kazuomi. Jichi Medical University; JapónFil: Komori, Takahiro. Jichi Medical University; JapónFil: Lee, Hae young. Seoul National University College Of Medicine; Corea del SurFil: López Jaramillo, Patricio. Universidad Industrial Santander; ColombiaFil: Ogah, Okechukwu. University College Hospital; NigeriaFil: Padmanabahn, Sandosh. Glasgow Cardiovascular Research Centre; Reino UnidoFil: Pascual Figal, Domingo A.. Hospital Virgen de la Arrixaca; EspañaFil: Pyun, Wook Bum. Ewha Womans University; Corea del SurFil: Renna, Nicolas Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universida Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaFil: Barroso, Weimar Kunz Sebba. Universidade Federal de Goiás; BrasilFil: Valdez Tiburcio, Osiris. Centro de Especialidades Médicas Romana; República DominicanaFil: Wyss Quintana, Fernando Stuardo. Servicios y Tecnología Cardiovascularç; Guatemal