Thermo-compositional diabatic convection in the atmospheres of brown dwarfs and in Earth's atmosphere and oceans

This is the author accepted manuscript. The final version is available from the American Astronomical Society / IOP Publishing via the DOI in this record.The simulation outputs are available at http://opendata.erc-atmo.euBy generalizing the theory of convection to any type of thermal and compositional source terms (diabatic processes), we show that thermohaline convection in Earth oceans, fingering convection in stellar atmospheres, and moist convection in Earth atmosphere are deriving from the same general diabatic convective instability. We show also that "radiative convection" triggered by CO/CH4 transition with radiative transfer in the atmospheres of brown dwarfs is analog to moist and thermohaline convection. We derive a generalization of the mixing length theory to include the effect of source terms in 1D codes. We show that CO/CH4 radiative convection could significantly reduce the temperature gradient in the atmospheres of brown dwarfs similarly to moist convection in Earth atmosphere thus possibly explaining the reddening in brown-dwarf spectra. By using idealized two-dimensional hydrodynamic simulations in the Ledoux unstable regime, we show that compositional source terms can indeed provoke a reduction of the temperature gradient. The L/T transition could be explained by a bifurcation between the adiabatic and diabatic convective transports and could be seen as a giant cooling crisis: an analog of the boiling crisis in liquid/steam-water convective flows. This mechanism with other chemical transitions could be present in many giant and earth-like exoplanets. The study of the impact of different parameters (effective temperature, compositional changes) on CO/CH4 radiative convection and the analogy with Earth moist and thermohaline convection is opening the possibility to use brown dwarfs to better understand some aspects of the physics at play in the climate of our own planet.Science and Technology Facilities Council (STFC

Laser Ultrasonic Inspection of Graphite Epoxy Laminates

Superior mechanical properties and reduced weight of fiber reinforced polymer matrix composite laminates (e.g., made of graphite epoxy) are leading to their increased use in aeronautic and aerospace structures. These materials are found more and more in load bearing components, which in turn, requires their integrity to be fully evaluated by nondestructive inspection. This applies to newly manufactured parts which can be flawed following improper manufacturing procedures and to parts which have been in service on an aircraft as well, since additional flaws could have occurred and old existing flaws could have grown and become more severe. Flaws which are found in these materials include porosity and foreign inclusions, which are produced during manufacturing and delaminations between plies, which can be produced at manufacturing or can be caused by the impact of foreign objects on the structure. Ultrasonics has been recognized to be a superior technique for detecting delaminations and can be used to detect foreign inclusions and assess porosity, as well [1,2]. The ultrasonic waves are usually generated and detected by piezoelectric transducers and coupled to the inspected part by direct contact or water. Although operation in transmission is widely used and easily implemented for curved parts, the pulse-echo mode is preferred since it requires only single side access and provides flaw depth information. In this case, the transducer should be properly aligned with respect to the surface of the inspected part (within a few degrees), since it is a phase sensitive device emitting and its whole surfacePeer reviewed: YesNRC publication: Ye

Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription.

DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regulation, we quantified allelic variability in transcription factor binding, histone modifications, and gene expression within humans. We found abundant allelic specificity in chromatin and extensive local, short-range, and long-range allelic coordination among the studied molecular phenotypes. We observed genetic influence on most of these phenotypes, with histone modifications exhibiting strong context-dependent behavior. Our results implicate transcription factors as primary mediators of sequence-specific regulation of gene expression programs, with histone modifications frequently reflecting the primary regulatory event

Symposium on the Scottish labour market

In the post-war period, up to the late 1960s, Britain enjoyed a modicum of unemployment and government policies which were geared to producing Full Employment were considered a success. It was simple - boost demand and more people would find work. But the mid 1970s the economic regency enjoyed by those advocating demand sided policies fell into disrepute as the OPEC nations raised prices dramatically and brought in a new era of both rising prices and unemployment. The laws of economics, which previously had viewed policy decisions as the choice between lower unemployment and higher inflation were now redundant. Both unemployment and inflation were moving in the same direction. The era of stagflation had begun

Transcriptome and genome sequencing uncovers functional variation in humans

Summary Genome sequencing projects are discovering millions of genetic variants in humans, and interpretation of their functional effects is essential for understanding the genetic basis of variation in human traits. Here we report sequencing and deep analysis of mRNA and miRNA from lymphoblastoid cell lines of 462 individuals from the 1000 Genomes Project – the first uniformly processed RNA-seq data from multiple human populations with high-quality genome sequences. We discovered extremely widespread genetic variation affecting regulation of the majority of genes, with transcript structure and expression level variation being equally common but genetically largely independent. Our characterization of causal regulatory variation sheds light on cellular mechanisms of regulatory and loss-of-function variation, and allowed us to infer putative causal variants for dozens of disease-associated loci. Altogether, this study provides a deep understanding of the cellular mechanisms of transcriptome variation and of the landscape of functional variants in the human genome