A proteomic focus of the alterations occurring at the human atherosclerotic coronary intima and media

Comunicaciones a congreso

Estudio de la Estenosis Aórtica Valvular desde un punto de vista proteómico

Comunicaciones a congreso

Identification of protein expressed by aortic stenosis valves in the search for novel biomarkers

Comunicaciones a congreso

Proteomics: a poweful tool to deepen the molecular mechanisms of ischemic stroke

Comunicaciones a congreso

The Influence of Coronary Artery Disease in the Development of Aortic Stenosis and the Importance of the Albumin Redox State.

Calcific aortic valve and coronary artery diseases are related cardiovascular pathologies in which common processes lead to the calcification of the corresponding affected tissue. Among the mechanisms involved in calcification, the oxidative stress that drives the oxidation of sulfur-containing amino acids such ascysteines is of particular interest. However, there are important differences between calcific aortic valve disease and coronary artery disease, particularly in terms of the reactive oxygen substances and enzymes involved. To evaluate what effect coronary artery disease has on aortic valves, we analyzed valve tissue from patients with severe calcific aortic stenosis with and without coronary artery disease. Proteins and peptides with oxidized cysteines sites were quantified, leading to the identification of 16 proteins with different levels of expression between the two conditions studied, as well as differences in the redox state of the tissue. We also identified two specific sites of cysteine oxidation in albumin that have not been described previously. These results provide evidence that coronary artery disease affects valve calcification, modifying the molecular profile of aortic valve tissue. In addition, the redox proteome is also altered when these conditions coincide, notably affecting human serum albumin.This research was funded by the Junta de Comunidades de Castilla-La Mancha (JCCM, co-funded by the European Social Fund, SBPLY/19/180501/000226), the Instituto de Salud Carlos III through the project PI18/00995, PI21/00384 (co-funded by European Regional Development Fund/European Social Fund—“Investing in your future”) Sociedad Española de Cardiología, 2020, Grant PRB3 (IPT17/0019—ISCIII-SGEFI/ERDF), Spanish Ministry of Science, Innovation and Universities (PGC2018-097019-B-I00) and “la Caixa” Banking Foundation (project code HR17-00247). These results are aligned with the Spanish initiative on the Human Proteome Project (SpHPP).S

Consecuencias en la competencia digital del alumnado de primaria de un programa de educación física usando la metodología ABP

Presentamos en esta investigación el efecto que causó en el desarrollo de la competencia digital una intervención desde el área de Educación física a través de la metodología ABP (Aprendizaje Basado en Proyectos). La muestra consistió en 38 niñas y 37 niños de sexto de Educación Primaria, y la intervención se desarrolló durante el curso escolar 2014/15. Se utilizó un método de Investigación-Acción, analizando el diario del maestro, el cuestionario al alumnado y una entrevista semiestructurada con las diferentes opiniones del alumnado. Los resultados confirman que el alumnado incrementó su conocimiento y motivación en la competencia digital a nivel interdisciplinar con el uso de dicha metodología

Hacia un completo entendimiento de la fisiopatología del síndrome coronario agudo mediante la combinación de estudios proteómicos y metabolómicos

Comunicaciones a congreso

Proteomic analysis of intimal layer from human coronary atherothrombotic arteries

Comunicaciones a congreso