15 research outputs found
Ajtószárny lebenyek speciális felhasználási lehetőségei fej-nyaki tumoros beteganyagunkon = Application alternatives of turnover flaps in special cases of head and neck cancer
Correlation between fibroblast growth factor receptor mutation, programmed death ligand-1 expression and survival in urinary bladder cancer based on real-world data
Challenges in the complex management of neglected cutaneous melanomas in the head and neck area: a single center experience
Familiar controversies in the management of head and neck melanomas are more remarkable in locally advanced cases, and they represent a treatment challenge both surgically and oncologically. In our retrospective study, patients with surgically treated primary malignant melanoma of the head and neck region larger than 3 cm in diameter were included. Five patients met our inclusion criteria. In all cases, wide excision and immediate reconstruction were performed without sentinel lymph node biopsy. The defect on the scalp was covered by a split skin graft, with local flaps chosen for reconstruction on the face on an individual basis. After a 2–6 year follow-up, a good oncological, functional, and esthetic result was achieved. Our results show that in the case of large, locally advanced melanomas, surgical treatment still plays a crucial role that can provide long-term local control and support the effect of systemic treatment
Prostate-specific membrane antigen-based imaging for stereotactic irradiation of low-volume progressive prostate cancer: a single-center experience
Comprehensive deep learning-based framework for automatic organs-at-risk segmentation in head-and-neck and pelvis for MR-guided radiation therapy planning
Minimally invasive endo-laryngo-microsurgery for precancerosis and early cancer of the vocal cords, and a new diagnostic laryngoscopy and surgical training device
Epithelialis-myoepithelialis carcinoma nyelvgyöki lokalizációja – esetismertetés és irodalmi áttekintés
A nyelv ritka, benignus, ectomesenchymalis chondromyxoid tumora
Absztrakt:
Az ectomesenchymalis chondromyxoid tumor a szájüreg igen ritka benignus
lágyrész-daganata, napjainkig mindösszesen 93 esetet közöltek a nemzetközi
szakirodalomban. Klinikailag csaknem kizárólag a nyelvhát elülső harmadában
alakul ki, lassan növekvő, változatos nagyságú, fájdalmatlan, tömött, submucosus
csomó formájában jelentkezik. A tumort szövetileg myxoid/chondromyxoid stromában
hálózatos szerkezetbe rendeződött, kerek, poligonális vagy orsó alakú sejtek
építik fel. Habár a megjelenés nagyban hasonlít a bőr és a lágyrészek
myoepitheliomájára, a hisztogenezis máig nem tisztázott, azonban egy újabban
megjelent, nagy esetszámot tartalmazó közlemény RREB1-MKL2
génfúziót igazolt az esetek 90%-ában, ami a daganat önálló entitását
bizonyíthatja. A pontos szövettani diagnózis felállítását az immunhisztokémiai
vizsgálatok biztosítják. Közleményünkben egy 62 éves férfi betegünk esetét
mutatjuk be, aki a nyelvcsúcsán észlelt egy 3 cm nagyságú, fájdalmatlan, lassan
növekvő csomót. A tervezett műtéti beavatkozáson nem jelent meg, csak 4 évvel
később jelentkezett ismét, ekkorra a sebészi kezelésbe már beleegyezett. A
daganat eltávolítását követően 24 hónappal panaszmentes, lokális recidíva nem
észlelhető. Orv Hetil. 2019; 160(33): 1319–1323.
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Abstract:
Ectomesenchymal chondromyxoid tumor is a rare benign intraoral soft tissue
neoplasm. Till date, 93 cases have been reported in literature. Clinically, it
presents as a slowly growing, painless, firm, submucosal swelling mainly
occurring on the anterior two thirds of the dorsum of the tongue.
Histopathologically, the tumor is characterized by a well circumscribed, lobular
proliferation of round, polygonal, or fusiform cells in a net-like pattern in a
myxoid to chondromyxoid background. Although it shows a morphological
resemblance to myoepitheliomas of soft tissue and skin, the exact histogenesis
remains unclear; a recent publication of a large series has demonstrated
recurrent RREB1-MKL2 gene fusions in 90% of the cases,
suggesting the possibility of a new entity. The diagnosis is largely supported
by immunhistochemical investigations. Here, we present a new case of ECT
occurring in a 62-year-old male who presented with a leading complaint of slowly
growing painless mass arising from the anterior part of the tongue measuring
about 3 cm. This lesion was diagnosed 4 years before recent admittance, but the
patient did not undergo the scheduled surgical intervention and was lost to
follow-up. As the tumor was still persisting and moderately enlarging, he came
back to our clinic. Finally, the mass was completely resected; after 24 month of
follow-up, he is doing well, with no signs of recurrence. Orv Hetil. 2019;
160(33): 1319–1323