T-duality for principal torus bundles

In this paper we study T-duality for principal torus bundles with H-flux. We identify a subset of fluxes which are T-dualizable, and compute both the dual torus bundle as well as the dual H-flux. We briefly discuss the generalized Gysin sequence behind this construction and provide examples both of non T-dualizable and of T-dualizable H-fluxes.Comment: 9 pages, typos removed and minor corrections mad

Utilização de transformações não-parametricas no ajuste de dados de contagem de carrapatos utilizados no mapeamento de QTL.

Boophilus microplus; Carraptados; Mapeamento de QTL; Dado

Mapping quantitative trait loci in Gallus gallus using principal components.

Projeto/Plano de Ação: 01.06.10.602-03

Patterns in Age-Seroprevalence Consistent with Acquired Immunity against Trypanosoma brucei in Serengeti Lions

Trypanosomes cause disease in humans and livestock throughout sub-Saharan Africa. Although various species show evidence of clinical tolerance to trypanosomes, until now there has been no evidence of acquired immunity to natural infections. We discovered a distinct peak and decrease in age prevalence of T. brucei s.l. infection in wild African lions that is consistent with being driven by an exposure-dependent increase in cross-immunity following infections with the more genetically diverse species, T. congolense sensu latu. The causative agent of human sleeping sickness, T. brucei rhodesiense, disappears by 6 years of age apparently in response to cross-immunity from other trypanosomes, including the non-pathogenic subspecies, T. brucei brucei. These findings may suggest novel pathways for vaccinations against trypanosomiasis despite the notoriously complex antigenic surface proteins in these parasites

Patterns in Age-Seroprevalence Consistent with Acquired Immunity against Trypanosoma brucei in Serengeti Lions

Trypanosomes cause disease in humans and livestock throughout sub-Saharan Africa. Although various species show evidence of clinical tolerance to trypanosomes, until now there has been no evidence of acquired immunity to natural infections. We discovered a distinct peak and decrease in age prevalence of T. brucei s.l. infection in wild African lions that is consistent with being driven by an exposure-dependent increase in cross-immunity following infections with the more genetically diverse species, T. congolense sensu latu. The causative agent of human sleeping sickness, T. brucei rhodesiense, disappears by 6 years of age apparently in response to cross-immunity from other trypanosomes, including the non-pathogenic subspecies, T. brucei brucei. These findings may suggest novel pathways for vaccinations against trypanosomiasis despite the notoriously complex antigenic surface proteins in these parasites

On twisted Fourier analysis and convergence of Fourier series on discrete groups

We study norm convergence and summability of Fourier series in the setting of reduced twisted group $C^*$-algebras of discrete groups. For amenable groups, F{\o}lner nets give the key to Fej\'er summation. We show that Abel-Poisson summation holds for a large class of groups, including e.g. all Coxeter groups and all Gromov hyperbolic groups. As a tool in our presentation, we introduce notions of polynomial and subexponential H-growth for countable groups w.r.t. proper scale functions, usually chosen as length functions. These coincide with the classical notions of growth in the case of amenable groups.Comment: 35 pages; abridged, revised and update

Mapeamento de QTL para resistência a carrapatos no cromossomo 23 de bovinos (BTA23).

Uma população experimental F2 de bovinos, originada do cruzamento das raças Gir x Holandês, foi genotipada para o cromossomo 23 (BTA23) utilizando cinco marcadores microssatélites distribuídos ao longo dos cromossomos, com um espaçamento médio de 25 cM entre eles. Os marcadores utilizados foram BM1258, BM1818, BM1905, BB705 e CSSM24, com os quais foi construído um mapa de ligação para o BTA23. Dessa população F2, 263 animais foram submetidos a infestação artificial pelo carrapato Boophilus microplus. Vinte e um dias após a infestação, foi contado o número de carrapatos (larvas engurgitadas) presentes em cada animal. Dois modelos estatísticos foram desenvolvidos com o auxílio do programa SAS para análise da variância e para fins de mapeamento de QTL, o primeiro modelo incluía como efeitos fixos a avaliação dos animais quanto à cor da pelagem (100% branca, mais de 75%, entre 50 a 75% e entre 25 a 50%), tipo de pêlo (curto liso, curto lanado, longo liso e longo lanado) e sexo e como covariáveis idade à infestação e estação (águas e seca); no outro modelo a covariável estação foi eliminada. As medidas da contagem de carrapatos foram submetidas a várias transformações, entre elas a raiz quadrada e logaritmo, sendo que o logaritmo da contagem de carrapatos foi a mais adequada no sentido de remover a heterogeneidade das variâncias e promover normalidade. O mapeamento de QTL foi realizado pelo programa QTL Express (Seaton et al., 2002), considerando ou não as interações entre QTL e sexo, e entre QTL e estação. Foi encontrado, no cromossomo 23, um indício de QTL no modelo aditivo (p < 0,08) com interação com tipo de pelagem na posição de 24 cM, porém de pequeno efeito no aumento do numero de carrapatos (explicando 3,29% da variância fenotipica) e de origem na raça Holandês. Outro QTL sugestivo foi encontrado no modelo aditivo (p < 0,05) com interação com sexo na posição 89 cM, também de pequeno efeito (explicando 3,18% da variância fenotipica) com a mesma origem do anterior. Ambos QTL foram encontrados utilizando-se o modelo contendo a covariável estação. Isso mostra que o tipo de pelagem e o sexo do animal possuem influência em sua carga parasitária. Observou-se também uma melhora no poder do teste para detecção de QTL quando a covariável estação é retirada da análise no caso da interação do QTL com sexo, o mesmo não ocorre na interação com tipo de pelagem. Estes resultados preliminares justificam a realização de pesquisas adicionais no sentido de identificar os fatores relacionados a resistência genética de bovinos ao carrapato

Come for the looks, stay for the personality? A mixed methods investigation of reacquisition and owner recommendation of Bulldogs, French Bulldogs and Pugs

Brachycephalic breeds are proliferating internationally, with dramatic rises in popularity juxtaposed with common and severe breed-related health problems. Physical appearance is as a dominant factor attracting owners to brachycephalic breeds; however, whether these owners will choose their current breed for future ownership and develop 'breed-loyalty' in the face of health problems is not yet known. The aims of this study were (1) to quantify levels of, and explore factors associated with, brachycephalic dog owners' intentions to: (i) reacquire and/or (ii) recommend their current breed to potential first-time dog owners, and (2) to use qualitative methods to explore why brachycephalic dog owners would or would not recommend their current breed. This large mixed methods study reports on 2168 owners of brachycephalic breeds (Pugs: n = 789; French Bulldog: n = 741; Bulldogs: n = 638). Owners were highly likely to want to own their breed again in the future (93.0%) and recommend their breed to other owners (65.5%). Statistical modelling identified that first-time ownership and increased strength of the dog-owner relationship increased the likelihood of reacquisi-tion and/or recommendation. In contrast, an increased number of health problems, positive perception of their dog's health compared with the rest of their breed, and dog behaviour being worse than expected decreased the likelihood of reacquisition and/or recommendation. Thematic analyses constructed three themes describing why owners recommend their breed: positive behavioural attributes for a companion dog, breed suited to a sedentary lifestyle with limited space, and suitability for households with children. Five themes described why owners recommended against their breed: high prevalence of health problems, expense of ownership, ethical and welfare issues associated with breeding brachycephalic dogs, negative effects upon owner lifestyle and negative behavioural attributes. Understanding how breed-loyalty develops, and whether it can be attenuated, will be key to controlling the current population boom in brachycephalic breeds in the long-term

Epidemiological associations between brachycephaly and upper respiratory tract disorders in dogs attending veterinary practices in England

Background: Brachycephalic dog breeds are increasingly common. Canine brachycephaly has been associated with upper respiratory tract (URT) disorders but reliable prevalence data remain lacking. Using primary-care veterinary clinical data, this study aimed to report the prevalence and breed-type risk factors for URT disorders in dogs. Results: The sampling frame included 170,812 dogs attending 96 primary-care veterinary clinics participating within the VetCompass Programme. Two hundred dogs were randomly selected from each of three extreme brachycephalic breed types (Bulldog, French Bulldog and Pug) and three common small-to medium sized breed types (moderate brachycephalic: Yorkshire Terrier and non-brachycephalic: Border Terrier and West Highland White Terrier). Information on all URT disorders recorded was extracted from individual patient records. Disorder prevalence was compared between groups using the chi-squared test or Fisher’s test, as appropriate. Risk factor analysis used multivariable logistic regression modelling. During the study, 83 (6.9 %) study dogs died. Extreme brachycephalic dogs (median longevity: 8.6 years, IQR: 2.4-10.8) were significantly younger at death than the moderate and non-brachycephalic group of dogs (median 12.7 years, IQR 11.1-15.0) (P \u3c 0.001). A higher proportion of deaths in extreme brachycephalic breed types were associated with URT disorders (4/24 deaths, 16.7 %) compared with the moderate and non-brachycephalic group (0/59 deaths, 0.0 %) (P = 0.001). The prevalence of having at least one URT disorder in the extreme brachycephalic group was higher (22.0 %, 95 % confidence interval (CI): 18.0-26.0) than in the moderate and non-brachycephalic group (9.7 %, 95 % CI: 7.1-12.3, P \u3c 0.001). The prevalence of URT disorders varied significantly by breed type: Bulldogs 19.5 %, French Bulldogs 20.0 %, Pugs 26.5 %, Border Terriers 9.0 %, West Highland White Terriers 7.0 % and Yorkshire Terriers 13.0 % (P \u3c 0.001). After accounting for the effects of age, bodyweight, sex, neutering and insurance, extreme brachycephalic dogs had 3.5 times (95 % CI: 2.4-5.0, P \u3c 0.001) the odds of at least one URT disorder compared with the moderate and non-brachycephalic group. Conclusions: In summary, this study reports that URT disorders are commonly diagnosed in Bulldog, French Bulldog, Pug, Border Terrier, WHWT and Yorkshire Terrier dogs attending primary-care veterinary practices in England. The three extreme brachycephalic breed types (Bulldog, French Bulldog and Pug) were relatively short-lived and predisposed to URT disorders compared with three other small-to-medium size breed types that are commonly owned (moderate brachycephalic Yorkshire Terrier and non-brachycephalic: Border Terrier and WHWT). Conclusions: In summary, this study reports that URT disorders are commonly diagnosed in Bulldog, French Bulldog, Pug, Border Terrier, WHWT and Yorkshire Terrier dogs attending primary-care veterinary practices in England. The three extreme brachycephalic breed types (Bulldog, French Bulldog and Pug) were relatively short-lived and predisposed to URT disorders compared with three other small-to-medium size breed types that are commonly owned (moderate brachycephalic Yorkshire Terrier and non-brachycephalic: Border Terrier and WHWT)