Cardiorespiratory Coupling in Asthmatic Children

The relationship between cardiac and respiratory autonomic control has been suggested to be altered in several respiratory disorders. However, and despite the increasing prevalence of asthma, there are not studies assessing the cardiorespiratory coupling (CRC) with respect to the asthmatic status. Since altered autonomic control has been suggested to play a major role in asthma, in this work overnight CRC was assessed in a group of 67 children who underwent a three-month inhaled corticosteroids treatment. After treatment completion, CRC was reduced (p < 0.005) in the subjects without or with a low risk of asthma, whereas it kept unchanged in those with a worse prognosis, suggesting that an altered interaction between cardiac and respiratory activity might be related with an increased risk of asthma

Noninvasive Cardiorespiratory Signals Analysis for Asthma Evolution Monitoring in Preschool Children

OBJECTIVE: Despite its increasing prevalence, diagnosis of asthma in children remains problematic due to their difficulties in producing repeatable spirometric maneuvers. Moreover, low adherence to inhaled corticosteroids (ICS) treatment could result in permanent airway remodeling. The growing interest in a noninvasive and objective way for monitoring asthma, together with the apparent role of autonomic nervous system (ANS) in its pathogenesis, have attracted interest towards heart rate variability (HRV) and cardiorespiratory coupling (CRC) analyses. METHODS: HRV and CRC were analyzed in 70 children who were prescribed ICS treatment due to recurrent obstructive bronchitis. They underwent three different electrocardiogram and respiratory signals recordings, during and after treatment period. After treatment completion, they were followed up during 6 months and classified attending to their current asthma status. RESULTS: Vagal activity, as measured from HRV, and CRC, were reduced after treatment in those children at lower risk of asthma, whereas it kept unchanged in those with a worse prognosis. CONCLUSION: Results suggest that HRV analysis could be useful for the continuous monitoring of ANS anomalies present in asthma, thus contributing to evaluate the evolution of the disease, which is especially challenging in young children. SIGNIFICANCE: Noninvasive ANS assessment using HRV analysis could be useful in the continuous monitoring of asthma in children

Nowcasting Solar Energetic Particle Events Using Principal Component Analysis

We perform a principal component analysis (PCA) on a set of six solar variables (i.e. width/size () and velocity () of a coronal mass ejection, logarithm of the solar flare (SF) magnitude (), SF longitude (), duration (), and rise time ()). We classify the solar energetic particle (SEP) event radiation impact (in terms of the National Oceanic and Atmospheric Administration scales) with respect to the characteristics of their parent solar events. We further attempt to infer the possible prediction of SEP events. In our analysis, we use 126 SEP events with complete solar information, from 1997 to 2013. Each SEP event is a vector in six dimensions (corresponding to the six solar variables used in this work). The PCA transforms the input vectors into a set of orthogonal components. By mapping the characteristics of the parent solar events, a new base defined by these components led to the classification of the SEP events. We furthermore applied logistic regression analysis with single, as well as multiple explanatory variables, in order to develop a new index () for the nowcasting (short-term forecasting) of SEP events. We tested several different schemes for and validated our findings with the implementation of categorical scores (probability of detection (POD) and false-alarm rate (FAR)). We present and interpret the obtained scores, and discuss the strengths and weaknesses of the different implementations. We show that holds prognosis potential for SEP events. The maximum POD achieved is 77.78% and the relative FAR is 40.96%

Catalogue of 55-80 MeV solar proton events extending through solar cycles 23 and 24

We present a new catalogue of solar energetic particle events near the Earth, covering solar cycle 23 and the majority of solar cycle 24 (1996-2016), based on the 55-80 MeV proton intensity data gathered by the Solar and Heliospheric Observatory/the Energetic and Relativistic Nuclei and Electron experiment (SOHO/ERNE). In addition to ERNE proton and heavy ion observations, data from the Advanced Composition Explorer/Electron, Proton and Alpha Monitor (ACE/EPAM) (near-relativistic electrons), SOHO/EPHIN (Electron Proton Helium Instrument) (relativistic electrons), SOHO/LASCO (Large Angle and Spectrometric Coronagraph) (coronal mass ejections, CMEs) and Geostationary Operational Environmental Satellite (GOES) soft X-ray experiments are also considered and the associations between the particle and CME/X-ray events deduced to obtain a better understanding of each event. A total of 176 solar energetic particle (SEP) events have been identified as having occurred during the time period of interest; their onset and solar release times have been estimated using both velocity dispersion analysis (VDA) and time-shifting analysis (TSA) for protons, as well as TSA for near-relativistic electrons. Additionally, a brief statistical analysis was performed on the VDA and TSA results, as well as the X-rays and CMEs associated with the proton/electron events, both to test the viability of the VDA and to investigate possible differences between the two solar cycles. We find, in confirmation of a number of previous studies, that VDA results for protons that yield an apparent path length of 1 AU < s less than or similar to 3 AU seem to be useful, but those outside this range are probably unreliable, as evidenced by the anticorrelation between apparent path length and release time estimated from the X-ray activity. It also appears that even the first-arriving energetic protons apparently undergo significant pitch angle scattering in the interplanetary medium, with the resulting apparent path length being on average about twice the length of the spiral magnetic field. The analysis indicates an increase in high-energy SEP events originating from the far-eastern solar hemisphere; for instance, such an event with a well-established associated GOES flare has so far occurred three times during cycle 24 but possibly not at all during cycle 23. The generally lower level of solar activity during cycle 24, as opposed to cycle 23, has probably caused a significant decrease in total ambient pressure in the interplanetary space, leading to a larger proportion of SEP-associated halo-type CMEs. Taken together, these observations point to a qualitative difference between the two solar cycles

Prediction of Solar Proton Event Fluence spectra from their Peak flux spectra

Solar Proton Events (SPEs) are of great importance and significance for the study of Space Weather and Heliophysics. These populations of protons are accelerated at high energies ranging from a few MeVs to hundreds of MeVs and can pose a significant hazard both to equipment on board spacecrafts as well as astronauts as they are ionizing radiation. The ongoing study of SPEs can help to understand their characteristics, relative underlying physical mechanisms, and help in the design of forecasting and nowcasting systems which provide warnings and predictions. In this work, we present a study on the relationships between the Peak Flux and Fluence spectra of SPEs. This study builds upon existing work and provides further insights into the characteristics and the relationships of SPE Peak flux and Fluence spectra. Moreover it is shown how these relationships can be quantified in a sound manner and exploited in a simple methodology with which the Fluence spectrum of an SPE can be well predicted from its given Peak spectrum across two orders of magnitude of proton energies, from 5 MeV to 200 MeV. Finally it is discussed how the methodology in this work can be easily applied to forecasting and nowcasting systems

A Genotype-First Approach for the Molecular and Clinical Characterization of Uncommon De Novo Microdeletion of 20q13.33

Background: Subtelomeric deletions of the long arm of chromosome 20 are rare, with only 11 described in the literature. Clinical features of individuals with these microdeletions include severe limb malformations, skeletal abnormalities, growth retardation, developmental and speech delay, mental retardation, seizures and mild, non-specific dysmorphic features. Methodology/Principal Findings: We characterized microdeletions at 20q13.33 in six individuals referred for genetic evaluation of developmental delay, mental retardation, and/or congenital anomalies. A comparison to previously reported cases of 20q13.33 microdeletion shows phenotypic overlap, with clinical features that include mental retardation, developmental delay, speech and language deficits, seizures, and behavior problems such as autistic spectrum disorder. There does not appear to be a clinically recognizable constellation of dysmorphic features among individuals with subtelomeric 20q microdeletions. Conclusions/Significance: Based on genotype-phenotype correlation among individuals in this and previous studies, we discuss several possible candidate genes for specific clinical features, including ARFGAP1, CHRNA4 and KCNQ2 and neurodevelopmental deficits. Deletion of this region may play an important role in cognitive development

Association between promoter -1607 polymorphism of MMP1 and Lumbar Disc Disease in Southern Chinese

<p>Abstract</p> <p>Background</p> <p>Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix of the intervertebral disc. A SNP for guanine insertion/deletion (G/D), the -1607 promoter polymorphism, of the <it>MMP1 </it>gene was found significantly affecting promoter activity and corresponding transcription level. Hence it is a good candidate for genetic studies in DDD.</p> <p>Methods</p> <p>Southern Chinese volunteers between 18 and 55 years were recruited from the population. DDD in the lumbar spine was defined by MRI using Schneiderman's classification. Genomic DNA was isolated from the leukocytes and genotyping was performed using the Sequenom^®platform. Association and Hardy-Weinberg equilibrium checking were assessed by Chi-square test and Mann-Whitney U test.</p> <p>Results</p> <p>Our results showed substantial evidence of association between -1607 promoter polymorphism of <it>MMP1 </it>and DDD in the Southern Chinese subjects. D allelic was significantly associated with DDD (p value = 0.027, odds ratio = 1.41 with 95% CI = 1.04–1.90) while Genotypic association on the presence of D allele was also significantly associated with DDD (p value = 0.046, odds ratio = 1.50 with 95% CI = 1.01–2.24). Further age stratification showed significant genotypic as well as allelic association in the group of over 40 years (genotypic: p value = 0.035, odds ratio = 1.617 with 95% CI = 1.033–2.529; allelic: p value = 0.033, odds ratio = 1.445 with 95% CI = 1.029–2.029). Disc bulge, annular tears and the Schmorl's nodes were not associated with the D allele.</p> <p>Conclusion</p> <p>We demonstrated that individuals with the presence of D allele for the -1607 promoter polymorphism of <it>MMP1 </it>are about 1.5 times more susceptible to develop DDD when compared with those having G allele only. Further association was identified in individuals over 40 years of age. Disc bulge, annular tear as well as Schmorl's nodes were not associated with this polymorphism.</p

Genetic susceptibility of intervertebral disc degeneration among young Finnish adults

<p>Abstract</p> <p>Background</p> <p>Disc degeneration (DD) is a common condition that progresses with aging. Although the events leading to DD are not well understood, a significant genetic influence has been found. This study was undertaken to assess the association between relevant candidate gene polymorphisms and moderate DD in a well-defined and characterized cohort of young adults. Focusing on young age can be valuable in determining genetic predisposition to DD.</p> <p>Methods</p> <p>We investigated the associations of existing candidate genes for DD among 538 young adults with a mean age of 19 belonging to the 1986 Northern Finland Birth Cohort. Nineteen single nucleotide polymorphisms (SNP) in 16 genes were genotyped. We evaluated lumbar DD using the modified Pfirrmann classification and a 1.5-T magnetic resonance scanner for imaging.</p> <p>Results</p> <p>Of the 538 individuals studied, 46% had no degeneration, while 54% had DD and 51% of these had moderate DD. The risk of DD was significantly higher in subjects with an allele G of <it>IL6 </it>SNPs rs1800795 (OR 1.45, 95% CI 1.07-1.96) and rs1800797 (OR 1.37, 95% CI 1.02-1.85) in the additive inheritance model. The role of <it>IL6 </it>was further supported by the haplotype analysis, which resulted in an association between the GGG haplotype (SNPs rs1800797, rs1800796 and rs1800795) and DD with an OR of 1.51 (95% CI 1.11-2.04). In addition, we observed an association between DD and two other polymorphisms, <it>SKT </it>rs16924573 (OR 0.27 95% CI 0.07-0.96) and <it>CILP </it>rs2073711 in women (OR 2.04, 95% CI 1.07-3.89).</p> <p>Conclusion</p> <p>Our results indicate that <it>IL6</it>, <it>SKT </it>and <it>CILP </it>are involved in the etiology of DD among young adults.</p

Simulated-Physiological Loading Conditions Preserve Biological and Mechanical Properties of Caprine Lumbar Intervertebral Discs in Ex Vivo Culture

Low-back pain (LBP) is a common medical complaint and associated with high societal costs. Degeneration of the intervertebral disc (IVD) is assumed to be an important causal factor of LBP. IVDs are continuously mechanically loaded and both positive and negative effects have been attributed to different loading conditions